Compare Mucinex vs. Mucinex D

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Mucinex
(Guaifenesin)

Mucinex D
(Guaifenesin / Pseudoephedrine)

Breaks up mucus that causes cough. Mucinex (Guaifenesin) is a useful medicine for loosening congestion in your chest and throat, and it lasts longer than other guaifenesin products.Breaks up mucus and relieves congestion. Mucinex D (Guaifenesin / Pseudoephedrine) is good if you have a stuffy nose and a cough with mucus, but it could keep you up at night.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
5.226057906458798Mucinex
Reviews for Mucinex (Guaifenesin)
78%
of people say Mucinex (Guaifenesin) is worth it
47%
say it works well
7%
say it's a big hassle
Reviews for Mucinex D (Guaifenesin / Pseudoephedrine)
76%
2% vs. Mucinex (Guaifenesin)
41%
6% vs. Mucinex (Guaifenesin)
7%
Same vs. Mucinex (Guaifenesin)
Side effects
MucinexMucinex D

We haven’t found good data for Mucinex side effects.

FDA side effect reports for Mucinex »

We haven’t found good data for Mucinex D side effects.

FDA side effect reports for Mucinex D »
How it works
MucinexMucinex D
Mucinex (Guaifenesin) is an expectorant. It contains guaifenesin, which thins and loosens mucus, making it easier to cough out.Mucinex D (Guaifenesin / Pseudoephedrine) is a combination medicine. Guaifenesin (an expectorant) breaks up and thins out mucus. Pseudoephedrine (a decongestant) clears your sinuses.
Type of medication
MucinexMucinex D
ExpectorantOver-the-counter
ExpectorantDecongestantOver-the-counter
Available as
MucinexMucinex D
  • Extended release
  • Liquid
  • Extended release
Used for (click to learn more)
MucinexMucinex D
Risk factors for serious side effects
MucinexMucinex D
    Detailed Mucinex (Guaifenesin) risks & warnings »
    • History of high blood pressure
    • History of heart problems
    • Age 65 years or older
      Detailed Mucinex D (Guaifenesin / Pseudoephedrine) risks & warnings »
      Pregnancy category
      MucinexMucinex D
      Alcohol
      • Mucinex (Guaifenesin) is alcohol- and sugar-free.
      No specific alcohol-related info.
      Food
      No specific food-related info.No specific food-related info.
      Kidneys and liver
      No specific kidneys and liver-related info.No specific kidneys and liver-related info.
      Sex
      No specific sex-related info.No specific sex-related info.
      Sleep
      No specific sleep-related info.No specific sleep-related info.
      Weight
      No specific weight-related info.No specific weight-related info.
      Upsides and benefits
      MucinexMucinex D
      • Mucinex (Guaifenesin) reduces the thickness and amount of mucus in your throat and chest.
      • Lasts longer than some other products that contain guaifenesin, such as Robitussin, because it's an extended-release form.
      • It’s available at the drugstore either by itself or in combination with other medications to treat cold and flu symptoms.
      • Available in liquid and tablet forms.
      • Mucinex (Guaifenesin) is alcohol- and sugar-free.
      • Mucinex D (Guaifenesin / Pseudoephedrine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have sinus and chest congestion.
      • Helps loosen the mucus in your airways so that you can cough it up more easily.
      • Works well to clear nasal congestion and help you breathe better.
      Downsides and risks
      MucinexMucinex D
      • Mucinex (Guaifenesin) is more expensive than other medications that treat congestion.
      • You need to drink a lot of fluids while taking this medication or it won't work as well.
      • Mucinex (Guaifenesin) isn’t useful if you have a dry cough.
      • Can cause nausea, headache, and an upset stomach.
      • Pseudoephedrine, the decongestant in Mucinex D (Guaifenesin / Pseudoephedrine), can make your heart race or make you feel anxious and restless.
      • Doesn't work as well if you use it for more than 4 days at a time.
      • Although you don't need a prescription to get Mucinex D (Guaifenesin / Pseudoephedrine), you need to show a photo ID to buy it in the drugstore.
      • Mucinex D (Guaifenesin / Pseudoephedrine) isn’t useful if you have a dry cough.
      Tips from our pharmacists for people taking the medication
      MucinexMucinex D
      • Drink plenty of fluids while taking Mucinex (Guaifenesin) because liquid helps break down mucus.
      • Steam from a humidifier, cool mist vaporizer, or hot shower can also help add moisture to your airways.
      • Follow age-specific dosing instructions on how much to take.
      • If your cough lasts more than 7 days, call your doctor.
      • Mucinex (Guaifenesin) only works for coughs with mucus, so don't use it if you have a dry cough.
      • Drink plenty of fluids while taking Mucinex D (Guaifenesin / Pseudoephedrine) because liquid helps break down mucus.
      • Follow age-specific dosing instructions on how much to take. Don't take more than the recommended dose.
      • You need to show an ID to buy Mucinex D (Guaifenesin / Pseudoephedrine) in the drugstore because it contains pseudoephedrine.
      • Don't take Mucinex D (Guaifenesin / Pseudoephedrine) too close to bedtime since it can keep you awake.
      • Can cause an irregular or fast heartbeat, and can raise your blood pressure.
      Learn more
      More about MucinexSide effectsReviews & ratingsAlternativesFDA package insert
      More about Mucinex DSide effectsReviews & ratingsAlternativesFDA package insert