Compare Nesina vs. Actos

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Nesina (Alogliptin)

Actos (pioglitazone)

Prescription only
Lowers your blood sugar.

alogliptin is a good add-on treatment if your blood sugar is still too high, but you don't want to use an injectable medicine.

Lowers blood sugar.

Actos (pioglitazone) can improve blood sugar control but is not a top choice since it has a lot of side effects.

4.1/ 7 average rating with 175 reviewsforActos
Upsides
  • Oral blood sugar-lowering medicine.
  • Lowers A1c levels by around 1%. (Hemoglobin A1c measures your average blood sugar over time.)
  • Prevents the harmful effects of high sugar levels on your organs and blood vessels.
  • Rarely causes low blood sugar.
  • Patients taking alogliptin had less cold symptoms than patients taking Januvia.
  • Improves sugar control and lowers A1c levels by around 1%.
  • Easily taken by mouth as a once a day pill.
  • Prevents the harmful effects of high sugar levels on your organs.
  • Rarely causes low blood sugar.
  • Lower the risk of heart attack or stroke.
Downsides
  • Not as strong as other diabetes medicines. Your doctor might add it to your blood sugar-lowering regimen if your sugar levels are still too high.
  • Likely expensive since there's no generic version available.
  • Some people might get frequent throat infections or nasal congestion.
  • May take several weeks to lower blood sugar.
  • Can cause weight gain.
  • People with heart failure or history of bladder cancer shouldn't use this medicine.
  • Some people might get fluid accumulation (edema), from minor ankle swelling to fluid in lungs that makes it hard to breathe.
  • Raises the risk of bone fractures, especially for people who already have a risk for fractures.
Used for
  • Diabetes mellitus type 2
Dosage forms
  • Pill
  • Pill
Price
Lowest price near you
$94.57
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Lowest price near you
$12.05
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Reviews
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175 
42%
think this treatment is worth it
30%
think this treatment works well
21%
think this treatment is a hassle

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Side effects
The Nesina (Alogliptin) FDA package insert doesn’t have numbers about how common side effects are.
10possible side effects
  • Low blood sugar
    27%
  • Swelling
    27%
  • Colds and flu
    13%
  • Headache
    9%
  • Heart failure
    8%
  • Sinus infection
    6%
  • Back pain
    6%
  • Pain in arms and legs
    6%
  • Muscle pain
    5%
  • Sore throat
    5%
See more detailed side effects
Risks and warnings
See more detailed risks and warnings
  • Heart failure

    Heart failure

  • Liver damage

    Current liver problems

  • Bladder cancer

    History of bladder cancer

  • Bone fracture

    Women

See more detailed risks and warnings