Compare Mucinex D vs. Robitussin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Mucinex D
(guaifenesin / pseudoephedrine)

Robitussin
(guaifenesin)

Breaks up mucus and relieves congestion. Mucinex D (Guaifenesin / Pseudoephedrine) is good if you have a stuffy nose and a cough with mucus, but it could keep you up at night.Breaks up mucus that causes cough. Robitussin (Guaifenesin) is a useful medicine for loosening congestion in your chest and throat, but it doesn't last as long as other guaifenesin products.
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Reviews & ratings
Filter group. All currently selected
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5.16Mucinex D
Reviews for Mucinex D (guaifenesin / pseudoephedrine)
76%
of people (All ages) say Mucinex D (guaifenesin / pseudoephedrine) is worth it
41%
say it works well
7%
say it's a big hassle
1249 reviews
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Side effects
Mucinex DRobitussin

We haven’t found good data for Mucinex D side effects.

FDA side effect reports for Mucinex D »

We haven’t found good data for Robitussin side effects.

FDA side effect reports for Robitussin »
How it works
Mucinex DRobitussin
Mucinex D (Guaifenesin / Pseudoephedrine) is a combination medicine. Guaifenesin (an expectorant) breaks up and thins out mucus. Pseudoephedrine (a decongestant) clears your sinuses.Robitussin (Guaifenesin) is an expectorant. It contains guaifenesin, which thins and loosens mucus, making it easier to cough out.
Type of medication
Mucinex DRobitussin
Over-the-counter
Over-the-counter
Available as
Mucinex DRobitussin
  • Extended release
  • Liquid
Used for
Mucinex DRobitussin
Risk factors for serious side effects
Mucinex DRobitussin
  • History of high blood pressure
  • History of heart problems
  • Age 65 years or older
    Detailed Mucinex D (guaifenesin / pseudoephedrine) risks & warnings »
      Detailed Robitussin (guaifenesin) risks & warnings »
      Pregnancy

      The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

      The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

      Upsides and benefits
      Mucinex DRobitussin
      • Mucinex D (Guaifenesin / Pseudoephedrine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have sinus and chest congestion.
      • Helps loosen the mucus in your airways so that you can cough it up more easily.
      • Works well to clear nasal congestion and help you breathe better.
      • Robitussin (Guaifenesin) reduces the thickness and amount of mucus in your throat and chest.
      • It’s available at the drugstore either by itself or in combination with other medications to treat cold and flu symptoms.
      • Available in multiple forms.
      • Can be used in children 12 years and older.
      Downsides and risks
      Mucinex DRobitussin
      • Pseudoephedrine, the decongestant in Mucinex D (Guaifenesin / Pseudoephedrine), can make your heart race or make you feel anxious and restless.
      • Doesn't work as well if you use it for more than 4 days at a time.
      • Although you don't need a prescription to get Mucinex D (Guaifenesin / Pseudoephedrine), you need to show a photo ID to buy it in the drugstore.
      • Mucinex D (Guaifenesin / Pseudoephedrine) isn’t useful if you have a dry cough.
      • Robitussin (Guaifenesin) doesn't last as long as other products that contain guaifenesin. Mucinex's extended release form lasts 12 hours and Robitussin (Guaifenesin)'s lasts 8 hours.
      • You need to drink a lot of fluids while taking this medication or it won't work as well.
      • Robitussin (Guaifenesin) isn’t useful if you have a dry cough.
      • Can cause nausea, headache, and an upset stomach.
      Tips from our pharmacists for people taking the medication
      Mucinex DRobitussin
      • Drink plenty of fluids while taking Mucinex D (Guaifenesin / Pseudoephedrine) because liquid helps break down mucus.
      • Follow age-specific dosing instructions on how much to take. Don't take more than the recommended dose.
      • You need to show an ID to buy Mucinex D (Guaifenesin / Pseudoephedrine) in the drugstore because it contains pseudoephedrine.
      • Don't take Mucinex D (Guaifenesin / Pseudoephedrine) too close to bedtime since it can keep you awake.
      • Can cause an irregular or fast heartbeat, and can raise your blood pressure.
      • Drink plenty of fluids while taking Robitussin (Guaifenesin) because liquid helps break down mucus.
      • Steam from a humidifier, cool mist vaporizer, or hot shower can also help add moisture to your airways.
      • Follow age-specific dosing instructions on how much to take.
      • If your cough lasts more than 7 days, call your doctor.
      • Robitussin (Guaifenesin) only works for coughs with mucus, so don't use it if you have a dry cough.
      Learn more
      More about Mucinex DSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Mucinex D (guaifenesin / pseudoephedrine)?
      Worth itNot sureNot worth it
      More about RobitussinSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Robitussin (guaifenesin)?
      Worth itNot sureNot worth it