Compare Morphine Sulfate vs. Oxycodone

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Ms Contin
(Morphine Sulfate)

Oxycontin
(Oxycodone)

Treats severe pain. Ms Contin (Morphine Sulfate) provides good long-term pain control without the need to take medicine frequently, but watch out for constipation.Treats severe pain. Oxycontin (Oxycodone) provides options for treating both short and long-term moderate to severe pain, but no matter how long you take it, you’ll need to watch out for constipation.
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Reviews & ratings
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4.7781954887218046Morphine Sulfate
Reviews for Ms Contin (Morphine Sulfate)
55%
of people (All ages) say Ms Contin (Morphine Sulfate) is worth it
43%
say it works well
20%
say it's a big hassle
532 reviews
Have you used Ms Contin (Morphine Sulfate)?
Worth itNot sureNot worth it
Reviews for Oxycontin (Oxycodone)
66%
+11% vs. Ms Contin (Morphine Sulfate)
50%
+7% vs. Ms Contin (Morphine Sulfate)
19%
+1% vs. Ms Contin (Morphine Sulfate)
1229 reviews
Have you used Oxycontin (Oxycodone)?
Worth itNot sureNot worth it
Side effects
Morphine SulfateOxycodone

The Morphine Sulfate FDA package insert doesn’t have numbers about how common side effects are.

More about Morphine Sulfate side effects »
  • Drowsiness 19%
  • Constipation 16%
  • Nausea 12%
  • Itching 11%
  • Vomiting 5%
  • Dizziness 4%
  • Dry mouth 4%
  • Sweating 3%
More Oxycodone side effects »
How it works
Morphine SulfateOxycodone
Ms Contin (Morphine Sulfate) is an opioid medicine that works in the brain to lower pain perception.Oxycontin (Oxycodone) is an opioid medicine (similar to morphine) that works in the brain to lower pain perception.
Type of medication
Morphine SulfateOxycodone
Pain reliever
Opioid
Prescription only
Pain reliever
Opioid
Prescription only
Available as
Morphine SulfateOxycodone
  • Pill
  • Extended release
  • Oral solution
  • Liquid
  • Suppository
  • Pill
  • Extended release
  • Oral solution
  • Liquid
Used for (click to learn more)
Morphine SulfateOxycodone
Risk factors for serious side effects
Morphine SulfateOxycodone
  • Current use of medicine that affects liver enzyme CYP 3A4
  • Age 65 or greater
  • Higher dose
  • People with not enough thyroid hormones
  • History of lung problems
  • Children age 18 and younger
  • Long-term use during pregnancy
  • Taking more than the prescribed dose
  • Long-term use
  • History of drug abuse
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • Age 65 or greater
  • Age 65 years or older
Detailed Ms Contin (Morphine Sulfate) risks & warnings »
  • Current use of medicine that affects liver enzyme CYP 3A4
  • Age 65 or greater
  • Higher dose
  • People with not enough thyroid hormones
  • History of lung problems
  • Children age 18 and younger
  • Long-term use during pregnancy
  • Taking more than the prescribed dose
  • Long-term use
  • History of drug abuse
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • Age 65 or greater
  • Age 65 years or older
      Detailed Oxycontin (Oxycodone) risks & warnings »
      Pregnancy

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

      Alcohol
      Morphine SulfateOxycodone
      No alcohol related info.
      • Dizziness and drowsiness is common. While taking this, it’s best to avoid alcohol.
      Food
      Morphine SulfateOxycodone
      • Take it with food to lower the chance of an upset stomach.
      • Take it with food to lower the chance of an upset stomach.
      Pain
      Morphine SulfateOxycodone
      • Good for chronic pain that requires around-the-clock relief.
      • Doesn't work for as-needed or quick pain relief.
      • Oxycontin (Oxycodone) immediate-release (short acting) works best for “as needed” or “break-through” pain.
      • Long-acting tablets are good for chronic pain that requires around-the-clock relief.
      Sleep
      Morphine SulfateOxycodone
      • Dizziness and drowsiness is common, but your body may adjust.
      • Dizziness and drowsiness is common. While taking this, it’s best to avoid alcohol.
      Upsides and benefits
      Morphine SulfateOxycodone
      • Provides longer relieve for moderate to severe pain to improve quality of life.
      • Good for chronic pain that requires around-the-clock relief.
      • Might have fewer side effects than other opioid pain relievers.
      • Oxycontin (Oxycodone) immediate-release (short acting) works best for “as needed” or “break-through” pain.
      • Long-acting tablets are good for chronic pain that requires around-the-clock relief.
      • Can have fewer side effects than other opioid pain relievers.
      • Generally considered to be stronger than morphine.
      Downsides and risks
      Morphine SulfateOxycodone
      • Doesn't work for as-needed or quick pain relief.
      • Dizziness and drowsiness is common, but your body may adjust.
      • Everyone will get constipation - always stay hydrated and take stool softener or stimulant on days you're taking Ms Contin (Morphine Sulfate) if you need.
      • Long term use will likely cause physical dependence.
      • Must be weaned slowly off the medicine after use longer than 2 weeks.
      • Dizziness and drowsiness is common. While taking this, it’s best to avoid alcohol.
      • You’ll need to take the immediate-release for a few weeks before you can be switched to the long-acting formulation. It’s not safe to start taking the long-acting one if you've never taken an opioid pain medicine before.
      • Everyone will get constipation, so it’s best to stay hydrated and take a stool softener while on Oxycontin (Oxycodone).
      • Long-term use will likely cause physical dependence.
      • Need be weaned slowly off the medicine after using it longer than two weeks.
      Tips from our pharmacists for people taking the medication
      Morphine SulfateOxycodone
      • Opioid pain medicine that provides longer pain relief—up to 12 hours.
      • Works best when taken regularly instead of as-needed.
      • Especially useful for people with chronic pain problems.
      • May not be the best choice for people who have never taken an opioid pain medicine because it lasts so long.
      • Swallow it whole. Don't crush, chew, or split the medicine.
      • Can make you dizzy or drowsy.
      • Avoid activities that need you to be fully alert until you know how it affects you.
      • Take it with food to lower the chance of an upset stomach.
      • Constipation is common and may not go away while you're taking this medicine. Drinking lots of water and taking laxatives can help.
      • Talk to your doctor if it doesn't help enough for your pain, or if the side effects are really bad.
      • Opioid pain medicine that provides longer pain relief—up to 12 hours.
      • Works best when taken regularly instead of as-needed.
      • Especially useful for people with chronic pain problems.
      • May not be the best choice for people who have never taken an opioid pain medicine because it lasts so long.
      • Swallow it whole. Don't crush, chew, or split the medicine.
      • Can make you dizzy or drowsy.
      • Avoid activities that need you to be fully alert until you know how it affects you.
      • Take it with food to lower the chance of an upset stomach.
      • Constipation is common and may not go away while you're taking this medicine. Drinking lots of water and taking laxatives can help.
      • Talk to your doctor if it doesn't help enough for your pain, or if the side effects are really bad.
      Learn more
      More about Morphine SulfateSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Ms Contin (Morphine Sulfate)?
      Worth itNot sureNot worth it
      More about OxycodoneSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Oxycontin (Oxycodone)?
      Worth itNot sureNot worth it