Compare Mucinex vs. Mucinex D

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Mucinex
(guaifenesin)

Mucinex D
(guaifenesin / pseudoephedrine)

Breaks up mucus that causes cough. Mucinex (Guaifenesin) is a useful medicine for loosening congestion in your chest and throat, and it lasts longer than other guaifenesin products.Breaks up mucus and relieves congestion. Mucinex D (Guaifenesin / Pseudoephedrine) is good if you have a stuffy nose and a cough with mucus, but it could keep you up at night.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.22Mucinex
Reviews for Mucinex
78%
of people (All ages) say Mucinex is worth it
47%
say it works well
7%
say it's a big hassle
902 reviews
Have you used Mucinex (guaifenesin)?
Worth itNot sureNot worth it
Reviews for Mucinex D
76%
+2% better vs. Mucinex
41%
+6% better vs. Mucinex
7%
Same vs. Mucinex
1249 reviews
Have you used Mucinex D (guaifenesin / pseudoephedrine)?
Worth itNot sureNot worth it
Side effects
MucinexMucinex D

We haven’t found good data for Mucinex side effects.

FDA side effect reports for Mucinex »

We haven’t found good data for Mucinex D side effects.

FDA side effect reports for Mucinex D »
How it works
MucinexMucinex D
Mucinex (Guaifenesin) is an expectorant. It contains guaifenesin, which thins and loosens mucus, making it easier to cough out.Mucinex D (Guaifenesin / Pseudoephedrine) is a combination medicine. Guaifenesin (an expectorant) breaks up and thins out mucus. Pseudoephedrine (a decongestant) clears your sinuses.
Type of medication
MucinexMucinex D
Over-the-counterOver-the-counter
Available as
MucinexMucinex D
  • Extended release
  • Liquid
  • Extended release
Used for
MucinexMucinex D
Risk factors for serious side effects
MucinexMucinex D
    Detailed Mucinex (guaifenesin) risks & warnings »
    • History of high blood pressure
    • History of heart problems
    • Age 65 years or older
    Detailed Mucinex D (guaifenesin / pseudoephedrine) risks & warnings »
    Pregnancy

    The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

    The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

    Alcohol
    MucinexMucinex D
    • Mucinex (Guaifenesin) is alcohol- and sugar-free.
    No alcohol related info.
    Upsides and benefits
    MucinexMucinex D
    • Mucinex (Guaifenesin) reduces the thickness and amount of mucus in your throat and chest.
    • Lasts longer than some other products that contain guaifenesin, such as Robitussin, because it's an extended-release form.
    • It’s available at the drugstore either by itself or in combination with other medications to treat cold and flu symptoms.
    • Available in liquid and tablet forms.
    • Mucinex (Guaifenesin) is alcohol- and sugar-free.
    • Mucinex D (Guaifenesin / Pseudoephedrine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have sinus and chest congestion.
    • Helps loosen the mucus in your airways so that you can cough it up more easily.
    • Works well to clear nasal congestion and help you breathe better.
    Downsides and risks
    MucinexMucinex D
    • Mucinex (Guaifenesin) is more expensive than other medications that treat congestion.
    • You need to drink a lot of fluids while taking this medication or it won't work as well.
    • Mucinex (Guaifenesin) isn’t useful if you have a dry cough.
    • Can cause nausea, headache, and an upset stomach.
    • Pseudoephedrine, the decongestant in Mucinex D (Guaifenesin / Pseudoephedrine), can make your heart race or make you feel anxious and restless.
    • Doesn't work as well if you use it for more than 4 days at a time.
    • Although you don't need a prescription to get Mucinex D (Guaifenesin / Pseudoephedrine), you need to show a photo ID to buy it in the drugstore.
    • Mucinex D (Guaifenesin / Pseudoephedrine) isn’t useful if you have a dry cough.
    Tips from our pharmacists for people taking the medication
    MucinexMucinex D
    • Drink plenty of fluids while taking Mucinex (Guaifenesin) because liquid helps break down mucus.
    • Steam from a humidifier, cool mist vaporizer, or hot shower can also help add moisture to your airways.
    • Follow age-specific dosing instructions on how much to take.
    • If your cough lasts more than 7 days, call your doctor.
    • Mucinex (Guaifenesin) only works for coughs with mucus, so don't use it if you have a dry cough.
    • Drink plenty of fluids while taking Mucinex D (Guaifenesin / Pseudoephedrine) because liquid helps break down mucus.
    • Follow age-specific dosing instructions on how much to take. Don't take more than the recommended dose.
    • You need to show an ID to buy Mucinex D (Guaifenesin / Pseudoephedrine) in the drugstore because it contains pseudoephedrine.
    • Don't take Mucinex D (Guaifenesin / Pseudoephedrine) too close to bedtime since it can keep you awake.
    • Can cause an irregular or fast heartbeat, and can raise your blood pressure.
    Learn more
    More about MucinexSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Mucinex (guaifenesin)?
    Worth itNot sureNot worth it
    More about Mucinex DSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Mucinex D (guaifenesin / pseudoephedrine)?
    Worth itNot sureNot worth it