Compare Naproxen vs. Tylenol

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Aleve
(naproxen)

Tylenol Regular Strength
(acetaminophen)

Relieves pain, fever, and inflammation. Aleve (Naproxen) works well for mild to moderate pain and inflammation, and it lasts longer than other NSAIDs.Relieves pain and fever. Tylenol Regular Strength (acetaminophen) effectively reduces fever and relieves pain, but it doesn't lower inflammation and swelling.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.31Naproxen
Reviews for Naproxen
78%
of people (All ages) say Naproxen is worth it
48%
say it works well
5%
say it's a big hassle
978 reviews
Have you used Aleve (naproxen)?
Worth itNot sureNot worth it
Reviews for Tylenol
77%
+1% better vs. Naproxen
37%
+11% better vs. Naproxen
3%
-2% worse vs. Naproxen
1002 reviews
Have you used Tylenol Regular Strength (acetaminophen)?
Worth itNot sureNot worth it
Side effects
NaproxenTylenol

The Naproxen FDA package insert doesn’t have numbers about how common side effects are.

More about Naproxen side effects »

The Tylenol FDA package insert doesn’t have numbers about how common side effects are.

More about Tylenol side effects »
How it works
NaproxenTylenol
Aleve (Naproxen) is a non-steroidal anti-inflammatory drug (NSAID). It blocks the inflammation process in your body, which relieves swelling and pain.Tylenol Regular Strength (acetaminophen) is an analgesic. It relieves pain and lowers fever by stopping the production of certain chemicals in the brain that cause both pain and fever.
Type of medication
NaproxenTylenol
Prescription or OTCOver-the-counter
Available as
NaproxenTylenol
  • Pill
  • Delayed release tablet
  • Liquid
  • Pill
  • Chewable tablet
  • Dissolving tablet
  • Liquid
  • Suppository
  • Injection
Used for
NaproxenTylenol
Risk factors for serious side effects
NaproxenTylenol
  • History of heart problems
  • High blood pressure
  • High cholesterol
  • Diabetes
  • Smoking
Detailed Aleve (naproxen) risks & warnings »
  • Medication administering errors
  • Injection formulation
  • Exceeding the recommended maximum daily limits
  • Drinking more than 2 alcoholic beverages a day
  • Taking with other Tylenol-containing medicines
Detailed Tylenol Regular Strength (acetaminophen) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Alcohol
NaproxenTylenol
No alcohol related info.
  • Drinking alcohol while taking Tylenol Regular Strength (acetaminophen) can damage your liver.
  • Heavy alcohol drinkers and people with liver problems should avoid using Tylenol Regular Strength (acetaminophen) since it can cause serious liver damage.
Food
NaproxenTylenol
  • Take it with a meal or a snack to prevent an upset stomach.
  • It needs to be taken with food to avoid getting an upset stomach.
No food related info.
Kidneys and liver
NaproxenTylenol
  • Aleve (Naproxen) is an NSAID that can lower kidney function or cause damage. Taking the lowest dose for the shortest amount of time lowers your risk. Your doctor should check your kidney function if you take Aleve (Naproxen) for any amount of time.
  • Can hurt your kidneys, so don't use it if you have a history of kidney problems.
  • It can cause serious kidney and stomach problems (like ulcers and bleeding) the longer you take it.
  • Taking too much acetaminophen causes liver damage that can be permanent and life-threatening. Signs of liver problems may include dark urine, feeling tired, upset stomach or stomach pain, or yellow skin or eyes. If you notice any of these symptoms, call your doctor immediately. Avoid drinking alcohol when taking Tylenol Regular Strength (acetaminophen). Avoid using Tylenol Regular Strength (acetaminophen) if you have existing liver problems since it can cause further damage.
  • Doesn't cause kidney damage and is also safe to use if you have heart problems or if you're pregnant.
  • To avoid hurting your liver, you need to keep track of the total amount of acetaminophen you are taking since it's a very common ingredient in pain and cold combination medicines.
Pain
NaproxenTylenol
  • Starts relieving pain in 30 to 60 minutes.
  • Works well to relieve pain, swelling, and fevers.
  • Works well to relieve pain and fevers.
Upsides and benefits
NaproxenTylenol
  • Works well to relieve pain, swelling, and fevers.
  • Good for menstrual cramps, toothaches, body aches, and mild arthritis pain.
  • Lasts longer than Ibuprofen, so you can take it less often.
  • Aleve (Naproxen) works as well as Aspirin and Indomethacin to treat arthritis pain, and causes fewer stomach problems.
  • Although not without side effects, it's been around for a long time and is generally safe for short-term use.
  • Works well to relieve pain and fevers.
  • Good for menstrual cramps, toothaches, body aches, and mild arthritis pain.
  • Tylenol Regular Strength (acetaminophen) causes less upset stomach, ulcers, bruising, and bleeding than other pain medications like aspirin and Advil.
  • Doesn't cause kidney damage and is also safe to use if you have heart problems or if you're pregnant.
  • Tylenol Regular Strength (acetaminophen) has been used for a long time and is generally safe for short-term use.
Downsides and risks
NaproxenTylenol
  • It needs to be taken with food to avoid getting an upset stomach.
  • Can't be taken by pregnant women.
  • It can cause serious kidney and stomach problems (like ulcers and bleeding) the longer you take it.
  • Like all NSAIDs, it can raise your risk of having blood clots, heart attack, or stroke.
  • Tylenol Regular Strength (acetaminophen) doesn't treat some kinds of pain as well as other medications like Advil.
  • Drinking alcohol while taking Tylenol Regular Strength (acetaminophen) can damage your liver.
  • To avoid hurting your liver, you need to keep track of the total amount of acetaminophen you are taking since it's a very common ingredient in pain and cold combination medicines.
  • Heavy alcohol drinkers and people with liver problems should avoid using Tylenol Regular Strength (acetaminophen) since it can cause serious liver damage.
Tips from our pharmacists for people taking the medication
NaproxenTylenol
  • Starts relieving pain in 30 to 60 minutes.
  • Take it with a meal or a snack to prevent an upset stomach.
  • Can make you bruise or bleed more easily and it can also cause stomach ulcers.
  • Don't take it with other blood thinners, like aspirin, unless your doctor tells you it's safe.
  • Can hurt your kidneys, so don't use it if you have a history of kidney problems.
  • Tylenol Regular Strength (acetaminophen) starts working within one hour.
  • Taking too much of Tylenol Regular Strength (acetaminophen) can cause liver failure and death. Don't take more than what's recommended on the package insert.
  • Acetaminophen is found in many over-the-counter and prescription products. Make sure the total amount of acetaminophen you take does not exceed 3,000 mg per day and check with your pharmacist to make sure you're not taking too much.
  • Follow age-specific dosing instructions on how much to take.
  • Let your doctor know if your symptoms don't improve in a few days.
Learn more
More about NaproxenSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Aleve (naproxen)?
Worth itNot sureNot worth it
More about TylenolSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Tylenol Regular Strength (acetaminophen)?
Worth itNot sureNot worth it