Compare Mucinex DM vs. Tylenol Cold Multi-Symptom Daytime

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Mucinex Dm
(dextromethorphan / guaifenesin)

Tylenol Cold Multi-Symptom Daytime
(acetaminophen / dextromethorphan / phenylephrine)

Breaks up mucus and relieves cough. Mucinex Dm (Dextromethorphan / Guaifenesin) is okay for loosening congestion in your chest and throat, but it could prevent you from coughing the mucus up. It comes as an extended-release tablet and a short-acting liquid.Relieves cold and flu symptoms. Tylenol Cold Multi-Symptom Daytime (Acetaminophen / Dextromethorphan / Phenylephrine) is good for multiple cold symptoms, but it's more medicine than you need if you only have one symptom.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.4Mucinex DM
Reviews for Mucinex DM
73%
of people (All ages) say Mucinex DM is worth it
73%
say it works well
13%
say it's a big hassle
Have you used Mucinex Dm (dextromethorphan / guaifenesin)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Tylenol Cold Multi-Symptom Daytime (acetaminophen / dextromethorphan / phenylephrine)?
Worth itNot sureNot worth it
Side effects
Mucinex DMTylenol Cold Multi-Symptom Daytime

We haven’t found good data for Mucinex DM side effects.

FDA side effect reports for Mucinex DM »

We haven’t found good data for Tylenol Cold Multi-Symptom Daytime side effects.

FDA side effect reports for Tylenol Cold Multi-Symptom Daytime »
How it works
Mucinex DMTylenol Cold Multi-Symptom Daytime
Mucinex Dm (Dextromethorphan / Guaifenesin) is a combination medicine. Guaifenesin is an expectorant that breaks up and thins out mucus. Dextromethorphan is a cough suppressant.Tylenol Cold Multi-Symptom Daytime (Acetaminophen / Dextromethorphan / Phenylephrine) is a combination medicine that treats cold and flu symptoms. Acetaminophen relieves pain and reduces fever. Dextromethorphan is a cough suppressant. Phenylephrine is a decongestant that clears your sinuses.
Type of medication
Mucinex DMTylenol Cold Multi-Symptom Daytime
Over-the-counterOver-the-counter
Available as
Mucinex DMTylenol Cold Multi-Symptom Daytime
  • Pill
  • Extended release
  • Liquid
  • Pill
  • Liquid
  • Powder
Used for
Mucinex DMTylenol Cold Multi-Symptom Daytime
Risk factors for serious side effects
Mucinex DMTylenol Cold Multi-Symptom Daytime
  • Using other medications that affect serotonin
Detailed Mucinex Dm (dextromethorphan / guaifenesin) risks & warnings »
  • Taking with alcohol
  • Taking with other Tylenol-containing medicines
  • History of liver disease
  • History of high blood pressure
  • Taking MAO inhibitors
Detailed Tylenol Cold Multi-Symptom Daytime (acetaminophen / dextromethorphan / phenylephrine) risks & warnings »
Pregnancy

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

Kidneys and liver
Mucinex DMTylenol Cold Multi-Symptom Daytime
No kidneys and liver related info.
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
Pain
Mucinex DMTylenol Cold Multi-Symptom Daytime
No pain related info.
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than other pain medications like aspirin or ibuprofen.
Upsides and benefits
Mucinex DMTylenol Cold Multi-Symptom Daytime
  • Mucinex Dm (Dextromethorphan / Guaifenesin) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have chest congestion and a cough.
  • Helps loosen the mucus and phlegm that builds up in productive and wet coughs.
  • The extended release version of Mucinex DM lasts up to 12 hours.
  • Tylenol Cold Multi-Symptom Daytime (Acetaminophen / Dextromethorphan / Phenylephrine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have a stuffy nose, a cough, fever, and pain.
  • The decongestant (phenylephrine) has fewer side effects than other decongestants like pseudoephedrine. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than other pain medications like aspirin or ibuprofen.
Downsides and risks
Mucinex DMTylenol Cold Multi-Symptom Daytime
  • Mucinex Dm (Dextromethorphan / Guaifenesin) isn’t useful if you have a dry cough without mucus or phlegm.
  • The two medications in this product could potentially work against each other. Guaifenesin makes mucus easier to cough up, while dextromethorphan (the "DM" in Mucinex Dm (Dextromethorphan / Guaifenesin)) stops you from coughing.
  • Can cause sleepiness, dizziness, and an upset stomach.
  • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
  • Phenylephrine doesn't last as long as other oral decongestants like pseudoephedrine.
  • You shouldn't use it if you have high blood pressure.
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
Tips from our pharmacists for people taking the medication
Mucinex DMTylenol Cold Multi-Symptom Daytime
  • Cough suppressant starts working in 15 to 30 minutes.
  • Follow age-specific dosing instructions on how much to take. Don't take more than the recommended dose.
  • Drink plenty of fluids while taking Mucinex Dm (Dextromethorphan / Guaifenesin) because liquid helps break down mucus.
  • If your cough lasts more than 7 days, call your doctor.
  • Tylenol Cold Multi-Symptom Daytime (Acetaminophen / Dextromethorphan / Phenylephrine) starts working in about 30 minutes.
  • Phenylephrine, the decongestant, can make you restless, so don't take it too close to bedtime.
  • Contains acetaminophen, also known as Tylenol or APAP. Taking too much can cause liver failure and death. Don't take more than what's recommended on the package or with other Tylenol-containing products.
  • If you get the liquid form, use the dosing cup to measure the exact amount of medicine you need.
  • Let your doctor know if your symptoms don't improve in a few days, or if you have a really bad sore throat with a fever, headache, nausea, or vomiting.
Learn more
More about Mucinex DMSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Mucinex Dm (dextromethorphan / guaifenesin)?
Worth itNot sureNot worth it
More about Tylenol Cold Multi-Symptom DaytimeSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Tylenol Cold Multi-Symptom Daytime (acetaminophen / dextromethorphan / phenylephrine)?
Worth itNot sureNot worth it