Compare Naproxen vs. Percocet

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Aleve
(naproxen)

Percocet
(oxycodone / acetaminophen)

Relieves pain, fever, and inflammation. Aleve (Naproxen) works well for mild to moderate pain and inflammation, and it lasts longer than other NSAIDs.Treats moderate to severe pain. Percocet (Oxycodone / Acetaminophen) is the strongest prescription combination pain medicine for as needed pain relief, but make sure you don't take too much acetaminophen (Tylenol) to avoid liver problems or death.
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Coupons for Naproxen
Best available price for 60 (500mg) tablets of naproxen
Coupons for Percocet
Best available price for 120 (5mg/325mg) tablets of percocet
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.31Naproxen
Reviews for Naproxen
78%
of people (All ages) say Naproxen is worth it
48%
say it works well
5%
say it's a big hassle
978 reviews
Have you used Aleve (naproxen)?
Worth itNot sureNot worth it
Reviews for Percocet
70%
+8% better vs. Naproxen
49%
-1% worse vs. Naproxen
15%
+10% better vs. Naproxen
1399 reviews
Have you used Percocet (oxycodone / acetaminophen)?
Worth itNot sureNot worth it
Side effects
NaproxenPercocet

The Naproxen FDA package insert doesn’t have numbers about how common side effects are.

More about Naproxen side effects »

The Percocet FDA package insert doesn’t have numbers about how common side effects are.

