Compare Mucinex D vs. Delsym

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Mucinex D
(guaifenesin / pseudoephedrine)

Delsym
(dextromethorphan)

Breaks up mucus and relieves congestion. Mucinex D (Guaifenesin / Pseudoephedrine) is good if you have a stuffy nose and a cough with mucus, but it could keep you up at night.Relieves coughing. Delsym (Dextromethorphan) is a good option for treating dry cough. It's not safe to take with MAO inhibitors though.
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Reviews & ratings
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5.16Mucinex D
Reviews for Mucinex D (guaifenesin / pseudoephedrine)
76%
of people (All ages) say Mucinex D (guaifenesin / pseudoephedrine) is worth it
41%
say it works well
7%
say it's a big hassle
1249 reviews
Have you used Mucinex D (guaifenesin / pseudoephedrine)?
Worth itNot sureNot worth it
Reviews for Delsym (dextromethorphan)
63%
-13% worse vs. Mucinex D (guaifenesin / pseudoephedrine)
32%
-9% worse vs. Mucinex D (guaifenesin / pseudoephedrine)
12%
-5% worse vs. Mucinex D (guaifenesin / pseudoephedrine)
127 reviews
Have you used Delsym (dextromethorphan)?
Worth itNot sureNot worth it
Side effects
Mucinex DDelsym

We haven’t found good data for Mucinex D side effects.

FDA side effect reports for Mucinex D »

We haven’t found good data for Delsym side effects.

FDA side effect reports for Delsym »
How it works
Mucinex DDelsym
Mucinex D (Guaifenesin / Pseudoephedrine) is a combination medicine. Guaifenesin (an expectorant) breaks up and thins out mucus. Pseudoephedrine (a decongestant) clears your sinuses.Delsym (Dextromethorphan) is a cough suppressant.
Type of medication
Mucinex DDelsym
Over-the-counter
Over-the-counter
Available as
Mucinex DDelsym
  • Extended release
  • Pill
  • Liquid extended release
Used for
Mucinex DDelsym
Risk factors for serious side effects
Mucinex DDelsym
  • History of high blood pressure
  • History of heart problems
  • Age 65 years or older
    Detailed Mucinex D (guaifenesin / pseudoephedrine) risks & warnings »
    • Using other medications that affect serotonin
    Detailed Delsym (dextromethorphan) risks & warnings »
    Pregnancy

    The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

    The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

    Upsides and benefits
    Mucinex DDelsym
    • Mucinex D (Guaifenesin / Pseudoephedrine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have sinus and chest congestion.
    • Helps loosen the mucus in your airways so that you can cough it up more easily.
    • Works well to clear nasal congestion and help you breathe better.
    • Good for treating dry cough.
    • Available in drugstores either by itself or in combination with other medications to treat cold and allergy symptoms.
    • Available as a liquid and a tablet.
    • Some products relieve cough for up to 12 hours.
    Downsides and risks
    Mucinex DDelsym
    • Pseudoephedrine, the decongestant in Mucinex D (Guaifenesin / Pseudoephedrine), can make your heart race or make you feel anxious and restless.
    • Doesn't work as well if you use it for more than 4 days at a time.
    • Although you don't need a prescription to get Mucinex D (Guaifenesin / Pseudoephedrine), you need to show a photo ID to buy it in the drugstore.
    • Mucinex D (Guaifenesin / Pseudoephedrine) isn’t useful if you have a dry cough.
    • Can't take dextromethorphan if you're taking MAO inhibitors (drugs used to treat Parkinson's disease, depression, and other emotional conditions). If taken together, they will cause dangerously high blood pressure levels.
    • If you're taking this in combination with other cold and allergy medications, you should read labels closely to make sure you're not accidentally taking too much of a single ingredient.
    Tips from our pharmacists for people taking the medication
    Mucinex DDelsym
    • Drink plenty of fluids while taking Mucinex D (Guaifenesin / Pseudoephedrine) because liquid helps break down mucus.
    • Follow age-specific dosing instructions on how much to take. Don't take more than the recommended dose.
    • You need to show an ID to buy Mucinex D (Guaifenesin / Pseudoephedrine) in the drugstore because it contains pseudoephedrine.
    • Don't take Mucinex D (Guaifenesin / Pseudoephedrine) too close to bedtime since it can keep you awake.
    • Can cause an irregular or fast heartbeat, and can raise your blood pressure.
    • Cough suppressant starts working in 15 to 30 minutes.
    • Follow age-specific dosing instructions on how much to take. Don't take more than the recommended dose.
    • If your cough lasts more than 7 days, call your doctor.
    Learn more
    More about Mucinex DSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Mucinex D (guaifenesin / pseudoephedrine)?
    Worth itNot sureNot worth it
    More about DelsymSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Delsym (dextromethorphan)?
    Worth itNot sureNot worth it