Compare Naproxen vs. Percocet

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Aleve (Naproxen)

Prescription or OTC
Relieves pain, fever, and inflammation.

Aleve (Naproxen) works well for mild to moderate pain and inflammation, and it lasts longer than other NSAIDs.

5.3/ 7 average rating with 978 reviewsforNaproxen
Treats moderate to severe pain.

Percocet (Oxycodone / Acetaminophen) is the strongest prescription combination pain medicine for as needed pain relief, but make sure you don't take too much acetaminophen (Tylenol) to avoid liver problems or death.

5.2/ 7 average rating with 1399 reviewsforPercocet
Upsides
  • Works well to relieve pain, swelling, and fevers.
  • Good for menstrual cramps, toothaches, body aches, and mild arthritis pain.
  • Lasts longer than Ibuprofen, so you can take it less often.
  • Aleve (Naproxen) works as well as Aspirin and Indomethacin to treat arthritis pain, and causes fewer stomach problems.
  • Although not without side effects, it's been around for a long time and is generally safe for short-term use.
  • Combination pain medicine with an opioid component (oxycodone) and non-opioid component (acetaminophen or Tylenol) that takes advantage of different modes of pain relieve in a single pill.
  • Provides quick relief for moderate to severe pain to improve quality of life.
  • Generally considered stronger than Norco or other combination pain medicine for treating pain.
  • Good for as-needed, short-term use, but may be helpful to manage more long-term pain problems if used at the appropriate doses and intervals.
  • Lower rates of misuse compared to pure opioid medicines.
  • Can help you fall asleep easier.
Downsides
  • It needs to be taken with food to avoid getting an upset stomach.
  • Can't be taken by pregnant women.
  • It can cause serious kidney and stomach problems (like ulcers and bleeding) the longer you take it.
  • Like all NSAIDs, it can raise your risk of having blood clots, heart attack, or stroke.
  • Dizziness and drowsiness is common, but your body may adjust.
  • Everyone will get constipation - always stay hydrated and take stool softener or stimulant on days you're taking Percocet if you need.
  • All opioid containing medicines have the risk of physical dependence and possibility of withdrawal when used long-term.
  • The non-opioid part of Percocet, acetaminophen (Tylenol), has a high risk of liver failure and death if you take more than the maximum daily dose. Be very careful.
  • Relies on the users to be aware of how much acetaminophen (Tylenol) they are using since it is a very common ingredient in many prescription and non-prescription pain medicines.
  • Avoid alcohol.
Used for
Dosage forms
  • Pill
  • Delayed release tablet
  • Liquid
  • Pill
  • Oral solution
Price
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$4
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$24.06
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Reviews
978 
78%
think this treatment is worth it
48%
think this treatment works well
5%
think this treatment is a hassle

Have you used Aleve (Naproxen)?

Leave a review
1399 
70%
think this treatment is worth it
49%
think this treatment works well
15%
think this treatment is a hassle

Have you used Percocet (Oxycodone / Acetaminophen)?

Leave a review
Side effects
The Aleve (Naproxen) FDA package insert doesn’t have numbers about how common side effects are.
The Percocet (Oxycodone / Acetaminophen) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Heart attack or stroke

    History of heart problems

    ...and 4 more risk factors

  • Stomach bleeding

    History of stomach bleeding or ulcers

    ...and 3 more risk factors

  • Bruising or bleeding

    Hemophilia

    ...and 3 more risk factors

  • Serious allergic reactions

    Asthma

    ...and 4 more risk factors

  • Lower kidney function

    Kidney disease

    ...and 4 more risk factors

  • Harm to fetus

    Women of childbearing age

See more detailed risks and warnings
  • Death from liver failure

    Current liver disease

    ...and 2 more risk factors

  • Death from lack of oxygen to the body (respiratory depression)

    Age 65 or greater

    ...and 3 more risk factors

  • Driving impairment

    Taking with alcohol

    ...and 2 more risk factors

  • Tolerance and dependence

    Taking more than the prescribed dose

    ...and 2 more risk factors

  • Neonatal withdrawal syndrome

    Long-term use of opioids in mother

    ...and 1 more risk factors

  • Death from overdose (extended-release tablet)

    Children age 18 and younger

    ...and 2 more risk factors

  • Low blood pressure

    Age 65 years or older

    ...and 1 more risk factors

See more detailed risks and warnings