Compare Nesina vs. glyburide

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Nesina
(alogliptin)

Diabeta
(glyburide)

Lowers your blood sugar. alogliptin is a good add-on treatment if your blood sugar is still too high, but you don't want to use an injectable medicine.Lowers blood sugar. Diabeta (glyburide) is a good oral anti-diabetic medicine, but can cause hypoglycemia or low blood sugar.
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Coupons for Nesina
Best available price for 30 (25mg) tablets of alogliptin
Coupons for glyburide
Best available price for 60 (5mg) tablets of glyburide
Reviews & ratings
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Have you used Nesina (alogliptin)?
Worth itNot sureNot worth it
Reviews for glyburide
45%
+55% better vs. Nesina
34%
+66% better vs. Nesina
21%
+21% better vs. Nesina
110 reviews
Have you used Diabeta (glyburide)?
Worth itNot sureNot worth it
Side effects
Nesinaglyburide

We haven’t found good data for Nesina side effects.

FDA side effect reports for Nesina »
  • Nausea and heartburn 2%
  • Skin allergies 2%
More glyburide side effects »
How it works
Nesinaglyburide
alogliptin is an anti-diabetic drug. It improves your body's ability to use insulin to lower your blood sugar.Diabeta (glyburide) stimulates your body to release insulin and lower blood sugar.
Type of medication
Nesinaglyburide
Prescription only
Available as
Nesinaglyburide
  • Pill
  • Pill
Used for
Nesinaglyburide
  • Diabetes Mellitus Type 2
Risk factors for serious side effects
Nesinaglyburide
    Detailed Nesina (alogliptin) risks & warnings »
    • Over age 65
    • Kidney problems
    • Use of other blood sugar lowering medicines
    • Alcohol
    • Intense physical activity
    Detailed Diabeta (glyburide) risks & warnings »
    Pregnancy

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Alcohol
    Nesinaglyburide
    No alcohol related info.
    • Try to avoid drinking alcohol while on Diabeta (glyburide).
    Food
    Nesinaglyburide
    No food related info.
    • Eat well-balanced meals to avoid low blood sugar.
    Kidneys and liver
    Nesinaglyburide
    No kidneys and liver related info.
    • Not ideal for elderly or those with poor kidney function.
    Weight
    Nesinaglyburide
    No weight related info.
    • Can cause weight gain, dizziness, or stomach upset.
    • Can cause weight gain (about 2 to 3 pounds).
    Upsides and benefits
    Nesinaglyburide
    • Oral blood sugar-lowering medicine.
    • Lowers A1c levels by around 1%. (Hemoglobin A1c measures your average blood sugar over time.)
    • Prevents the harmful effects of high sugar levels on your organs and blood vessels.
    • Rarely causes low blood sugar.
    • Patients taking alogliptin had less cold symptoms than patients taking Januvia.
    • Available as an oral tablet.
    • Lowers your A1c (average blood sugar over time) up to 2%.
    • Available in generic version.
    • Available in single pill combination with other anti-diabetic medicines.
    Downsides and risks
    Nesinaglyburide
    • Not as strong as other diabetes medicines. Your doctor might add it to your blood sugar-lowering regimen if your sugar levels are still too high.
    • Likely expensive since there's no generic version available.
    • Some people might get frequent throat infections or nasal congestion.
    • More likely to cause hypoglycemia or low blood sugar than other types of oral anti-diabetics.
    • You will have to check your blood sugar often when you first start taking it.
    • Can cause weight gain (about 2 to 3 pounds).
    • Not ideal for elderly or those with poor kidney function.
    • May not work as well for those with severe diabetes and when pancreas cannot produce insulin.
    Tips from our pharmacists for people taking the medication
    Nesinaglyburide
    • Can cause headache and cold-like symptoms.
    • Tell your doctor about any mental confusion, persistent abdominal pain, dark urine, yellowing of eyes/skin, or easy bruising.
    • Can be expensive depending on insurance coverage.
    • Check your blood sugar regularly.
    • Check your blood sugar regularly.
    • Eat well-balanced meals to avoid low blood sugar.
    • Works best if you take it 30 minutes before first main meal of the day.
    • Can cause weight gain, dizziness, or stomach upset.
    • Try to avoid drinking alcohol while on Diabeta (glyburide).
    Learn more
    More about NesinaSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Nesina (alogliptin)?
    Worth itNot sureNot worth it
    More about glyburideSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Diabeta (glyburide)?
    Worth itNot sureNot worth it