Compare Mirapex vs. tolcapone

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Mirapex (Pramipexole)

Prescription only

Tasmar (tolcapone)

Prescription only
Helps with movement problems.

Mirapex (Pramipexole) is an effective medicine for Parkinson's disease or restless leg syndrome, but there are potentially serious side effects.

Treats Parkinson's disease.

Taking Tasmar (tolcapone) is the next step to control Parkinson's disease when carbidopa/levodopa don't work as well, however you might be more likely to have liver damage.

  • In studies, Mirapex (Pramipexole) when taken by itself or with other medicines, was effective in lowering movement fluctuations for people with Parkinson's disease.
  • Mirapex (Pramipexole) is sometimes preferred over other medicines that treat Parkinson's disease in older people since it causes fewer movement and mental fluctuations.
  • Is effective for treating restless leg syndrome.
  • Available in a short-acting and a long-acting form.
  • Tasmar (tolcapone) is part of the medicines used as the most common next step to control Parkinson's disease when carbidopa/levodopa doesn't work as well.
  • Tasmar (tolcapone) is available as a generic.
  • Tasmar (tolcapone) can be taken with or without food.
  • Mirapex (Pramipexole) isn't a first-choice treatment for Parkinson's disease. It can be used by itself, but it's usually used with other medicines.
  • Mirapex (Pramipexole) can cause hallucinations in older people.
  • Not the best choice if you have kidney problems. Your doctor may have to adjust your dose based on your kidney function.
  • You can't suddenly stop taking Mirapex (Pramipexole). You'll have to slowly lower your dose, especially if you've been using it for a long time.
  • When you first start taking Tasmar (tolcapone), your doctor might have to change the dose a lot because of all the side effects.
  • Tasmar (tolcapone) will only slow the disease down; it is not a cure for Parkinson's disease.
  • Unlike Comtan, Tasmar (tolcapone) is more likely to damage your liver, so you might need regular blood tests for the first few months.
  • Tasmar (tolcapone) is not available as a combination pill with carbidopa/levodopa, unlike Comtan.
  • Tasmar (tolcapone) can cause dry mouth and changes in blood pressure. Changes in blood pressure can make you feel faint and more likely to fall.
Used for
Dosage forms
  • Pill
  • Extended release
  • Pill
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Side effects
8possible side effects
  • Postural hypotension
  • Dyskinesia
  • Extrapyramidal syndrome
  • Insomnia
  • Dizziness
  • Accidental injury
  • Hallucinations
  • Any side effect
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10possible side effects
  • Difficulty controlling movement
  • Nausea
  • Sleeping problems
  • Excessive dreaming
  • Muscle cramps
  • Loss of appetite
  • Sleepiness
  • Uncontrolled muscle spasms
  • Lightheadedness from standing
  • Diarrhea
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Risks and warnings
  • Driving impairment

    Taking with alcohol

    ...and 1 more risk factors

  • Low blood pressure

    Taking blood pressure-lowering medicines

  • Worsening kidney function

    Current kidney problems

  • Skin cancer

    Parkinson's disease

  • Hallucinations

    Age 65 years or older

See more detailed risks and warnings
  • Liver damage

    Liver damage

  • Falling asleep during the day

    Taking other medicines for Parkinson's disease

  • Abnormal thinking and mood changes

    Taking antipsychotic medicines

  • Lack of impulse control

    Taking other medicines for Parkinson's disease

See more detailed risks and warnings