Compare Nesina vs. Actos

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Nesina
(alogliptin)

Actos
(pioglitazone)

Lowers your blood sugar. alogliptin is a good add-on treatment if your blood sugar is still too high, but you don't want to use an injectable medicine.Lowers blood sugar. Actos (Pioglitazone) is a last-choice blood sugar-lowering medicine since it's only moderately effective but has a lot of undesirable side effects.
Reviews & ratings
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Have you used Nesina (alogliptin)?
Worth itNot sureNot worth it
Reviews for Actos
42%
+58% better vs. Nesina
30%
+70% better vs. Nesina
21%
+21% better vs. Nesina
175 reviews
Have you used Actos (pioglitazone)?
Worth itNot sureNot worth it
Side effects
NesinaActos

We haven’t found good data for Nesina side effects.

FDA side effect reports for Nesina »
  • Swelling due to excess fluid 11%
  • Low blood sugar 8%
  • Ear, nose, or throat infection 4%
  • Headache 2%
  • Cardiac failure 2%
  • Back pain 1%
  • Sinus inflammation 1%
  • Muscle pain 2%
More Actos side effects »
How it works
NesinaActos
alogliptin is an anti-diabetic drug. It improves your body's ability to use insulin to lower your blood sugar.Actos (Pioglitazone) is an anti-diabetic drug. It improves your body's ability to use insulin to lower your blood sugar.
Type of medication
NesinaActos
Prescription only
Available as
NesinaActos
  • Pill
  • Pill
Used for
NesinaActos
  • Diabetes Mellitus Type 2
Risk factors for serious side effects
NesinaActos
    Detailed Nesina (alogliptin) risks & warnings »
    • Heart failure diagnosis
    • Current liver problems
    • Female
    Detailed Actos (pioglitazone) risks & warnings »
    Pregnancy

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Weight
    NesinaActos
    No weight related info.
    • Can cause weight gain, headache, and fluid retention.
    • More likely to cause weight gain (2 to 6 pounds or more) compared to other blood sugar-lowering medicines.
    Upsides and benefits
    NesinaActos
    • Oral blood sugar-lowering medicine.
    • Lowers A1c levels by around 1%. (Hemoglobin A1c measures your average blood sugar over time.)
    • Prevents the harmful effects of high sugar levels on your organs and blood vessels.
    • Rarely causes low blood sugar.
    • Patients taking alogliptin had less cold symptoms than patients taking Januvia.
    • Oral blood sugar-lowering medicine.
    • Lowers A1c levels by around 1%. (Hemoglobin A1c measures your average blood sugar over time.)
    • Prevents the harmful effects of high sugar levels on your organs and blood vessels.
    • Rarely causes low blood sugar.
    Downsides and risks
    NesinaActos
    • Not as strong as other diabetes medicines. Your doctor might add it to your blood sugar-lowering regimen if your sugar levels are still too high.
    • Likely expensive since there's no generic version available.
    • Some people might get frequent throat infections or nasal congestion.
    • May take several weeks to lower blood sugar.
    • You have to check your blood sugar regularly with this medicine.
    • Has more side effects than similar medicines, so it's usually not the first choice for new Type 2 diabetes patients.
    • More likely to cause weight gain (2 to 6 pounds or more) compared to other blood sugar-lowering medicines.
    • Up to 1 in 10 people might get fluid retention (edema), ranging from mild ankle swelling to severe swelling in the lungs that makes it hard to breathe. People with severe congestive heart failure shouldn't use Actos.
    • Raises the risk of bone fractures, especially for people who already have a risk for fractures.
    • Slightly raises the risk of bladder cancer.
    Tips from our pharmacists for people taking the medication
    NesinaActos
    • Can cause headache and cold-like symptoms.
    • Tell your doctor about any mental confusion, persistent abdominal pain, dark urine, yellowing of eyes/skin, or easy bruising.
    • Can be expensive depending on insurance coverage.
    • Check your blood sugar regularly.
    • Takes several weeks to see full effect on blood sugar control.
    • Can cause weight gain, headache, and fluid retention.
    • Tell your doctor about any mental confusion, persistent abdominal pain, dark urine, yellowing of eyes/skin, or easy bruising.
    • Not recommended for patients with certain heart problems.
    • Check your blood sugar regularly.
    Learn more
    More about NesinaSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Nesina (alogliptin)?
    Worth itNot sureNot worth it
    More about ActosSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Actos (pioglitazone)?
    Worth itNot sureNot worth it