Compare nefazodone vs. Zoloft

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Serzone
(nefazodone)

Zoloft
(sertraline)

Treats depression. Serzone (nefazodone) is usually used with other medicines to treat depression, but it is more likely to cause liver damage.Improves mood and helps you relax. Zoloft (Sertraline) is good for treating depression and anxiety. It's more likely to cause insomnia and diarrhea than other antidepressants.
Reviews & ratings
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Have you used Serzone (nefazodone)?
Worth itNot sureNot worth it
Reviews for Zoloft
59%
-59% worse vs. nefazodone
41%
-41% worse vs. nefazodone
15%
+15% better vs. nefazodone
1472 reviews
Have you used Zoloft (sertraline)?
Worth itNot sureNot worth it
Side effects
nefazodoneZoloft
  • Headache 3%
  • Sleepiness 11%
  • Dry mouth 12%
  • Nausea 10%
  • Dizziness 12%
  • Constipation 6%
  • Weakness 6%
  • Trouble sleeping 2%
  • Lightheadedness 7%
  • Indigestion 2%
More nefazodone side effects »
  • Nausea 14%
  • Diarrhea/Loose Stools 9%
  • Insomnia 7%
  • Mouth Dry 7%
  • Somnolence 7%
  • Dizziness 5%
  • Tremor 8%
  • Fatigue 3%
  • Sweating Increased 5%
  • Constipation 2%
More Zoloft side effects »
How it works
nefazodoneZoloft
Serzone (nefazodone) is a serotonin reuptake inhibitor. Serzone (nefazodone) raises the amount of serotonin in the brain, which helps to regulate your mood.Zoloft (Sertraline) is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It increases the activity of serotonin in the brain, which regulates mood.
Type of medication
nefazodoneZoloft
Prescription onlyPrescription only
Available as
nefazodoneZoloft
  • Pill
  • Pill
  • Liquid
Used for
nefazodoneZoloft
Risk factors for serious side effects
nefazodoneZoloft
  • People under age 24
  • Taking medicine for high blood pressure
  • History of seizures
  • History of heart attack or heart disease
  • Medicines that slow the heartbeat
Detailed Serzone (nefazodone) risks & warnings »
  • Under 24 years old
  • Interactions with other medications
  • Stopping Zoloft (Sertraline) suddenly
  • Taking with blood-thinning drugs
  • Elderly
Detailed Zoloft (sertraline) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Interactions
nefazodoneZoloft
  • Compared to other similar medicines, Serzone (nefazodone) has a lot of interactions with other drugs, so your doctor might have to adjust the doses of your other medicines.
  • It interacts with St. John's Wort and Tryptophan.
Pain
nefazodoneZoloft
  • Talk to your doctor right away if you notice yellowing in the whites of your eyes or your skin, a high fever, pain in your stomach, or dark urine.
No pain related info.
Sex
nefazodoneZoloft
No sex related info.
  • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
Sleep
nefazodoneZoloft
No sleep related info.
  • Zoloft (Sertraline) may increase the risk of low sodium levels in the blood (hyponatremia). Watch out for symptoms including headache, difficulty concentrating, memory problems, confusion, weakness, and unsteadiness, which may lead to falls. Talk to a doctor right away before developing more serious symptoms, such as hallucination, fainting, coma, and death.
  • Causes less drowsiness than other antidepressants.
Upsides and benefits
nefazodoneZoloft
  • Serzone (nefazodone) is a good choice to take with other medicines for depression if they haven't worked by themselves.
  • Serzone (nefazodone) is available in generic.
  • Effective at lowering symptoms and relapse rates of depression and anxiety disorders.
  • Causes less drowsiness than other antidepressants.
  • Six out of ten people who use an antidepressant for the first time find that it works for them.
Downsides and risks
nefazodoneZoloft
  • While Serzone (nefazodone) is available as a generic, it's not considered a first or second choice medicine for depression because it is more likely to cause liver damage than other similar medicines.
  • Serzone (nefazodone) is usually taken 2 times a day; the first choice medicines are only taken 1 time a day.
  • It can take up to 3 months before you notice the full effects of Serzone (nefazodone).
  • Compared to other similar medicines, Serzone (nefazodone) has a lot of interactions with other drugs, so your doctor might have to adjust the doses of your other medicines.
  • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
  • More likely to cause diarrhea than other antidepressants.
  • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than 24.
  • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
Tips from our pharmacists for people taking the medication
nefazodoneZoloft
  • You may not notice any changes in your mood until you've taken Serzone (nefazodone) for at least 2 weeks. The full effects may not happen for at least 2 to 3 months.
  • Don't drive or do anything requiring concentration until you know how Serzone (nefazodone) affects you because it can make you feel dizzy.
  • If you forget a dose of Serzone (nefazodone), take it as soon as you remember. If it's time for your next dose, don't take 2 doses at the same time to make up for the missed dose.
  • Store Serzone (nefazodone) in your pantry away from heat, light, and moisture.
  • Talk to your doctor right away if you notice yellowing in the whites of your eyes or your skin, a high fever, pain in your stomach, or dark urine.
  • Takes about 8 to 12 weeks to see the medication's full effects on your mood.
  • It interacts with St. John's Wort and Tryptophan.
  • Stop taking it slowly to avoid getting withdrawal symptoms.
  • Tell your doctor if you notice sudden mood changes or unusual thoughts.
Learn more
More about nefazodoneSide effectsAlternativesFDA package insert
Have you used Serzone (nefazodone)?
Worth itNot sureNot worth it
More about ZoloftSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Zoloft (sertraline)?
Worth itNot sureNot worth it