Compare Morphine Sulfate vs. Oxycodone

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Ms Contin (Morphine Sulfate)

Prescription only

Oxycontin (Oxycodone)

Prescription only
Treats severe pain.

Ms Contin (Morphine Sulfate) provides good long-term pain control without the need to take medicine frequently, but watch out for constipation.

4.8/ 7 average rating with 541 reviewsforMorphine Sulfate
Treats severe pain.

Oxycontin (Oxycodone) provides options for treating both short and long-term moderate to severe pain, but no matter how long you take it, you’ll need to watch out for constipation.

5.2/ 7 average rating with 1241 reviewsforOxycodone
Upsides
  • Provides longer relieve for moderate to severe pain to improve quality of life.
  • Good for chronic pain that requires around-the-clock relief.
  • Might have fewer side effects than other opioid pain relievers.
  • Oxycontin (Oxycodone) immediate-release (short acting) works best for “as needed” or “break-through” pain.
  • Long-acting tablets are good for chronic pain that requires around-the-clock relief.
  • Can have fewer side effects than other opioid pain relievers.
  • Generally considered to be stronger than morphine.
Downsides
  • Doesn't work for as-needed or quick pain relief.
  • Dizziness and drowsiness is common, but your body may adjust.
  • Everyone will get constipation - always stay hydrated and take stool softener or stimulant on days you're taking Ms Contin (Morphine Sulfate) if you need.
  • Long term use will likely cause physical dependence.
  • Must be weaned slowly off the medicine after use longer than 2 weeks.
  • Dizziness and drowsiness is common. While taking this, it’s best to avoid alcohol.
  • You’ll need to take the immediate-release for a few weeks before you can be switched to the long-acting formulation. It’s not safe to start taking the long-acting one if you've never taken an opioid pain medicine before.
  • Everyone will get constipation, so it’s best to stay hydrated and take a stool softener while on Oxycontin (Oxycodone).
  • Long-term use will likely cause physical dependence.
  • Need be weaned slowly off the medicine after using it longer than two weeks.
Used for
Dosage forms
  • Pill
  • Extended release
  • Oral solution
  • Liquid
  • Suppository
  • Pill
  • Extended release
  • Oral solution
  • Liquid
Price
Lowest price near you
$201.89
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Lowest price near you
$18.58
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Reviews
541 
55%
think this treatment is worth it
43%
think this treatment works well
20%
think this treatment is a hassle

Have you used Ms Contin (Morphine Sulfate)?

Leave a review
1241 
66%
think this treatment is worth it
50%
think this treatment works well
19%
think this treatment is a hassle

Have you used Oxycontin (Oxycodone)?

Leave a review
Side effects
The Ms Contin (Morphine Sulfate) FDA package insert doesn’t have numbers about how common side effects are.
10possible side effects
  • Abdominal pain
    5%
  • Diarrhea
    5%
  • Dyspepsia
    5%
  • Gastritis
    5%
  • Chills
    5%
  • Fever
    5%
  • Anorexia
    5%
  • Twitching
    5%
  • Abnormal dreams
    5%
  • Anxiety
    5%
See more detailed side effects
Risks and warnings
  • Death from lack of oxygen to the body (respiratory depression)

    Current use of medicine that affects liver enzyme CYP 3A4

    ...and 4 more risk factors

  • Death from overdose

    Children age 18 and younger

  • Death in newborn babies from opioid withdrawal (Neonatal opioid withdrawal syndrome)

    Long-term use during pregnancy

  • Tolerance, dependence, and addiction

    Taking more than the prescribed dose

    ...and 2 more risk factors

  • Driving impairment

    Taking with alcohol

    ...and 2 more risk factors

  • Low blood pressure

    Age 65 years or older

See more detailed risks and warnings
  • Death from lack of oxygen to the body (respiratory depression)

    Current use of medicine that affects liver enzyme CYP 3A4

    ...and 4 more risk factors

  • Death from overdose

    Children age 18 and younger

  • Death in newborn babies from opioid withdrawal (Neonatal opioid withdrawal syndrome)

    Long-term use during pregnancy

  • Tolerance, dependence, and addiction

    Taking more than the prescribed dose

    ...and 2 more risk factors

  • Driving impairment

    Taking with alcohol

    ...and 2 more risk factors

  • Low blood pressure

    Age 65 years or older

See more detailed risks and warnings