Compare Naproxen vs. tramadol

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Aleve (Naproxen)

Prescription or OTC

Ultram (tramadol)

Prescription only
Relieves pain, fever, and inflammation.

Aleve (Naproxen) works well for mild to moderate pain and inflammation, and it lasts longer than other NSAIDs.

5.3/ 7 average rating with 978 reviewsforNaproxen
Treats moderate to severe pain.

Ultram (tramadol) works well for pain. Although it's a little weaker than other opioids, it can still be addictive.

4.6/ 7 average rating with 642 reviewsfortramadol
  • Works well to relieve pain, swelling, and fevers.
  • Good for menstrual cramps, toothaches, body aches, and mild arthritis pain.
  • Lasts longer than Ibuprofen, so you can take it less often.
  • Aleve (Naproxen) works as well as Aspirin and Indomethacin to treat arthritis pain, and causes fewer stomach problems.
  • Although not without side effects, it's been around for a long time and is generally safe for short-term use.
  • Relieves moderate to severe pain. It has been shown to work as well as other opioid pain medications.
  • Compared to typical opioids, it provides unique pain relief and effects on your mood when taken regularly.
  • Has a lower chance of causing breathing problems compared to other typical opioids.
  • Doesn't cause as much constipation as other opioid pain medicines. Staying hydrated and taking laxatives can help treat this side effect.
  • It needs to be taken with food to avoid getting an upset stomach.
  • Can't be taken by pregnant women.
  • It can cause serious kidney and stomach problems (like ulcers and bleeding) the longer you take it.
  • Like all NSAIDs, it can raise your risk of having blood clots, heart attack, or stroke.
  • Some people think it's weaker than other opioid pain medications. It can also cause more upset stomach.
  • Like other opioid pain relievers, Ultram (tramadol) has a high risk of addiction, abuse, misuse, overdose, and death.
  • The extended release version of Ultram (tramadol) should only be used for severe pain that requires daily, around-the-clock treatment once alternative treatments haven't worked.
  • It's a controlled substance regulated by the federal government. This means that your use of Ultram (tramadol) will be tracked to prevent potential prescription abuse.
  • Like all opioids, don't use when pregnant, since the baby can become dependent on it and have withdrawal symptoms after birth.
Used for
Dosage forms
  • Pill
  • Delayed release tablet
  • Liquid
  • Pill
  • Extended release
  • Extended release capsule
  • Dissolving tablet
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Side effects
The Aleve (Naproxen) FDA package insert doesn’t have numbers about how common side effects are.
10possible side effects
  • Dizziness
  • Nausea
  • Constipation
  • Headache
  • Sleepiness
  • Vomiting
  • Pruritus
  • CNS Stimulation
  • Asthenia
  • Sweating
See more detailed side effects
Risks and warnings
  • Heart attack or stroke

    History of heart problems

    ...and 4 more risk factors

  • Stomach bleeding

    History of stomach bleeding or ulcers

    ...and 3 more risk factors

  • Bruising or bleeding


    ...and 3 more risk factors

  • Serious allergic reactions


    ...and 4 more risk factors

  • Lower kidney function

    Kidney disease

    ...and 4 more risk factors

  • Harm to fetus

    Women of childbearing age

See more detailed risks and warnings
  • Breathing problems

    Age 65 or greater

    ...and 2 more risk factors

  • Addiction, abuse, and overdose

    Taking more than the prescribed dose

    ...and 2 more risk factors

  • Withdrawal in newborns


  • Accidental ingestion

    Children can reach medication

See more detailed risks and warnings