Compare Mucinex DM vs. Mucinex D

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Mucinex Dm
(dextromethorphan / guaifenesin)

Mucinex D
(guaifenesin / pseudoephedrine)

Breaks up mucus and relieves cough. Mucinex Dm (Dextromethorphan / Guaifenesin) is okay for loosening congestion in your chest and throat, but it could prevent you from coughing the mucus up. It comes as an extended-release tablet and a short-acting liquid.Breaks up mucus and relieves congestion. Mucinex D (Guaifenesin / Pseudoephedrine) is good if you have a stuffy nose and a cough with mucus, but it could keep you up at night.
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Reviews & ratings
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Have you used Mucinex Dm (dextromethorphan / guaifenesin)?
Worth itNot sureNot worth it
Reviews for Mucinex D (guaifenesin / pseudoephedrine)
76%
+3% better vs. Mucinex Dm (dextromethorphan / guaifenesin)
41%
-32% worse vs. Mucinex Dm (dextromethorphan / guaifenesin)
7%
+6% better vs. Mucinex Dm (dextromethorphan / guaifenesin)
1249 reviews
Have you used Mucinex D (guaifenesin / pseudoephedrine)?
Worth itNot sureNot worth it
Side effects
Mucinex DMMucinex D

We haven’t found good data for Mucinex DM side effects.

FDA side effect reports for Mucinex DM »

We haven’t found good data for Mucinex D side effects.

FDA side effect reports for Mucinex D »
How it works
Mucinex DMMucinex D
Mucinex Dm (Dextromethorphan / Guaifenesin) is a combination medicine. Guaifenesin is an expectorant that breaks up and thins out mucus. Dextromethorphan is a cough suppressant.Mucinex D (Guaifenesin / Pseudoephedrine) is a combination medicine. Guaifenesin (an expectorant) breaks up and thins out mucus. Pseudoephedrine (a decongestant) clears your sinuses.
Type of medication
Mucinex DMMucinex D
Over-the-counter
Over-the-counter
Available as
Mucinex DMMucinex D
  • Pill
  • Extended release
  • Liquid
  • Extended release
Used for
Mucinex DMMucinex D
Risk factors for serious side effects
Mucinex DMMucinex D
    • Using other medications that affect serotonin
      Detailed Mucinex Dm (dextromethorphan / guaifenesin) risks & warnings »
      • History of high blood pressure
      • History of heart problems
      • Age 65 years or older
        Detailed Mucinex D (guaifenesin / pseudoephedrine) risks & warnings »
        Pregnancy

        The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

        The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

        Upsides and benefits
        Mucinex DMMucinex D
        • Mucinex Dm (Dextromethorphan / Guaifenesin) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have chest congestion and a cough.
        • Helps loosen the mucus and phlegm that builds up in productive and wet coughs.
        • The extended release version of Mucinex DM lasts up to 12 hours.
        • Mucinex D (Guaifenesin / Pseudoephedrine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have sinus and chest congestion.
        • Helps loosen the mucus in your airways so that you can cough it up more easily.
        • Works well to clear nasal congestion and help you breathe better.
        Downsides and risks
        Mucinex DMMucinex D
        • Mucinex Dm (Dextromethorphan / Guaifenesin) isn’t useful if you have a dry cough without mucus or phlegm.
        • The two medications in this product could potentially work against each other. Guaifenesin makes mucus easier to cough up, while dextromethorphan (the "DM" in Mucinex Dm (Dextromethorphan / Guaifenesin)) stops you from coughing.
        • Can cause sleepiness, dizziness, and an upset stomach.
        • Pseudoephedrine, the decongestant in Mucinex D (Guaifenesin / Pseudoephedrine), can make your heart race or make you feel anxious and restless.
        • Doesn't work as well if you use it for more than 4 days at a time.
        • Although you don't need a prescription to get Mucinex D (Guaifenesin / Pseudoephedrine), you need to show a photo ID to buy it in the drugstore.
        • Mucinex D (Guaifenesin / Pseudoephedrine) isn’t useful if you have a dry cough.
        Tips from our pharmacists for people taking the medication
        Mucinex DMMucinex D
        • Cough suppressant starts working in 15 to 30 minutes.
        • Follow age-specific dosing instructions on how much to take. Don't take more than the recommended dose.
        • Drink plenty of fluids while taking Mucinex Dm (Dextromethorphan / Guaifenesin) because liquid helps break down mucus.
        • If your cough lasts more than 7 days, call your doctor.
        • Drink plenty of fluids while taking Mucinex D (Guaifenesin / Pseudoephedrine) because liquid helps break down mucus.
        • Follow age-specific dosing instructions on how much to take. Don't take more than the recommended dose.
        • You need to show an ID to buy Mucinex D (Guaifenesin / Pseudoephedrine) in the drugstore because it contains pseudoephedrine.
        • Don't take Mucinex D (Guaifenesin / Pseudoephedrine) too close to bedtime since it can keep you awake.
        • Can cause an irregular or fast heartbeat, and can raise your blood pressure.
        Learn more
        More about Mucinex DMSide effectsReviews & ratingsAlternativesFDA package insert
        Have you used Mucinex Dm (dextromethorphan / guaifenesin)?
        Worth itNot sureNot worth it
        More about Mucinex DSide effectsReviews & ratingsAlternativesFDA package insert
        Have you used Mucinex D (guaifenesin / pseudoephedrine)?
        Worth itNot sureNot worth it