More about Percocet side effects »
How it works
NaproxenPercocet
Aleve (Naproxen) is a non-steroidal anti-inflammatory drug (NSAID). It blocks the inflammation process in your body, which relieves swelling and pain.Percocet (Oxycodone / Acetaminophen) is a combination pain medicine. Oxycodone is an opioid (similar to morphine) that works in the brain to lower pain perception. Acetaminophen is a non-opioid pain reliever and fever reducer.
Type of medication
NaproxenPercocet
Prescription or OTCPrescription only
Available as
NaproxenPercocet
  • Pill
  • Delayed release tablet
  • Liquid
  • Pill
  • Oral solution
Used for
NaproxenPercocet
Risk factors for serious side effects
NaproxenPercocet
  • History of heart problems
  • High blood pressure
  • High cholesterol
  • Diabetes
  • Smoking
Detailed Aleve (naproxen) risks & warnings »
  • Current liver disease
  • Taking with alcohol
  • Taking other medicines with acetaminophen
  • Age 65 or greater
  • Higher dose
Detailed Percocet (oxycodone / acetaminophen) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Alcohol
NaproxenPercocet
No alcohol related info.
  • Avoid alcohol.
Food
NaproxenPercocet
  • Take it with a meal or a snack to prevent an upset stomach.
  • It needs to be taken with food to avoid getting an upset stomach.
  • Take it with food to lower the chance of an upset stomach.
Kidneys and liver
NaproxenPercocet
  • Aleve (Naproxen) is an NSAID that can lower kidney function or cause damage. Taking the lowest dose for the shortest amount of time lowers your risk. Your doctor should check your kidney function if you take Aleve (Naproxen) for any amount of time.
  • Can hurt your kidneys, so don't use it if you have a history of kidney problems.
  • It can cause serious kidney and stomach problems (like ulcers and bleeding) the longer you take it.
  • The acetaminophen component in Percocet (Oxycodone / Acetaminophen) can hurt your liver. Using more than 4000 mg of the acetaminophen (or 12 tablets of Percocet (Oxycodone / Acetaminophen) can cause serious harm to your liver that may make you need a liver transplant and can be life-threatening. Don't take more than your doctor prescribes, and avoid other medicines that have acetaminophen when using Percocet (Oxycodone / Acetaminophen).
  • Don't take more than instructed to prevent liver damage.
Pain
NaproxenPercocet
  • Starts relieving pain in 30 to 60 minutes.
  • Works well to relieve pain, swelling, and fevers.
  • This is a combination pain medication. It contains both an opioid medicine, and acetaminophen (Tylenol).
  • Works best if you take it as soon as you start feeling pain.
  • Pain relief lasts 4-6 hours.
  • Talk to your doctor if it doesn't work well enough to relieve your pain, or if the side effects are really bad.
  • Combination pain medicine with an opioid component (oxycodone) and non-opioid component (acetaminophen or Tylenol) that takes advantage of different modes of pain relieve in a single pill.
  • Generally considered stronger than Norco or other combination pain medicine for treating pain.
Sleep
NaproxenPercocet
No sleep related info.
  • Can help you fall asleep easier.
  • Dizziness and drowsiness is common, but your body may adjust.
Upsides and benefits
NaproxenPercocet
  • Works well to relieve pain, swelling, and fevers.
  • Good for menstrual cramps, toothaches, body aches, and mild arthritis pain.
  • Lasts longer than Ibuprofen, so you can take it less often.
  • Aleve (Naproxen) works as well as Aspirin and Indomethacin to treat arthritis pain, and causes fewer stomach problems.
  • Although not without side effects, it's been around for a long time and is generally safe for short-term use.
  • Combination pain medicine with an opioid component (oxycodone) and non-opioid component (acetaminophen or Tylenol) that takes advantage of different modes of pain relieve in a single pill.
  • Provides quick relief for moderate to severe pain to improve quality of life.
  • Generally considered stronger than Norco or other combination pain medicine for treating pain.
  • Good for as-needed, short-term use, but may be helpful to manage more long-term pain problems if used at the appropriate doses and intervals.
  • Lower rates of misuse compared to pure opioid medicines.
  • Can help you fall asleep easier.
Downsides and risks
NaproxenPercocet
  • It needs to be taken with food to avoid getting an upset stomach.
  • Can't be taken by pregnant women.
  • It can cause serious kidney and stomach problems (like ulcers and bleeding) the longer you take it.
  • Like all NSAIDs, it can raise your risk of having blood clots, heart attack, or stroke.
  • Dizziness and drowsiness is common, but your body may adjust.
  • Everyone will get constipation - always stay hydrated and take stool softener or stimulant on days you're taking Percocet if you need.
  • All opioid containing medicines have the risk of physical dependence and possibility of withdrawal when used long-term.
  • The non-opioid part of Percocet, acetaminophen (Tylenol), has a high risk of liver failure and death if you take more than the maximum daily dose. Be very careful.
  • Relies on the users to be aware of how much acetaminophen (Tylenol) they are using since it is a very common ingredient in many prescription and non-prescription pain medicines.
  • Avoid alcohol.
Tips from our pharmacists for people taking the medication
NaproxenPercocet
  • Starts relieving pain in 30 to 60 minutes.
  • Take it with a meal or a snack to prevent an upset stomach.
  • Can make you bruise or bleed more easily and it can also cause stomach ulcers.
  • Don't take it with other blood thinners, like aspirin, unless your doctor tells you it's safe.
  • Can hurt your kidneys, so don't use it if you have a history of kidney problems.
  • This is a combination pain medication. It contains both an opioid medicine, and acetaminophen (Tylenol).
  • Starts working in 30 minutes.
  • Works best if you take it as soon as you start feeling pain.
  • Pain relief lasts 4-6 hours.
  • Can make you dizzy or drowsy.
  • Avoid activities need you to be fully alert until you know how it affects you.
  • Take it with food to lower the chance of an upset stomach.
  • Constipation is common and may not go away while you're taking this medicine. Drinking lots of water and using laxatives can help.
  • Don't take more than instructed to prevent liver damage.
  • Use it for the shortest time possible, and at the lowest dose possible, to lower your chance of becoming addicted.
  • Talk to your doctor if it doesn't work well enough to relieve your pain, or if the side effects are really bad.
Learn more
More about NaproxenSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Aleve (naproxen)?
Worth itNot sureNot worth it
More about PercocetSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Percocet (oxycodone / acetaminophen)?
Worth itNot sureNot worth it