Compare Mucinex vs. Mucinex D

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Breaks up mucus that causes cough.

Mucinex (Guaifenesin) is a useful medicine for loosening congestion in your chest and throat, and it lasts longer than other guaifenesin products.

3.8/ 5 average rating with 902 reviewsforMucinex
Breaks up mucus and relieves congestion.

Mucinex D (Guaifenesin / Pseudoephedrine) is good if you have a stuffy nose and a cough with mucus, but it could keep you up at night.

3.8/ 5 average rating with 1249 reviewsforMucinex D
Upsides
  • Mucinex (Guaifenesin) reduces the thickness and amount of mucus in your throat and chest.
  • Lasts longer than some other products that contain guaifenesin, such as Robitussin, because it's an extended-release form.
  • It’s available at the drugstore either by itself or in combination with other medications to treat cold and flu symptoms.
  • Available in liquid and tablet forms.
  • Mucinex (Guaifenesin) is alcohol- and sugar-free.
  • Mucinex D (Guaifenesin / Pseudoephedrine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have sinus and chest congestion.
  • Helps loosen the mucus in your airways so that you can cough it up more easily.
  • Works well to clear nasal congestion and help you breathe better.
Downsides
  • Mucinex (Guaifenesin) is more expensive than other medications that treat congestion.
  • You need to drink a lot of fluids while taking this medication or it won't work as well.
  • Mucinex (Guaifenesin) isn’t useful if you have a dry cough.
  • Can cause nausea, headache, and an upset stomach.
  • Pseudoephedrine, the decongestant in Mucinex D (Guaifenesin / Pseudoephedrine), can make your heart race or make you feel anxious and restless.
  • Doesn't work as well if you use it for more than 4 days at a time.
  • Although you don't need a prescription to get Mucinex D (Guaifenesin / Pseudoephedrine), you need to show a photo ID to buy it in the drugstore.
  • Mucinex D (Guaifenesin / Pseudoephedrine) isn’t useful if you have a dry cough.
Used for
Dosage forms
  • Extended release
  • Liquid
  • Extended release
No pricing information available
No pricing information available
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Reviews
902 reviews so far
78%
saidit'sworth it
47%
saiditworked well
7%
saidit'sa big hassle

Have you used Mucinex (Guaifenesin)?

Leave a review
1249 reviews so far
76%
saidit'sworth it
41%
saiditworked well
7%
saidit'sa big hassle

Have you used Mucinex D (Guaifenesin / Pseudoephedrine)?

Leave a review
Side effects
The Mucinex (Guaifenesin) FDA package insert doesn’t have numbers about how common side effects are.
The Mucinex D (Guaifenesin / Pseudoephedrine) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • High blood pressure
    • History of high blood pressure
  • Heart problems
    • History of heart problems
    • Age 65 years or older
  • Nausea and vomiting
See more detailed risks and warnings