Compare Mucinex DM vs. Nyquil Cold and Flu

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Mucinex Dm
(Dextromethorphan / Guaifenesin)

Nyquil Cold And Flu
(Acetaminophen / Dextromethorphan / Doxylamine)

Breaks up mucus and relieves cough. Mucinex Dm (Dextromethorphan / Guaifenesin) is okay for loosening congestion in your chest and throat, but it could prevent you from coughing the mucus up. It comes as an extended-release tablet and a short-acting liquid.Relieves cold and flu symptoms, and helps you sleep. Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine) is a useful combination medicine that relieves cold and flu symptoms and will help you sleep. Make sure you really need all of its ingredients.
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Reviews & ratings
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Reviews for Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine)
83%
5% vs. Mucinex Dm (Dextromethorphan / Guaifenesin)
42%
46% vs. Mucinex Dm (Dextromethorphan / Guaifenesin)
6%
6% vs. Mucinex Dm (Dextromethorphan / Guaifenesin)
Side effects
Mucinex DMNyquil Cold and Flu

We haven’t found good data for Mucinex DM side effects.

FDA side effect reports for Mucinex DM »

We haven’t found good data for Nyquil Cold and Flu side effects.

FDA side effect reports for Nyquil Cold and Flu »
How it works
Mucinex DMNyquil Cold and Flu
Mucinex Dm (Dextromethorphan / Guaifenesin) is a combination medicine. Guaifenesin is an expectorant that breaks up and thins out mucus. Dextromethorphan is a cough suppressant.Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine) is a combination medicine that treats cold and flu symptoms. Acetaminophen relieves pain and reduces fever. Dextromethorphan is a cough suppressant. Doxylamine is an antihistamine that relieves a runny nose and makes you very sleepy.
Type of medication
Mucinex DMNyquil Cold and Flu
Cough suppressantExpectorantOver-the-counter
Pain reliever
APAP
Cough suppressantAntihistamine
Ethanolamine derivative
Over-the-counter
Available as
Mucinex DMNyquil Cold and Flu
  • Pill
  • Extended release
  • Liquid
  • Pill
  • Liquid
Used for (click to learn more)
Mucinex DMNyquil Cold and Flu
Risk factors for serious side effects
Mucinex DMNyquil Cold and Flu
    • Using other medications that affect serotonin
      Detailed Mucinex Dm (Dextromethorphan / Guaifenesin) risks & warnings »
      • Drinking more than 2 alcoholic beverages a day
      • Taking with other Tylenol-containing medicines
      • History of liver disease
      • Using other medications that affect serotonin
      • Taking with alcohol
      • Taking with other medicines that make you less alert
      • Age 65 years or older
      • Glaucoma
      • Benign prostatic hypertrophy (BPH)
      Detailed Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine) risks & warnings »
      Pregnancy category
      Mucinex DMNyquil Cold and Flu
      NFDA pregnancy category (Unknown)

      The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

      See the FDA package insert
      NFDA pregnancy category (Unknown)

      The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

      See the FDA package insert
      Alcohol
      No specific alcohol-related info.
      • Avoid using alcohol and other drugs that make you drowsy.
      Food
      No specific food-related info.No specific food-related info.
      Kidneys and liver
      No specific kidneys and liver-related info.No specific kidneys and liver-related info.
      Sex
      No specific sex-related info.No specific sex-related info.
      Sleep
      No specific sleep-related info.
      • The antihistamine (doxylamine) will help you sleep.
      • Avoid using alcohol and other drugs that make you drowsy.
      Weight
      No specific weight-related info.No specific weight-related info.
      Upsides and benefits
      Mucinex DMNyquil Cold and Flu
      • Mucinex Dm (Dextromethorphan / Guaifenesin) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have chest congestion and a cough.
      • Helps loosen the mucus and phlegm that builds up in productive and wet coughs.
      • The extended release version of Mucinex DM lasts up to 12 hours.
      • Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have watery eyes, a cough, fever, and pain.
      • The cough medicine (dextromethorphan) works well and has very few side effects.
      • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than other pain medications like aspirin or ibuprofen.
      • The antihistamine (doxylamine) will help you sleep.
      Downsides and risks
      Mucinex DMNyquil Cold and Flu
      • Mucinex Dm (Dextromethorphan / Guaifenesin) isn’t useful if you have a dry cough without mucus or phlegm.
      • The two medications in this product could potentially work against each other. Guaifenesin makes mucus easier to cough up, while dextromethorphan (the "DM" in Mucinex Dm (Dextromethorphan / Guaifenesin)) stops you from coughing.
      • Can cause sleepiness, dizziness, and an upset stomach.
      • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
      • You shouldn't use it if you have high blood pressure.
      • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
      Tips from our pharmacists for people taking the medication
      Mucinex DMNyquil Cold and Flu
      • Cough suppressant starts working in 15 to 30 minutes.
      • Follow age-specific dosing instructions on how much to take. Don't take more than the recommended dose.
      • Drink plenty of fluids while taking Mucinex Dm (Dextromethorphan / Guaifenesin) because liquid helps break down mucus.
      • If your cough lasts more than 7 days, call your doctor.
      • Doxylamine (the antihistamine ingredient) can make you tired, so take it close to bedtime.
      • Follow age-specific dosing instructions on how much to take. Don't take more than recommended on the package.
      • Contains acetaminophen, also known as Tylenol or APAP. Taking too much can cause liver failure and death. Don't take more than what's recommended on the package or with other Tylenol-containing products.
      • Avoid using alcohol and other drugs that make you drowsy.
      • Let your doctor know if your symptoms don't improve in a few days, or if you have a really bad sore throat with a fever, headache, nausea, or vomiting.
      Learn more
      More about Mucinex DMSide effectsReviews & ratingsAlternativesFDA package insert
      More about Nyquil Cold and FluSide effectsReviews & ratingsAlternativesFDA package insert