Compare Naproxen vs. Norco

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Aleve
(Naproxen)

Norco
(Hydrocodone / Acetaminophen)

Relieves pain, fever, and inflammation. Aleve (Naproxen) works well for mild to moderate pain and inflammation, and it lasts longer than other NSAIDs.Treats moderate to severe pain. Norco (Hydrocodone / Acetaminophen) is a good option to treat pain as needed when over-the-counter medicines can't control the symptoms, but must make sure you don't take too much acetaminophen (Tylenol) to avoid liver problems or death.
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.31Naproxen
Reviews for Aleve (Naproxen)
78%
of people (All ages) say Aleve (Naproxen) is worth it
48%
say it works well
5%
say it's a big hassle
978 reviews
Have you used Aleve (Naproxen)?
Worth itNot sureNot worth it
Reviews for Norco (Hydrocodone / Acetaminophen)
67%
-11% worse vs. Aleve (Naproxen)
44%
-4% worse vs. Aleve (Naproxen)
13%
-8% worse vs. Aleve (Naproxen)
1194 reviews
Have you used Norco (Hydrocodone / Acetaminophen)?
Worth itNot sureNot worth it
Side effects
NaproxenNorco

The Naproxen FDA package insert doesn’t have numbers about how common side effects are.

More about Naproxen side effects »

The Norco FDA package insert doesn’t have numbers about how common side effects are.

More about Norco side effects »
How it works
NaproxenNorco
Aleve (Naproxen) is a non-steroidal anti-inflammatory drug (NSAID). It blocks the inflammation process in your body, which relieves swelling and pain.Norco (Hydrocodone / Acetaminophen) is a combination pain medicine. Hydrocodone is an opioid (similar to morphine) that works in the brain to lower pain perception. Acetaminophen is a non-opioid pain reliever and fever reducer.
Type of medication
NaproxenNorco
Prescription or OTC
Prescription only
Available as
NaproxenNorco
  • Pill
  • Delayed release tablet
  • Liquid
  • Pill
  • Oral solution
Used for
NaproxenNorco
Risk factors for serious side effects
NaproxenNorco
  • History of heart problems
  • High blood pressure
  • High cholesterol
  • Diabetes
  • Smoking
  • History of stomach bleeding or ulcers
  • Age 60 years or older
  • Taking aspirin, NSAIDs, or blood thinners
  • Drinking more than 3 alcoholic beverages a day
  • Hemophilia
  • von Willebrand's disease
  • Low blood platelet count
  • Taking anticoagulant medications
  • Asthma
  • Rhinitis
  • Nasal polyps
  • Aspirin allergy
  • NSAID allergy
  • Kidney disease
  • Heart failure
  • Liver disease
  • Taking high blood pressure medications
  • Age 65 years or older
  • Women of childbearing age
Detailed Aleve (Naproxen) risks & warnings »
  • Current liver disease
  • Taking with alcohol
  • Taking other medicines with acetaminophen
  • Age 65 or greater
  • Higher dose
  • People with not enough thyroid hormones
  • History of lung problems
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • Age 65 or greater
    • Long-term use of opioids in mother
    • Breastfeeding while taking Norco (Hydrocodone / Acetaminophen)
    • Taking more than the prescribed dose
    • Long-term use
    • History of drug abuse
    Detailed Norco (Hydrocodone / Acetaminophen) risks & warnings »
    Pregnancy

