Compare Mucinex vs. Nyquil Cold and Flu

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Mucinex
(Guaifenesin)

Nyquil Cold And Flu
(Acetaminophen / Dextromethorphan / Doxylamine)

Breaks up mucus that causes cough. Mucinex (Guaifenesin) is a useful medicine for loosening congestion in your chest and throat, and it lasts longer than other guaifenesin products.Relieves cold and flu symptoms, and helps you sleep. Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine) is a useful combination medicine that relieves cold and flu symptoms and will help you sleep. Make sure you really need all of its ingredients.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
5.226057906458798Mucinex
Reviews for Mucinex (Guaifenesin)
78%
of people say Mucinex (Guaifenesin) is worth it
47%
say it works well
7%
say it's a big hassle
Reviews for Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine)
83%
+5% vs. Mucinex (Guaifenesin)
42%
5% vs. Mucinex (Guaifenesin)
6%
+1% vs. Mucinex (Guaifenesin)
Side effects
MucinexNyquil Cold and Flu

We haven’t found good data for Mucinex side effects.

FDA side effect reports for Mucinex »

We haven’t found good data for Nyquil Cold and Flu side effects.

FDA side effect reports for Nyquil Cold and Flu »
How it works
MucinexNyquil Cold and Flu
Mucinex (Guaifenesin) is an expectorant. It contains guaifenesin, which thins and loosens mucus, making it easier to cough out.Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine) is a combination medicine that treats cold and flu symptoms. Acetaminophen relieves pain and reduces fever. Dextromethorphan is a cough suppressant. Doxylamine is an antihistamine that relieves a runny nose and makes you very sleepy.
Type of medication
MucinexNyquil Cold and Flu
ExpectorantOver-the-counter
Pain reliever
APAP
Cough suppressantAntihistamine
Ethanolamine derivative
Over-the-counter
Available as
MucinexNyquil Cold and Flu
  • Extended release
  • Liquid
  • Pill
  • Liquid
Used for (click to learn more)
MucinexNyquil Cold and Flu
Risk factors for serious side effects
MucinexNyquil Cold and Flu
    Detailed Mucinex (Guaifenesin) risks & warnings »
    • Drinking more than 2 alcoholic beverages a day
    • Taking with other Tylenol-containing medicines
    • History of liver disease
    • Using other medications that affect serotonin
    • Taking with alcohol
    • Taking with other medicines that make you less alert
    • Age 65 years or older
    • Glaucoma
    • Benign prostatic hypertrophy (BPH)
    Detailed Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine) risks & warnings »
    Pregnancy category
    MucinexNyquil Cold and Flu
    NFDA pregnancy category (Unknown)

    The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

    See the FDA package insert
    NFDA pregnancy category (Unknown)

    The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

    See the FDA package insert
    Alcohol
    • Mucinex (Guaifenesin) is alcohol- and sugar-free.
    • Avoid using alcohol and other drugs that make you drowsy.
    Food
    No specific food-related info.No specific food-related info.
    Kidneys and liver
    No specific kidneys and liver-related info.No specific kidneys and liver-related info.
    Sex
    No specific sex-related info.No specific sex-related info.
    Sleep
    No specific sleep-related info.
    • The antihistamine (doxylamine) will help you sleep.
    • Avoid using alcohol and other drugs that make you drowsy.
    Weight
    No specific weight-related info.No specific weight-related info.
    Upsides and benefits
    MucinexNyquil Cold and Flu
    • Mucinex (Guaifenesin) reduces the thickness and amount of mucus in your throat and chest.
    • Lasts longer than some other products that contain guaifenesin, such as Robitussin, because it's an extended-release form.
    • It’s available at the drugstore either by itself or in combination with other medications to treat cold and flu symptoms.
    • Available in liquid and tablet forms.
    • Mucinex (Guaifenesin) is alcohol- and sugar-free.
    • Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have watery eyes, a cough, fever, and pain.
    • The cough medicine (dextromethorphan) works well and has very few side effects.
    • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than other pain medications like aspirin or ibuprofen.
    • The antihistamine (doxylamine) will help you sleep.
    Downsides and risks
    MucinexNyquil Cold and Flu
    • Mucinex (Guaifenesin) is more expensive than other medications that treat congestion.
    • You need to drink a lot of fluids while taking this medication or it won't work as well.
    • Mucinex (Guaifenesin) isn’t useful if you have a dry cough.
    • Can cause nausea, headache, and an upset stomach.
    • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
    • You shouldn't use it if you have high blood pressure.
    • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
    Tips from our pharmacists for people taking the medication
    MucinexNyquil Cold and Flu
    • Drink plenty of fluids while taking Mucinex (Guaifenesin) because liquid helps break down mucus.
    • Steam from a humidifier, cool mist vaporizer, or hot shower can also help add moisture to your airways.
    • Follow age-specific dosing instructions on how much to take.
    • If your cough lasts more than 7 days, call your doctor.
    • Mucinex (Guaifenesin) only works for coughs with mucus, so don't use it if you have a dry cough.
    • Doxylamine (the antihistamine ingredient) can make you tired, so take it close to bedtime.
    • Follow age-specific dosing instructions on how much to take. Don't take more than recommended on the package.
    • Contains acetaminophen, also known as Tylenol or APAP. Taking too much can cause liver failure and death. Don't take more than what's recommended on the package or with other Tylenol-containing products.
    • Avoid using alcohol and other drugs that make you drowsy.
    • Let your doctor know if your symptoms don't improve in a few days, or if you have a really bad sore throat with a fever, headache, nausea, or vomiting.
    Learn more
    More about MucinexSide effectsReviews & ratingsAlternativesFDA package insert
    More about Nyquil Cold and FluSide effectsReviews & ratingsAlternativesFDA package insert