Compare Mirapex vs. Rytary

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Mirapex
(Pramipexole)

Rytary
(carbidopa / levodopa)

Helps with movement problems. Mirapex (Pramipexole) is an effective medicine for Parkinson's disease or restless leg syndrome, but there are potentially serious side effects.Treats Parkinson's disease. Rytary (carbidopa / levodopa) can be used to treat Parkinson's disease, but it can be expensive.
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Reviews & ratings
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Have you used Mirapex (Pramipexole)?
Worth itNot sureNot worth it

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Have you used Rytary (carbidopa / levodopa)?
Worth itNot sureNot worth it
Side effects
MirapexRytary
  • Nausea 14%
  • Flu 3%
  • Nasal congestion 2%
  • Pain in extremity 2%
  • Any side effect 1%
  • Hallucinations 3%
  • Dizziness 1%
  • Drowsiness 2%
More Mirapex side effects »
  • Nausea 5%
  • Dizziness 4%
  • Dry mouth 2%
  • Abnormal dreams 2%
  • Difficulty controlling movements 2%
  • Anxiety 2%
  • Constipation 1%
More Rytary side effects »
How it works
MirapexRytary
Mirapex (Pramipexole) is a dopamine agonist. It binds to receptors in the brain and helps improve movement in people with Parkinson's disease or restless leg syndrome.Rytary (carbidopa / levodopa) is a combination of carbidopa and levodopa. Levodopa enters the brain and relieves the symptoms of Parkinson's disease. Carbidopa prevents levodopa from being broken down before it can enter the brain.
Type of medication
MirapexRytary
Prescription only
Prescription only
Available as
MirapexRytary
  • Pill
  • Extended release
  • Extended release capsule
Used for
MirapexRytary
Risk factors for serious side effects
MirapexRytary
    • Taking with alcohol
    • Taking other medicines that make you less alert
    • Taking blood pressure-lowering medicines
    • Current kidney problems
    • Parkinson's disease
    • Age 65 years or older
    Detailed Mirapex (Pramipexole) risks & warnings »
    • Taking other medicines for Parkinson's disease
    • Stopping Rytary (carbidopa / levodopa) suddenly
      • Taking other medicines for Parkinson's disease
      • History of heart attack
      • High risk for heart attack
      Detailed Rytary (carbidopa / levodopa) risks & warnings »
      Pregnancy

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Food
      MirapexRytary
      • Take Mirapex (Pramipexole) with food if it makes you feel nauseous.
      No food related info.
      Kidneys and liver
      MirapexRytary
      • Not the best choice if you have kidney problems. Your doctor may have to adjust your dose based on your kidney function.
      • Mirapex (Pramipexole) is processed by the kidney. If you have kidney problems, talk to your doctor because you may need a different dose.
      No kidneys and liver related info.
      Sleep
      MirapexRytary
      No sleep related info.
      • Rytary (carbidopa / levodopa) can make you sleepy or fall asleep suddenly without warning. Don't drive or do anything that requires concentration until you know how Rytary (carbidopa / levodopa) affects you. You're more at risk if you're taking other medicines for Parkinson's disease. Talk to your doctor if this bothers you.
      Upsides and benefits
      MirapexRytary
      • In studies, Mirapex (Pramipexole) when taken by itself or with other medicines, was effective in lowering movement fluctuations for people with Parkinson's disease.
      • Mirapex (Pramipexole) is sometimes preferred over other medicines that treat Parkinson's disease in older people since it causes fewer movement and mental fluctuations.
      • Is effective for treating restless leg syndrome.
      • Available in a short-acting and a long-acting form.
      • Rytary (carbidopa / levodopa) comes in 4 different strengths.
      • If you have private prescription insurance, there are programs to make Rytary (carbidopa / levodopa) more affordable.
      Downsides and risks
      MirapexRytary
      • Mirapex (Pramipexole) isn't a first-choice treatment for Parkinson's disease. It can be used by itself, but it's usually used with other medicines.
      • Mirapex (Pramipexole) can cause hallucinations in older people.
      • Not the best choice if you have kidney problems. Your doctor may have to adjust your dose based on your kidney function.
      • You can't suddenly stop taking Mirapex (Pramipexole). You'll have to slowly lower your dose, especially if you've been using it for a long time.
      • There are other forms of Rytary (carbidopa / levodopa) that are generic and much cheaper.
      • Your doctor might have to change the dose of Rytary (carbidopa / levodopa) often before they find a dose that works for you.
      • Rytary (carbidopa / levodopa) can cause uncontrollable movements to happen, but this doesn't happen for 3 to 5 years.
      • Rytary (carbidopa / levodopa) is not a cure for Parkinson's disease; it can only slow the disease down.
      Tips from our pharmacists for people taking the medication
      MirapexRytary
      • You should start Mirapex (Pramipexole) at a low dose and your doctor will raise the dose slowly. This will help lower your risk of side effects, such as drowsiness and low blood pressure.
      • Can cause intense urges and compulsive behaviors that are hard to control, such as binge eating, gambling, and sexual urges. Talk to your doctor right away if you have any of these feelings.
      • You can suddenly fall asleep without warning while on this medicine. Don't perform any tasks that require mental alertness, like driving, or drinking alcohol until you know how Mirapex (Pramipexole) affects you. Let your doctor know if you have a history of sleep problems.
      • Take Mirapex (Pramipexole) 2 to 3 hours before bedtime for restless leg syndrome.
      • Take Mirapex (Pramipexole) with food if it makes you feel nauseous.
      • If you can't swallow the capsules whole, they can be sprinkled on 1 to 2 tablespoons of applesauce. You have to take it right away.
      • Don't drive or do anything requiring concentration until you know how Rytary (carbidopa / levodopa) affects you.
      • You can't switch off other forms of carbidopa/levodopa to Rytary (carbidopa / levodopa) without talking to your doctor or pharmacist. They'll tell you how to do it safely.
      Learn more
      More about MirapexSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Mirapex (Pramipexole)?
      Worth itNot sureNot worth it
      More about RytarySide effectsAlternativesFDA package insert
      Have you used Rytary (carbidopa / levodopa)?
      Worth itNot sureNot worth it