Compare Mirapex vs. Duopa

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Mirapex (Pramipexole)

Prescription only
Helps with movement problems.

Mirapex (Pramipexole) is an effective medicine for Parkinson's disease or restless leg syndrome, but there are potentially serious side effects.

Treats advanced stages of Parkinson's disease.

Duopa (carbidopa / levodopa) pumps carbidopa/levodopa into your body throughout the day. It is reserved for advanced Parkinson's disease when your symptoms become more frequent than the dosing of your tablets.

Upsides
  • In studies, Mirapex (Pramipexole) when taken by itself or with other medicines, was effective in lowering movement fluctuations for people with Parkinson's disease.
  • Mirapex (Pramipexole) is sometimes preferred over other medicines that treat Parkinson's disease in older people since it causes fewer movement and mental fluctuations.
  • Is effective for treating restless leg syndrome.
  • Available in a short-acting and a long-acting form.
  • Duopa (carbidopa / levodopa) allows you to have better control of your symptoms than oral tablets, especially in later stages of Parkinson's disease.
Downsides
  • Mirapex (Pramipexole) isn't a first-choice treatment for Parkinson's disease. It can be used by itself, but it's usually used with other medicines.
  • Mirapex (Pramipexole) can cause hallucinations in older people.
  • Not the best choice if you have kidney problems. Your doctor may have to adjust your dose based on your kidney function.
  • You can't suddenly stop taking Mirapex (Pramipexole). You'll have to slowly lower your dose, especially if you've been using it for a long time.
  • Given via pump so you'll need to have a procedure to attach the pump to your body.
  • You'll need to take good care of the pump so that it doesn't get disconnected or infected.
  • Duopa (carbidopa / levodopa) only lasts for 16 hours. You may need to take an extra dose of carbidopa/levodopa as tablet for nighttime control.
  • You need to keep Duopa (carbidopa / levodopa) in a fridge, but it should sit at room temperature 20 minutes before infusion.
Used for
Dosage forms
  • Pill
  • Extended release
  • Liquid
Price
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Reviews
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Side effects
45possible side effects
  • Postural hypotension
    53%
  • Dyskinesia
    47%
  • Extrapyramidal syndrome
    28%
  • Insomnia
    27%
  • Dizziness
    26%
  • Accidental injury
    17%
  • Hallucinations
    17%
  • Any side effect
    12%
  • Dream abnormalities
    11%
  • Nausea
    11%
  • Asthenia
    10%
  • Constipation
    10%
  • Confusion
    10%
  • Somnolence
    9%
  • Hallucinations, including visual, auditory and mixed
    9%
  • Dystonia
    8%
  • Dry mouth
    7%
  • Gait abnormalities
    7%
  • Hypertonia
    7%
  • Headache
    7%
  • Amnesia
    6%
  • Urinary frequency
    6%
  • Anorexia
    5%
  • General edema
    4%
  • Dyspnea
    4%
  • Accommodation abnormalities
    4%
  • Urinary tract infection
    4%
  • Chest pain
    3%
  • Malaise
    3%
  • Arthritis
    3%
  • Akathisia
    3%
  • Thinking abnormalities
    3%
  • Rhinitis
    3%
  • Vision abnormalities
    3%
  • Dizziness (postural)
    3%
  • Back pain
    3%
  • Peripheral edema
    2%
  • Twitching
    2%
  • Bursitis
    2%
  • Paranoid reaction
    2%
  • Pneumonia
    2%
  • Skin disorders
    2%
  • Urinary incontinence
    2%
  • Salivary hypersecretion
    2%
  • Diarrhea
    2%
See more detailed side effects
26possible side effects
  • Problems with J-tube
    56%
  • Nausea
    30%
  • Constipation
    22%
  • Redness and swelling at the J-tube site
    19%
  • Difficulty controlling movements
    14%
  • Depression
    11%
  • Discharge at the J-tube site
    11%
  • Swelling in the arms and legs
    8%
  • High blood pressure
    8%
  • Flu and cold
    8%
  • Sore throat
    8%
  • Collapsed lung
    8%
  • Confusion
    8%
  • Anxiety
    8%
  • Dizziness
    8%
  • Hiatal hernia
    8%
  • Intestinal blockage
    5%
  • Sleep problems
    5%
  • Fever
    5%
  • Scar tissue
    5%
  • Rash
    5%
  • Urinary tract infection
    5%
  • Hallucinations
    5%
  • Psychotic disorder
    5%
  • Diarrhea
    5%
  • Indigestion
    5%
See more detailed side effects
Risks and risk factors
  • Impulse control problems
  • Driving impairment
    • Taking with alcohol
    • Taking other medicines that make you less alert
  • Low blood pressure
    • Taking blood pressure-lowering medicines
  • Worsening kidney function
    • Current kidney problems
  • Skin cancer
    • Parkinson's disease
  • Hallucinations
    • Age 65 years or older
See more detailed risks and warnings
  • Stomach problems
    • Surgery to place the J-tube
  • Falling asleep during the day
    • Taking other medicines for Parkinson's
  • High fever and confusion
    • Stopping Duopa (carbidopa / levodopa) suddenly
  • Changes in behavior
  • Lack of impulse control
    • Taking other medicines for Parkinson's disease
See more detailed risks and warnings