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Alcohol
    NaproxenNorco
    No alcohol related info.
    • Avoid alcohol.
    Food
    NaproxenNorco
    • It needs to be taken with food to avoid getting an upset stomach.
    • Take it with a meal or a snack to prevent an upset stomach.
    • Take it with food to lower the chance of an upset stomach.
    Kidneys and liver
    NaproxenNorco
    • It can cause serious kidney and stomach problems (like ulcers and bleeding) the longer you take it.
    • Can hurt your kidneys, so don't use it if you have a history of kidney problems.
    • Aleve (Naproxen) is an NSAID that can lower kidney function or cause damage. Taking the lowest dose for the shortest amount of time lowers your risk. Your doctor should check your kidney function if you take Aleve (Naproxen) for any amount of time.
    • Don't take more than instructed to prevent liver damage.
    • The acetaminophen component in Norco (Hydrocodone / Acetaminophen) can hurt your liver. Using more than 4000 mg of the acetaminophen (or 12 tablets of Norco (Hydrocodone / Acetaminophen) can cause serious harm to your liver. You may develop life-threatening liver problems that need a liver transplant. Don't take more than your doctor prescribes, and avoid other medicines that have acetaminophen when using Norco (Hydrocodone / Acetaminophen).
    Pain
    NaproxenNorco
    • Works well to relieve pain, swelling, and fevers.
    • Starts relieving pain in 30 to 60 minutes.
    • Can hurt your kidneys, so don't use it if you have a history of kidney problems.
    • Combination pain medicine with an opiod component (hydrocodone) and non-opioid component (acetaminophen or Tylenol) that takes advantage of different modes of pain relieve in a single pill.
    • This is a combination pain medication. It contains both an opioid medicine and acetaminophen (Tylenol).
    • Works best if you take it as soon as you start feeling pain. Starts working in 30 minutes and pain relief lasts 4 to 6 hours.
    • Talk to your doctor if it doesn't work well enough to relieve your pain, or if the side effects are really bad.
    Sleep
    NaproxenNorco
    No sleep related info.
    • Can help you fall asleep easier.
    • Dizziness and drowsiness is common.
    Upsides and benefits
    NaproxenNorco
    • Works well to relieve pain, swelling, and fevers.
    • Good for menstrual cramps, toothaches, body aches, and mild arthritis pain.
    • Lasts longer than Ibuprofen, so you can take it less often.
    • Aleve (Naproxen) works as well as Aspirin and Indomethacin to treat arthritis pain, and causes fewer stomach problems.
    • Although not without side effects, it's been around for a long time and is generally safe for short-term use.
    • Combination pain medicine with an opiod component (hydrocodone) and non-opioid component (acetaminophen or Tylenol) that takes advantage of different modes of pain relieve in a single pill.
    • Provides quick relief for moderate to severe pain to improve quality of life.
    • Good for as-needed, short-term use, but may be helpful to manage more long-term pain problems if used at the appropriate doses and intervals.
    • Generally well tolerated by people, especially if taken with food to lower risk of stomach upset.
    • Lower rates of misuse compared to pure opioid medicines.
    • Can help you fall asleep easier.
    Downsides and risks
    NaproxenNorco
    • It needs to be taken with food to avoid getting an upset stomach.
    • Can't be taken by pregnant women.
    • It can cause serious kidney and stomach problems (like ulcers and bleeding) the longer you take it.
    • Like all NSAIDs, it can raise your risk of having blood clots, heart attack, or stroke.
    • Dizziness and drowsiness is common.
    • Everyone will get constipation - always stay hydrated and take stool softener or stimulant on days you're taking Norco if you need.
    • All opioid containing medicines have the risk of physical dependence and possibility of withdrawal when used long-term.
    • The non-opioid part of Norco, acetaminophen (Tylenol), has a high risk of liver failure and death if you take more than the maximum daily dose. Be very careful.
    • Relies on the users to be aware of how much acetaminophen (Tylenol) they are using since it is a very common ingredient in many prescription and non-prescription pain medicines.
    • Avoid alcohol.
    Tips from our pharmacists for people taking the medication
    NaproxenNorco
    • Starts relieving pain in 30 to 60 minutes.
    • Take it with a meal or a snack to prevent an upset stomach.
    • Can make you bruise or bleed more easily and it can also cause stomach ulcers.
    • Don't take it with other blood thinners, like aspirin, unless your doctor tells you it's safe.
    • Can hurt your kidneys, so don't use it if you have a history of kidney problems.
    • This is a combination pain medication. It contains both an opioid medicine and acetaminophen (Tylenol).
    • Works best if you take it as soon as you start feeling pain. Starts working in 30 minutes and pain relief lasts 4 to 6 hours.
    • Can make you dizzy or drowsy. Avoid activities need you to be fully alert until you know how it affects you.
    • Take it with food to lower the chance of an upset stomach.
    • Constipation is common and may not go away while you're taking this medicine. Drinking lots of water and using laxatives can help.
    • Don't take more than instructed to prevent liver damage.
    • Use it for the shortest time and at the lowest dose possible, to lower your chance of becoming addicted.
    • Talk to your doctor if it doesn't work well enough to relieve your pain, or if the side effects are really bad.
    Learn more
    More about NaproxenSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Aleve (Naproxen)?
    Worth itNot sureNot worth it
    More about NorcoSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Norco (Hydrocodone / Acetaminophen)?
    Worth itNot sureNot worth it