Compare Morphine Sulfate vs. tramadol

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Ms Contin (Morphine Sulfate)

Prescription only

Ultram (tramadol)

Prescription only
Treats severe pain.

Ms Contin (Morphine Sulfate) provides good long-term pain control without the need to take medicine frequently, but watch out for constipation.

4.8/ 7 average rating with 541 reviewsforMorphine Sulfate
Treats moderate to severe pain.

Ultram (tramadol) works well for pain. Although it's a little weaker than other opioids, it can still be addictive.

4.6/ 7 average rating with 642 reviewsfortramadol
Upsides
  • Provides longer relieve for moderate to severe pain to improve quality of life.
  • Good for chronic pain that requires around-the-clock relief.
  • Might have fewer side effects than other opioid pain relievers.
  • Relieves moderate to severe pain. It has been shown to work as well as other opioid pain medications.
  • Compared to typical opioids, it provides unique pain relief and effects on your mood when taken regularly.
  • Has a lower chance of causing breathing problems compared to other typical opioids.
  • Doesn't cause as much constipation as other opioid pain medicines. Staying hydrated and taking laxatives can help treat this side effect.
Downsides
  • Doesn't work for as-needed or quick pain relief.
  • Dizziness and drowsiness is common, but your body may adjust.
  • Everyone will get constipation - always stay hydrated and take stool softener or stimulant on days you're taking Ms Contin (Morphine Sulfate) if you need.
  • Long term use will likely cause physical dependence.
  • Must be weaned slowly off the medicine after use longer than 2 weeks.
  • Some people think it's weaker than other opioid pain medications. It can also cause more upset stomach.
  • Like other opioid pain relievers, Ultram (tramadol) has a high risk of addiction, abuse, misuse, overdose, and death.
  • The extended release version of Ultram (tramadol) should only be used for severe pain that requires daily, around-the-clock treatment once alternative treatments haven't worked.
  • It's a controlled substance regulated by the federal government. This means that your use of Ultram (tramadol) will be tracked to prevent potential prescription abuse.
  • Like all opioids, don't use when pregnant, since the baby can become dependent on it and have withdrawal symptoms after birth.
Used for
Dosage forms
  • Pill
  • Extended release
  • Oral solution
  • Liquid
  • Suppository
  • Pill
  • Extended release
  • Extended release capsule
  • Dissolving tablet
Price
Lowest price near you
$201.89
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$45.6
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Reviews
541 
55%
think this treatment is worth it
43%
think this treatment works well
20%
think this treatment is a hassle

Have you used Ms Contin (Morphine Sulfate)?

Leave a review
642 
61%
think this treatment is worth it
40%
think this treatment works well
16%
think this treatment is a hassle

Have you used Ultram (tramadol)?

Leave a review
Side effects
The Ms Contin (Morphine Sulfate) FDA package insert doesn’t have numbers about how common side effects are.
10possible side effects
  • Dizziness
    26%
  • Nausea
    24%
  • Constipation
    24%
  • Headache
    18%
  • Sleepiness
    16%
  • Vomiting
    9%
  • Pruritus
    8%
  • CNS Stimulation
    7%
  • Asthenia
    6%
  • Sweating
    6%
See more detailed side effects
Risks and warnings
  • Death from lack of oxygen to the body (respiratory depression)

    Current use of medicine that affects liver enzyme CYP 3A4

    ...and 4 more risk factors

  • Death from overdose

    Children age 18 and younger

  • Death in newborn babies from opioid withdrawal (Neonatal opioid withdrawal syndrome)

    Long-term use during pregnancy

  • Tolerance, dependence, and addiction

    Taking more than the prescribed dose

    ...and 2 more risk factors

  • Driving impairment

    Taking with alcohol

    ...and 2 more risk factors

  • Low blood pressure

    Age 65 years or older

See more detailed risks and warnings
  • Breathing problems

    Age 65 or greater

    ...and 2 more risk factors

  • Addiction, abuse, and overdose

    Taking more than the prescribed dose

    ...and 2 more risk factors

  • Withdrawal in newborns

    Pregnancy

  • Accidental ingestion

    Children can reach medication

See more detailed risks and warnings