Compare Mirapex vs. Duopa

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Mirapex
(pramipexole)

Duopa
(carbidopa / levodopa)

Helps with movement problems. Mirapex (Pramipexole) is an effective medicine for Parkinson's disease or restless leg syndrome, but there are potentially serious side effects.Treats advanced stages of Parkinson's disease. Duopa (carbidopa / levodopa) pumps carbidopa/levodopa into your body throughout the day. It is reserved for advanced Parkinson's disease when your symptoms become more frequent than the dosing of your tablets.
Reviews & ratings
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Have you used Mirapex (pramipexole)?
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Have you used Duopa (carbidopa / levodopa)?
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Side effects
MirapexDuopa
  • Any side effect 1%
  • Hallucinations 3%
  • Dizziness 1%
  • Somnolence 2%
  • Nausea 2%
  • Insomnia 5%
  • Constipation 8%
  • Asthenia 2%
  • Postural hypotension 5%
More Mirapex side effects »
  • Problems with J-tube 56%
  • Nausea 30%
  • Constipation 22%
  • Redness and swelling at the J-tube site 19%
  • Difficulty controlling movements 14%
  • Depression 11%
  • Discharge at the J-tube site 11%
  • Swelling in the arms and legs 8%
  • High blood pressure 8%
  • Flu and cold 8%
More Duopa side effects »
How it works
MirapexDuopa
Mirapex (Pramipexole) is a dopamine agonist. It binds to receptors in the brain and helps improve movement in people with Parkinson's disease or restless leg syndrome.Duopa (carbidopa / levodopa) is a combination of carbidopa and levodopa. Carbidopa allows levodopa to enter the brain and relieve symptoms of Parkinson's disease.
Type of medication
MirapexDuopa
Prescription onlyPrescription only
Available as
MirapexDuopa
  • Pill
  • Extended release
  • Liquid
Used for
MirapexDuopa
Risk factors for serious side effects
MirapexDuopa
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • Taking blood pressure-lowering medicines
  • Current kidney problems
  • Parkinson's disease
Detailed Mirapex (pramipexole) risks & warnings »
  • Surgery to place the J-tube
  • Taking other medicines for Parkinson's
  • Stopping Duopa (carbidopa / levodopa) suddenly
  • Taking other medicines for Parkinson's disease
Detailed Duopa (carbidopa / levodopa) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Food
MirapexDuopa
  • Take Mirapex (Pramipexole) with food if it makes you feel nauseous.
No food related info.
Kidneys and liver
MirapexDuopa
  • Mirapex (Pramipexole) is processed by the kidney. If you have kidney problems, talk to your doctor because you may need a different dose.
  • Not the best choice if you have kidney problems. Your doctor may have to adjust your dose based on your kidney function.
No kidneys and liver related info.
Pain
MirapexDuopa
No pain related info.
  • Call your doctor right away if you start having stomach pains around where the pump is connected.
Sleep
MirapexDuopa
No sleep related info.
  • Duopa (carbidopa / levodopa) can make you very sleepy. Don't drive or do anything that requires your full concentration until you know how Duopa (carbidopa / levodopa) affects you. You're more at risk if you're taking other medicines for Parkinson's. Talk to your doctor if this bothers you.
  • Duopa (carbidopa / levodopa) can make you very sleepy. Don't drive or do anything requiring concentration until you know how it affects you.
Upsides and benefits
MirapexDuopa
  • In studies, Mirapex (Pramipexole) when taken by itself or with other medicines, was effective in lowering movement fluctuations for people with Parkinson's disease.
  • Mirapex (Pramipexole) is sometimes preferred over other medicines that treat Parkinson's disease in older people since it causes fewer movement and mental fluctuations.
  • Is effective for treating restless leg syndrome.
  • Available in a short-acting and a long-acting form.
  • Duopa (carbidopa / levodopa) allows you to have better control of your symptoms than oral tablets, especially in later stages of Parkinson's disease.
Downsides and risks
MirapexDuopa
  • Mirapex (Pramipexole) isn't a first-choice treatment for Parkinson's disease. It can be used by itself, but it's usually used with other medicines.
  • Mirapex (Pramipexole) can cause hallucinations in older people.
  • Not the best choice if you have kidney problems. Your doctor may have to adjust your dose based on your kidney function.
  • You can't suddenly stop taking Mirapex (Pramipexole). You'll have to slowly lower your dose, especially if you've been using it for a long time.
  • Given via pump so you'll need to have a procedure to attach the pump to your body.
  • You'll need to take good care of the pump so that it doesn't get disconnected or infected.
  • Duopa (carbidopa / levodopa) only lasts for 16 hours. You may need to take an extra dose of carbidopa/levodopa as tablet for nighttime control.
  • You need to keep Duopa (carbidopa / levodopa) in a fridge, but it should sit at room temperature 20 minutes before infusion.
Tips from our pharmacists for people taking the medication
MirapexDuopa
  • You should start Mirapex (Pramipexole) at a low dose and your doctor will raise the dose slowly. This will help lower your risk of side effects, such as drowsiness and low blood pressure.
  • Can cause intense urges and compulsive behaviors that are hard to control, such as binge eating, gambling, and sexual urges. Talk to your doctor right away if you have any of these feelings.
  • You can suddenly fall asleep without warning while on this medicine. Don't perform any tasks that require mental alertness, like driving, or drinking alcohol until you know how Mirapex (Pramipexole) affects you. Let your doctor know if you have a history of sleep problems.
  • Take Mirapex (Pramipexole) 2 to 3 hours before bedtime for restless leg syndrome.
  • Take Mirapex (Pramipexole) with food if it makes you feel nauseous.
  • Duopa (carbidopa / levodopa) is given via pump. You need to have a minor procedure to connect the pump to your body.
  • You may still need to take carbidopa/levodopa in tablet form at night or if the pump disconnects.
  • Call your doctor right away if you start having stomach pains around where the pump is connected.
  • Duopa (carbidopa / levodopa) is only good for 16 hours. Throw out the cassette when the infusion is done even if there's still medicine left inside.
  • Duopa (carbidopa / levodopa) can make you very sleepy. Don't drive or do anything requiring concentration until you know how it affects you.
  • Don't stop taking Duopa (carbidopa / levodopa) suddenly. It can be very dangerous. Talk to your doctor if you want to stop taking Duopa (carbidopa / levodopa).
Learn more
More about MirapexSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Mirapex (pramipexole)?
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More about DuopaSide effectsAlternativesFDA package insert
Have you used Duopa (carbidopa / levodopa)?
Worth itNot sureNot worth it