Compare Mucinex D vs. Delsym

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Mucinex D (Guaifenesin / Pseudoephedrine)

Over-the-counter
Breaks up mucus and relieves congestion.

Mucinex D (Guaifenesin / Pseudoephedrine) is good if you have a stuffy nose and a cough with mucus, but it could keep you up at night.

5.2/ 7 average rating with 1249 reviewsforMucinex D
Relieves coughing.

Delsym (Dextromethorphan) is a good option for treating dry cough. It's not safe to take with MAO inhibitors though.

4.5/ 7 average rating with 127 reviewsforDelsym
Upsides
  • Mucinex D (Guaifenesin / Pseudoephedrine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have sinus and chest congestion.
  • Helps loosen the mucus in your airways so that you can cough it up more easily.
  • Works well to clear nasal congestion and help you breathe better.
  • Good for treating dry cough.
  • Available in drugstores either by itself or in combination with other medications to treat cold and allergy symptoms.
  • Available as a liquid and a tablet.
  • Some products relieve cough for up to 12 hours.
Downsides
  • Pseudoephedrine, the decongestant in Mucinex D (Guaifenesin / Pseudoephedrine), can make your heart race or make you feel anxious and restless.
  • Doesn't work as well if you use it for more than 4 days at a time.
  • Although you don't need a prescription to get Mucinex D (Guaifenesin / Pseudoephedrine), you need to show a photo ID to buy it in the drugstore.
  • Mucinex D (Guaifenesin / Pseudoephedrine) isn’t useful if you have a dry cough.
  • Can't take dextromethorphan if you're taking MAO inhibitors (drugs used to treat Parkinson's disease, depression, and other emotional conditions). If taken together, they will cause dangerously high blood pressure levels.
  • If you're taking this in combination with other cold and allergy medications, you should read labels closely to make sure you're not accidentally taking too much of a single ingredient.
Used for
Dosage forms
  • Extended release
  • Pill
  • Liquid extended release
No pricing information available
No pricing information available
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Reviews
1249 
76%
think this treatment is worth it
41%
think this treatment works well
7%
think this treatment is a hassle

Have you used Mucinex D (Guaifenesin / Pseudoephedrine)?

Leave a review
127 
63%
think this treatment is worth it
32%
think this treatment works well
12%
think this treatment is a hassle

Have you used Delsym (Dextromethorphan)?

Leave a review
Side effects
The Mucinex D (Guaifenesin / Pseudoephedrine) FDA package insert doesn’t have numbers about how common side effects are.
The Delsym (Dextromethorphan) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • High blood pressure

    History of high blood pressure

  • Heart problems

    History of heart problems

    ...and 1 more risk factors

See more detailed risks and warnings
  • Serotonin syndrome

    Using other medications that affect serotonin

See more detailed risks and warnings