Compare Mucinex D vs. Tylenol Cold Multi-Symptom Daytime

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Mucinex D
(Guaifenesin / Pseudoephedrine)

Tylenol Cold Multi-Symptom Daytime
(Acetaminophen / Dextromethorphan / Phenylephrine)

Breaks up mucus and relieves congestion. Mucinex D (Guaifenesin / Pseudoephedrine) is good if you have a stuffy nose and a cough with mucus, but it could keep you up at night.Relieves cold and flu symptoms. Tylenol Cold Multi-Symptom Daytime (Acetaminophen / Dextromethorphan / Phenylephrine) is good for multiple cold symptoms, but it's more medicine than you need if you only have one symptom.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
5.155573376102646Mucinex D
Reviews for Mucinex D (Guaifenesin / Pseudoephedrine)
76%
of people say Mucinex D (Guaifenesin / Pseudoephedrine) is worth it
41%
say it works well
7%
say it's a big hassle

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Side effects
Mucinex DTylenol Cold Multi-Symptom Daytime

We haven’t found good data for Mucinex D side effects.

FDA side effect reports for Mucinex D »

We haven’t found good data for Tylenol Cold Multi-Symptom Daytime side effects.

FDA side effect reports for Tylenol Cold Multi-Symptom Daytime »
How it works
Mucinex DTylenol Cold Multi-Symptom Daytime
Mucinex D (Guaifenesin / Pseudoephedrine) is a combination medicine. Guaifenesin (an expectorant) breaks up and thins out mucus. Pseudoephedrine (a decongestant) clears your sinuses.Tylenol Cold Multi-Symptom Daytime (Acetaminophen / Dextromethorphan / Phenylephrine) is a combination medicine that treats cold and flu symptoms. Acetaminophen relieves pain and reduces fever. Dextromethorphan is a cough suppressant. Phenylephrine is a decongestant that clears your sinuses.
Type of medication
Mucinex DTylenol Cold Multi-Symptom Daytime
ExpectorantDecongestantOver-the-counter
Pain reliever
Acetaminophen (APAP)
Cough suppressantDecongestantOver-the-counter
Available as
Mucinex DTylenol Cold Multi-Symptom Daytime
  • Extended release
  • Pill
  • Liquid
  • Powder
Used for (click to learn more)
Mucinex DTylenol Cold Multi-Symptom Daytime
Risk factors for serious side effects
Mucinex DTylenol Cold Multi-Symptom Daytime
  • History of high blood pressure
  • History of heart problems
  • Age 65 years or older
    Detailed Mucinex D (Guaifenesin / Pseudoephedrine) risks & warnings »
    • Taking with alcohol
    • Taking with other Tylenol-containing medicines
    • History of liver disease
    • History of high blood pressure
    • Taking MAO inhibitors
    • Using other medications that affect serotonin
    • History of chronic obstructive pulmonary disease (COPD)
    • History of smoking
    Detailed Tylenol Cold Multi-Symptom Daytime (Acetaminophen / Dextromethorphan / Phenylephrine) risks & warnings »
    Pregnancy category
    Mucinex DTylenol Cold Multi-Symptom Daytime
    NFDA pregnancy category (Unknown)

    The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

    See the FDA package insert
    NFDA pregnancy category (Unknown)

    The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

    See the FDA package insert
    Alcohol
    No specific alcohol-related info.No specific alcohol-related info.
    Food
    No specific food-related info.No specific food-related info.
    Kidneys and liver
    No specific kidneys and liver-related info.No specific kidneys and liver-related info.
    Sex
    No specific sex-related info.No specific sex-related info.
    Sleep
    No specific sleep-related info.No specific sleep-related info.
    Weight
    No specific weight-related info.No specific weight-related info.
    Upsides and benefits
    Mucinex DTylenol Cold Multi-Symptom Daytime
    • Mucinex D (Guaifenesin / Pseudoephedrine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have sinus and chest congestion.
    • Helps loosen the mucus in your airways so that you can cough it up more easily.
    • Works well to clear nasal congestion and help you breathe better.
    • Tylenol Cold Multi-Symptom Daytime (Acetaminophen / Dextromethorphan / Phenylephrine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have a stuffy nose, a cough, fever, and pain.
    • The decongestant (phenylephrine) has fewer side effects than other decongestants like pseudoephedrine. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
    • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than other pain medications like aspirin or ibuprofen.
    Downsides and risks
    Mucinex DTylenol Cold Multi-Symptom Daytime
    • Pseudoephedrine, the decongestant in Mucinex D (Guaifenesin / Pseudoephedrine), can make your heart race or make you feel anxious and restless.
    • Doesn't work as well if you use it for more than 4 days at a time.
    • Although you don't need a prescription to get Mucinex D (Guaifenesin / Pseudoephedrine), you need to show a photo ID to buy it in the drugstore.
    • Mucinex D (Guaifenesin / Pseudoephedrine) isn’t useful if you have a dry cough.
    • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
    • Phenylephrine doesn't last as long as other oral decongestants like pseudoephedrine.
    • You shouldn't use it if you have high blood pressure.
    • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
    Tips from our pharmacists for people taking the medication
    Mucinex DTylenol Cold Multi-Symptom Daytime
    • Drink plenty of fluids while taking Mucinex D (Guaifenesin / Pseudoephedrine) because liquid helps break down mucus.
    • Follow age-specific dosing instructions on how much to take. Don't take more than the recommended dose.
    • You need to show an ID to buy Mucinex D (Guaifenesin / Pseudoephedrine) in the drugstore because it contains pseudoephedrine.
    • Don't take Mucinex D (Guaifenesin / Pseudoephedrine) too close to bedtime since it can keep you awake.
    • Can cause an irregular or fast heartbeat, and can raise your blood pressure.
    • Tylenol Cold Multi-Symptom Daytime (Acetaminophen / Dextromethorphan / Phenylephrine) starts working in about 30 minutes.
    • Phenylephrine, the decongestant, can make you restless, so don't take it too close to bedtime.
    • Contains acetaminophen, also known as Tylenol or APAP. Taking too much can cause liver failure and death. Don't take more than what's recommended on the package or with other Tylenol-containing products.
    • If you get the liquid form, use the dosing cup to measure the exact amount of medicine you need.
    • Let your doctor know if your symptoms don't improve in a few days, or if you have a really bad sore throat with a fever, headache, nausea, or vomiting.
    Learn more
    More about Mucinex DSide effectsReviews & ratingsAlternativesFDA package insert
    More about Tylenol Cold Multi-Symptom DaytimeSide effectsReviews & ratingsAlternativesFDA package insert