Compare naproxen vs. Acetaminophen With Codeine

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Aleve (naproxen)

Prescription or OTC
Relieves pain, fever, and inflammation.

Aleve (naproxen) works well for treating mild to moderate pain or inflammation and lasts longer than other NSAIDs.

3.9/ 5 average rating with 978 reviewsfornaproxen
Treats mild to moderate pain.

Tylenol #3 (Acetaminophen / Codeine) is a good option to treat pain and cough as needed when over-the-counter medicines can't control the symptoms, but must make sure you don't take too much acetaminophen (Tylenol) to avoid liver problems or death.

3.7/ 5 average rating with 581 reviewsforAcetaminophen With Codeine
Upsides
  • Aleve (naproxen) is effective for treating pain, inflammation, and fever.
  • Good for relieving pain from common conditions like menstrual cramps, toothaches, backache, and arthritis.
  • It lasts longer than other NSAIDS so you don't have to take it as often.
  • Aleve (naproxen) is generally safe to use, cheap, and available over-the-counter.
  • Aleve (naproxen) causes less stomach problems than its alternatives.
  • Combination pain medicine with an opioid component (codeine) and non-opioid component (acetaminophen or Tylenol) that takes advantage of different modes of pain relieve in a single pill.
  • Provides quick relieve for mild to moderate pain to improve quality of life.
  • Good for as-needed pain and control.
  • Generally well tolerated by people, especially if taken with food to lower risk of stomach upset.
  • Lower rates of misuse compared to pure opioid medicines.
  • Can help you fall asleep easier.
Downsides
  • Aleve (naproxen) needs to be taken with food or millk to lower the chances of getting an upset stomach.
  • Like all NSAIDs, Aleve (naproxen) is as not safe for pregnant women and people who are age 60 or older compared to some alternatives.
  • It can cause serious complications like stomach bleeding and kidney problems if taken for a long period of time.
  • Like all NSAIDs, Aleve (naproxen) can raise your risk of getting blood clots, a heart attack, or stroke.
  • Dizziness and drowsiness is common, but your body may adjust.
  • Everyone will get constipation - always stay hydrated and take stool softener or stimulant on days you're taking Acetaminophen with codeine if you need.
  • All opioid containing medicines have the risk of physical dependence and possibility of withdrawal when used long-term.
  • The non-opioid part of Acetaminophen with codeine, acetaminophen (Tylenol), has a high risk of liver failure and death if you take more than the maximum daily dose. Be very careful.
  • Relies on the users to be aware of how much acetaminophen (Tylenol) they are using since it is a very common ingredient in many prescription and non-prescription pain medicines.
  • Avoid alcohol.
Used for
Dosage forms
  • Pill
  • Delayed-release pill
  • Extended-release pill
  • Suspension
  • Pill
  • Liquid
Price
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Reviews
978 reviews so far
78%
saidit'sworth it
48%
saiditworked well
5%
saidit'sa big hassle

Have you used Aleve (naproxen)?

Leave a review
581 reviews so far
69%
saidit'sworth it
41%
saiditworked well
9%
saidit'sa big hassle

Have you used Tylenol #3 (Acetaminophen / Codeine)?

Leave a review
Side effects
The Aleve (naproxen) FDA package insert doesn’t have numbers about how common side effects are.
The Tylenol #3 (Acetaminophen / Codeine) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Heart attack and stroke
    • History of heart problems
    • Taking the medicine for a long period of time
  • Stomach bleeding
    • History of stomach bleeding or ulcer
    • Age 60 or older
    • Taking aspirin, other NSAIDs, or blood thinners
    • Drinking more than 3 alcoholic beverages a day
    • Smoking
    • Taking the medicine for a long period of time
  • Severe allergic reaction
    • Asthma
    • Nasal polyps
    • Aspirin allergy
    • NSAID allergy
  • Kidney damage
    • Kidney disease
    • Heart failure
    • Taking certain high blood pressure medications
    • Age 60 or older
    • Taking the medicine for a long period of time
  • Harm to fetus (unborn baby)
    • Women who want to or can become pregnant
    • Pregnant women
See more detailed risks and warnings
No information currently available