Compare Morphine Sulfate vs. Norco

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Ms Contin (Morphine Sulfate)

Prescription only
Treats severe pain.

Ms Contin (Morphine Sulfate) provides good long-term pain control without the need to take medicine frequently, but watch out for constipation.

4.8/ 7 average rating with 541 reviewsforMorphine Sulfate
Treats moderate to moderately severe pain.

Norco (hydrocodone / acetaminophen) is a good option to treat pain when over-the-counter medicines haven't worked, but it can lead to dependence and tolerance if taken for a long time.

5.0/ 7 average rating with 1194 reviewsforNorco
Upsides
  • Provides longer relieve for moderate to severe pain to improve quality of life.
  • Good for chronic pain that requires around-the-clock relief.
  • Might have fewer side effects than other opioid pain relievers.
  • Norco (hydrocodone / acetaminophen) has two medicines to treat moderate to moderately severe pain. The combination is more effective than either drug alone.
  • Norco (hydrocodone / acetaminophen) is more potent than many over-the-counter options.
  • You can take this with or without food.
  • This medicine also comes as a liquid if you have trouble swallowing.
  • Norco (hydrocodone / acetaminophen) is available as a generic.
Downsides
  • Doesn't work for as-needed or quick pain relief.
  • Dizziness and drowsiness is common, but your body may adjust.
  • Everyone will get constipation - always stay hydrated and take stool softener or stimulant on days you're taking Ms Contin (Morphine Sulfate) if you need.
  • Long term use will likely cause physical dependence.
  • Must be weaned slowly off the medicine after use longer than 2 weeks.
  • Constipation, dizziness, drowsiness, and nausea can commonly occur.
  • Since Norco (hydrocodone / acetaminophen) is a controlled medication, it cannot be refilled or transferred to another pharmacy.
  • Long-term use can cause dependence and tolerance.
  • Too much Norco (hydrocodone / acetaminophen) can damage the liver.
  • Not effective in treating all kinds of pain.
Used for
Dosage forms
  • Pill
  • Extended release
  • Oral solution
  • Liquid
  • Suppository
  • Pill
  • Liquid
Price
Lowest price near you
$201.89
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Lowest price near you
$196.12
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Reviews
541 
55%
think this treatment is worth it
43%
think this treatment works well
20%
think this treatment is a hassle

Have you used Ms Contin (Morphine Sulfate)?

Leave a review
1194 
67%
think this treatment is worth it
44%
think this treatment works well
13%
think this treatment is a hassle

Have you used Norco (hydrocodone / acetaminophen)?

Leave a review
Side effects
The Ms Contin (Morphine Sulfate) FDA package insert doesn’t have numbers about how common side effects are.
The Norco (hydrocodone / acetaminophen) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Death from lack of oxygen to the body (respiratory depression)

    Current use of medicine that affects liver enzyme CYP 3A4

    ...and 4 more risk factors

  • Death from overdose

    Children age 18 and younger

  • Death in newborn babies from opioid withdrawal (Neonatal opioid withdrawal syndrome)

    Long-term use during pregnancy

  • Tolerance, dependence, and addiction

    Taking more than the prescribed dose

    ...and 2 more risk factors

  • Driving impairment

    Taking with alcohol

    ...and 2 more risk factors

  • Low blood pressure

    Age 65 years or older

See more detailed risks and warnings
  • Liver failure

    Current liver disease

    ...and 2 more risk factors

  • Slowed breathing

    Age 65 or greater

    ...and 3 more risk factors

  • Severe allergic reactions

    Taking more than the prescribed dose

    ...and 3 more risk factors

  • Tolerance, dependence, and addiction

    Taking more than the prescribed dose

    ...and 3 more risk factors

  • Constipation

    Age 65 or greater

    ...and 2 more risk factors

  • Confusion and drowsiness

    Drinking alcohol

    ...and 1 more risk factors

See more detailed risks and warnings