Compare Naproxen vs. Morphine Sulfate

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Aleve
(naproxen)

Ms Contin
(morphine sulfate)

Relieves pain, fever, and inflammation. Aleve (Naproxen) works well for mild to moderate pain and inflammation, and it lasts longer than other NSAIDs.Treats severe pain. Ms Contin (Morphine Sulfate) provides good long-term pain control without the need to take medicine frequently, but watch out for constipation.
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Reviews & ratings
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5.31Naproxen
Reviews for Aleve (naproxen)
78%
of people (All ages) say Aleve (naproxen) is worth it
48%
say it works well
5%
say it's a big hassle
978 reviews
Have you used Aleve (naproxen)?
Worth itNot sureNot worth it
Reviews for Ms Contin (morphine sulfate)
55%
-23% worse vs. Aleve (naproxen)
43%
-5% worse vs. Aleve (naproxen)
20%
-15% worse vs. Aleve (naproxen)
541 reviews
Have you used Ms Contin (morphine sulfate)?
Worth itNot sureNot worth it
Side effects
NaproxenMorphine Sulfate

The Naproxen FDA package insert doesn’t have numbers about how common side effects are.

More about Naproxen side effects »

The Morphine Sulfate FDA package insert doesn’t have numbers about how common side effects are.

More about Morphine Sulfate side effects »
How it works
NaproxenMorphine Sulfate
Aleve (Naproxen) is a non-steroidal anti-inflammatory drug (NSAID). It blocks the inflammation process in your body, which relieves swelling and pain.Ms Contin (Morphine Sulfate) is an opioid medicine that works in the brain to lower pain perception.
Type of medication
NaproxenMorphine Sulfate
Prescription or OTC
Prescription only
Available as
NaproxenMorphine Sulfate
  • Pill
  • Delayed release tablet
  • Liquid
  • Pill
  • Extended release
  • Oral solution
  • Liquid
  • Suppository
Used for
NaproxenMorphine Sulfate
Risk factors for serious side effects
NaproxenMorphine Sulfate
  • History of heart problems
  • High blood pressure
  • High cholesterol
  • Diabetes
  • Smoking
  • History of stomach bleeding or ulcers
  • Age 60 years or older
  • Taking aspirin, NSAIDs, or blood thinners
  • Drinking more than 3 alcoholic beverages a day
  • Hemophilia
  • von Willebrand's disease
  • Low blood platelet count
  • Taking anticoagulant medications
  • Asthma
  • Rhinitis
  • Nasal polyps
  • Aspirin allergy
  • NSAID allergy
  • Kidney disease
  • Heart failure
  • Liver disease
  • Taking high blood pressure medications
  • Age 65 years or older
  • Women of childbearing age
Detailed Aleve (naproxen) risks & warnings »
  • Current use of medicine that affects liver enzyme CYP 3A4
  • Age 65 or greater
  • Higher dose
  • People with not enough thyroid hormones
  • History of lung problems
  • Children age 18 and younger
  • Long-term use during pregnancy
  • Taking more than the prescribed dose
  • Long-term use
  • History of drug abuse
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • Age 65 or greater
  • Age 65 years or older
Detailed Ms Contin (morphine sulfate) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Food
NaproxenMorphine Sulfate
  • It needs to be taken with food to avoid getting an upset stomach.
  • Take it with a meal or a snack to prevent an upset stomach.
  • Take it with food to lower the chance of an upset stomach.
Kidneys and liver
NaproxenMorphine Sulfate
  • It can cause serious kidney and stomach problems (like ulcers and bleeding) the longer you take it.
  • Can hurt your kidneys, so don't use it if you have a history of kidney problems.
  • Aleve (Naproxen) is an NSAID that can lower kidney function or cause damage. Taking the lowest dose for the shortest amount of time lowers your risk. Your doctor should check your kidney function if you take Aleve (Naproxen) for any amount of time.
No kidneys and liver related info.
Pain
NaproxenMorphine Sulfate
  • Works well to relieve pain, swelling, and fevers.
  • Starts relieving pain in 30 to 60 minutes.
  • Can hurt your kidneys, so don't use it if you have a history of kidney problems.
  • Good for chronic pain that requires around-the-clock relief.
  • Doesn't work for as-needed or quick pain relief.
Sleep
NaproxenMorphine Sulfate
No sleep related info.
  • Dizziness and drowsiness is common, but your body may adjust.
Upsides and benefits
NaproxenMorphine Sulfate
  • Works well to relieve pain, swelling, and fevers.
  • Good for menstrual cramps, toothaches, body aches, and mild arthritis pain.
  • Lasts longer than Ibuprofen, so you can take it less often.
  • Aleve (Naproxen) works as well as Aspirin and Indomethacin to treat arthritis pain, and causes fewer stomach problems.
  • Although not without side effects, it's been around for a long time and is generally safe for short-term use.
  • Provides longer relieve for moderate to severe pain to improve quality of life.
  • Good for chronic pain that requires around-the-clock relief.
  • Might have fewer side effects than other opioid pain relievers.
Downsides and risks
NaproxenMorphine Sulfate
  • It needs to be taken with food to avoid getting an upset stomach.
  • Can't be taken by pregnant women.
  • It can cause serious kidney and stomach problems (like ulcers and bleeding) the longer you take it.
  • Like all NSAIDs, it can raise your risk of having blood clots, heart attack, or stroke.
  • Doesn't work for as-needed or quick pain relief.
  • Dizziness and drowsiness is common, but your body may adjust.
  • Everyone will get constipation - always stay hydrated and take stool softener or stimulant on days you're taking Ms Contin (Morphine Sulfate) if you need.
  • Long term use will likely cause physical dependence.
  • Must be weaned slowly off the medicine after use longer than 2 weeks.
Tips from our pharmacists for people taking the medication
NaproxenMorphine Sulfate
  • Starts relieving pain in 30 to 60 minutes.
  • Take it with a meal or a snack to prevent an upset stomach.
  • Can make you bruise or bleed more easily and it can also cause stomach ulcers.
  • Don't take it with other blood thinners, like aspirin, unless your doctor tells you it's safe.
  • Can hurt your kidneys, so don't use it if you have a history of kidney problems.
  • Opioid pain medicine that provides longer pain relief—up to 12 hours.
  • Works best when taken regularly instead of as-needed.
  • Especially useful for people with chronic pain problems.
  • May not be the best choice for people who have never taken an opioid pain medicine because it lasts so long.
  • Swallow it whole. Don't crush, chew, or split the medicine.
  • Can make you dizzy or drowsy.
  • Avoid activities that need you to be fully alert until you know how it affects you.
  • Take it with food to lower the chance of an upset stomach.
  • Constipation is common and may not go away while you're taking this medicine. Drinking lots of water and taking laxatives can help.
  • Talk to your doctor if it doesn't help enough for your pain, or if the side effects are really bad.
Learn more
More about NaproxenSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Aleve (naproxen)?
Worth itNot sureNot worth it
More about Morphine SulfateSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Ms Contin (morphine sulfate)?
Worth itNot sureNot worth it