Compare Mucinex DM vs. Robitussin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Mucinex Dm
(Dextromethorphan / Guaifenesin)

Robitussin
(Guaifenesin)

Breaks up mucus and relieves cough. Mucinex Dm (Dextromethorphan / Guaifenesin) is okay for loosening congestion in your chest and throat, but it could prevent you from coughing the mucus up. It comes as an extended-release tablet and a short-acting liquid.Breaks up mucus that causes cough. Robitussin (Guaifenesin) is a useful medicine for loosening congestion in your chest and throat, but it doesn't last as long as other guaifenesin products.
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Reviews & ratings
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Have you used Mucinex Dm (Dextromethorphan / Guaifenesin)?
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Side effects
Mucinex DMRobitussin

We haven’t found good data for Mucinex DM side effects.

FDA side effect reports for Mucinex DM »

We haven’t found good data for Robitussin side effects.

FDA side effect reports for Robitussin »
How it works
Mucinex DMRobitussin
Mucinex Dm (Dextromethorphan / Guaifenesin) is a combination medicine. Guaifenesin is an expectorant that breaks up and thins out mucus. Dextromethorphan is a cough suppressant.Robitussin (Guaifenesin) is an expectorant. It contains guaifenesin, which thins and loosens mucus, making it easier to cough out.
Type of medication
Mucinex DMRobitussin
Cough suppressantExpectorantOver-the-counter
ExpectorantOver-the-counter
Available as
Mucinex DMRobitussin
  • Pill
  • Extended release
  • Liquid
  • Liquid
Used for (click to learn more)
Mucinex DMRobitussin
Risk factors for serious side effects
Mucinex DMRobitussin
  • Using other medications that affect serotonin
Detailed risks & warnings »
    Detailed risks & warnings »
    Pregnancy

    The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

    The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

    Upsides and benefits
    Mucinex DMRobitussin
    • Mucinex Dm (Dextromethorphan / Guaifenesin) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have chest congestion and a cough.
    • Helps loosen the mucus and phlegm that builds up in productive and wet coughs.
    • The extended release version of Mucinex DM lasts up to 12 hours.
    • Robitussin (Guaifenesin) reduces the thickness and amount of mucus in your throat and chest.
    • It’s available at the drugstore either by itself or in combination with other medications to treat cold and flu symptoms.
    • Available in multiple forms.
    • Can be used in children 12 years and older.
    Downsides and risks
    Mucinex DMRobitussin
    • Mucinex Dm (Dextromethorphan / Guaifenesin) isn’t useful if you have a dry cough without mucus or phlegm.
    • The two medications in this product could potentially work against each other. Guaifenesin makes mucus easier to cough up, while dextromethorphan (the "DM" in Mucinex Dm (Dextromethorphan / Guaifenesin)) stops you from coughing.
    • Can cause sleepiness, dizziness, and an upset stomach.
    • Robitussin (Guaifenesin) doesn't last as long as other products that contain guaifenesin. Mucinex's extended release form lasts 12 hours and Robitussin (Guaifenesin)'s lasts 8 hours.
    • You need to drink a lot of fluids while taking this medication or it won't work as well.
    • Robitussin (Guaifenesin) isn’t useful if you have a dry cough.
    • Can cause nausea, headache, and an upset stomach.
    Tips from our pharmacists for people taking the medication
    Mucinex DMRobitussin
    • Cough suppressant starts working in 15 to 30 minutes.
    • Follow age-specific dosing instructions on how much to take. Don't take more than the recommended dose.
    • Drink plenty of fluids while taking Mucinex Dm (Dextromethorphan / Guaifenesin) because liquid helps break down mucus.
    • If your cough lasts more than 7 days, call your doctor.
    • Drink plenty of fluids while taking Robitussin (Guaifenesin) because liquid helps break down mucus.
    • Steam from a humidifier, cool mist vaporizer, or hot shower can also help add moisture to your airways.
    • Follow age-specific dosing instructions on how much to take.
    • Robitussin (Guaifenesin) only works for coughs with mucus, so don't use it if you have a dry cough.
    • If your cough lasts more than 7 days, call your doctor.
    Learn more
    More about Mucinex DMSide effectsReviews & ratingsAlternativesFDA package insert
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    More about RobitussinSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Robitussin (Guaifenesin)?
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