Compare Naproxen vs. Lodine

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Aleve
(naproxen)

Lodine
(etodolac)

Relieves pain, fever, and inflammation. Aleve (Naproxen) works well for mild to moderate pain and inflammation, and it lasts longer than other NSAIDs.Coming soon.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.31Naproxen
Reviews for Naproxen
78%
of people (All ages) say Naproxen is worth it
48%
say it works well
5%
say it's a big hassle
978 reviews
Have you used Aleve (naproxen)?
Worth itNot sureNot worth it

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Have you used Lodine (etodolac)?
Worth itNot sureNot worth it
Side effects
NaproxenLodine

The Naproxen FDA package insert doesn’t have numbers about how common side effects are.

More about Naproxen side effects »

We haven’t found good data for Lodine side effects.

FDA side effect reports for Lodine »
How it works
NaproxenLodine
Aleve (Naproxen) is a non-steroidal anti-inflammatory drug (NSAID). It blocks the inflammation process in your body, which relieves swelling and pain.Coming soon.
Type of medication
NaproxenLodine
Prescription or OTC
Available as
NaproxenLodine
  • Pill
  • Delayed release tablet
  • Liquid
  • Pill
  • Extended release
Used for
NaproxenLodine
  • Juvenile Rheumatoid Arthritis Osteoarthritis Pain Rheumatoid Arthritis
Risk factors for serious side effects
NaproxenLodine
  • History of heart problems
  • High blood pressure
  • High cholesterol
  • Diabetes
  • Smoking
Detailed Aleve (naproxen) risks & warnings »
    Coming soon.
    Pregnancy

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Food
    NaproxenLodine
    • Take it with a meal or a snack to prevent an upset stomach.
    • It needs to be taken with food to avoid getting an upset stomach.
    No food related info.
    Kidneys and liver
    NaproxenLodine
    • Aleve (Naproxen) is an NSAID that can lower kidney function or cause damage. Taking the lowest dose for the shortest amount of time lowers your risk. Your doctor should check your kidney function if you take Aleve (Naproxen) for any amount of time.
    • Can hurt your kidneys, so don't use it if you have a history of kidney problems.
    • It can cause serious kidney and stomach problems (like ulcers and bleeding) the longer you take it.
    No kidneys and liver related info.
    Pain
    NaproxenLodine
    • Starts relieving pain in 30 to 60 minutes.
    • Works well to relieve pain, swelling, and fevers.
    No pain related info.
    Upsides and benefits
    NaproxenLodine
    • Works well to relieve pain, swelling, and fevers.
    • Good for menstrual cramps, toothaches, body aches, and mild arthritis pain.
    • Lasts longer than Ibuprofen, so you can take it less often.
    • Aleve (Naproxen) works as well as Aspirin and Indomethacin to treat arthritis pain, and causes fewer stomach problems.
    • Although not without side effects, it's been around for a long time and is generally safe for short-term use.
    Coming soon
    Downsides and risks
    NaproxenLodine
    • It needs to be taken with food to avoid getting an upset stomach.
    • Can't be taken by pregnant women.
    • It can cause serious kidney and stomach problems (like ulcers and bleeding) the longer you take it.
    • Like all NSAIDs, it can raise your risk of having blood clots, heart attack, or stroke.
    Coming soon
    Tips from our pharmacists for people taking the medication
    NaproxenLodine
    • Starts relieving pain in 30 to 60 minutes.
    • Take it with a meal or a snack to prevent an upset stomach.
    • Can make you bruise or bleed more easily and it can also cause stomach ulcers.
    • Don't take it with other blood thinners, like aspirin, unless your doctor tells you it's safe.
    • Can hurt your kidneys, so don't use it if you have a history of kidney problems.
    Coming soon
    Learn more
    More about NaproxenSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Aleve (naproxen)?
    Worth itNot sureNot worth it
    More about LodineSide effectsReviews & ratingsFDA package insert
    Have you used Lodine (etodolac)?
    Worth itNot sureNot worth it