Compare Nasonex vs. Nyquil Cold and Flu

Head-to-head comparisons of medication uses, side effects, ratings, and more.


Nyquil Cold And Flu
(Acetaminophen / Dextromethorphan / Doxylamine)

Relieves allergy symptoms. Nasonex (Mometasone) is a good first-choice treatment for stuffy and runny noses caused by allergies.Relieves cold and flu symptoms, and helps you sleep. Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine) is a useful combination medicine that relieves cold and flu symptoms and will help you sleep. Make sure you really need all of its ingredients.
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Reviews & ratings
Filter group. All currently selected
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Reviews for Nasonex (Mometasone)
of people say Nasonex (Mometasone) is worth it
say it works well
say it's a big hassle
670 reviews
Reviews for Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine)
+15% vs. Nasonex (Mometasone)
+4% vs. Nasonex (Mometasone)
+2% vs. Nasonex (Mometasone)
1173 reviews
Side effects
NasonexNyquil Cold and Flu
  • Nosebleed 8%
  • Headache 4%
  • Viral infection 3%
  • Menstrual cramps 2%
  • Sinus inflammation 2%
  • Musculoskeletal pain 2%
  • Sore throat 2%
  • Coughing 1%
  • Vomiting 1%
More Nasonex side effects »

We haven’t found good data for Nyquil Cold and Flu side effects.

FDA side effect reports for Nyquil Cold and Flu »
How it works
NasonexNyquil Cold and Flu
Nasonex (Mometasone) is a topical steroid. It works directly where it's applied to help reduce swelling and inflammation in your nose.Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine) is a combination medicine that treats cold and flu symptoms. Acetaminophen relieves pain and reduces fever. Dextromethorphan is a cough suppressant. Doxylamine is an antihistamine that relieves a runny nose and makes you very sleepy.
Type of medication
NasonexNyquil Cold and Flu
Prescription only
Pain reliever
Cough suppressantAntihistamine
Ethanolamine derivative
Available as
NasonexNyquil Cold and Flu
  • Nasal spray
  • Pill
  • Liquid
Used for (click to learn more)
NasonexNyquil Cold and Flu
Risk factors for serious side effects
NasonexNyquil Cold and Flu
  • Long-term use
  • Long-term use
  • Surgery or trauma to the nose or sinuses
  • Long-term use
  • Exposure to immunizable diseases (chickenpox and measles)
  • Exposure to tuberculosis
  • Long-term use
  • Taking more than recommended dose
Detailed Nasonex (Mometasone) risks & warnings »
  • Drinking more than 2 alcoholic beverages a day
  • Taking with other Tylenol-containing medicines
  • History of liver disease
  • Using other medications that affect serotonin
  • Taking with alcohol
  • Taking with other medicines that make you less alert
  • Age 65 years or older
  • Glaucoma
  • Benign prostatic hypertrophy (BPH)
Detailed Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine) risks & warnings »
Pregnancy category
NasonexNyquil Cold and Flu
CFDA pregnancy category (Weigh risks vs. benefits)

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

See the FDA package insert
NFDA pregnancy category (Unknown)

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

See the FDA package insert
No specific alcohol-related info.
  • Avoid using alcohol and other drugs that make you drowsy.
No specific food-related info.No specific food-related info.
Kidneys and liver
No specific kidneys and liver-related info.No specific kidneys and liver-related info.
No specific sex-related info.No specific sex-related info.
No specific sleep-related info.
  • The antihistamine (doxylamine) will help you sleep.
  • Avoid using alcohol and other drugs that make you drowsy.
No specific weight-related info.No specific weight-related info.
Upsides and benefits
NasonexNyquil Cold and Flu
  • First-choice medication for treating runny and stuffy noses caused by allergies. It works by reducing inflammation in the nose.
  • Because it's used directly where the inflammation is happening, it has fewer side effects than oral steroids do and has a lower chance of causing withdrawal symptoms once the medication is stopped.
  • Can be used as needed to help control symptoms in people age 13 years or older.
  • Available as a generic, which is cheaper.
  • Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have watery eyes, a cough, fever, and pain.
  • The cough medicine (dextromethorphan) works well and has very few side effects.
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than other pain medications like aspirin or ibuprofen.
  • The antihistamine (doxylamine) will help you sleep.
Downsides and risks
NasonexNyquil Cold and Flu
  • Needs to be primed 10 times before it can be used, or re-primed if not used for more than 2 weeks.
  • Doesn't have a counter on it, so it can be hard to remember how many sprays are left (each bottle has 120 sprays).
  • Since the medicine in Nasonex (Mometasone) is a steroid, it can slow down your healing process if you've hurt your nose or had nose surgery.
  • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
  • You shouldn't use it if you have high blood pressure.
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
Tips from our pharmacists for people taking the medication
NasonexNyquil Cold and Flu
  • Use Nasonex (Mometasone) once a day, following age-specific recommendations on how many sprays to use. Don't take more than prescribed.
  • Blow your nose before using.
  • Can cause thrush (a fungal infection) inside your nose and throat. Can also cause nosebleeds, a sore throat, and headaches.
  • Needs to be used regularly during allergy season for it to work. It can take 1 to 2 weeks for the medicine to start working fully.
  • Check with your doctor or pharmacist on how to use the nasal spray the right way.
  • Shake well before using it. Before the first use, prime the bottle by spraying it until you see a fine mist.
  • Doxylamine (the antihistamine ingredient) can make you tired, so take it close to bedtime.
  • Follow age-specific dosing instructions on how much to take. Don't take more than recommended on the package.
  • Contains acetaminophen, also known as Tylenol or APAP. Taking too much can cause liver failure and death. Don't take more than what's recommended on the package or with other Tylenol-containing products.
  • Avoid using alcohol and other drugs that make you drowsy.
  • Let your doctor know if your symptoms don't improve in a few days, or if you have a really bad sore throat with a fever, headache, nausea, or vomiting.
Learn more
More about NasonexSide effectsReviews & ratingsAlternativesFDA package insert
More about Nyquil Cold and FluSide effectsReviews & ratingsAlternativesFDA package insert