Compare Nesina vs. Metformin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Nesina
(Alogliptin)

Glucophage
(Metformin)

Lowers your blood sugar. alogliptin is a good add-on treatment if your blood sugar is still too high, but you don't want to use an injectable medicine.Lowers blood sugar. Glucophage (Metformin) is a very effective medicine to lower blood sugar and the risk of complications and death from diabetes, but it's likely to cause diarrhea for the first few weeks.
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Reviews & ratings
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Have you used Nesina (Alogliptin)?
Worth itNot sureNot worth it
Reviews for Glucophage (Metformin)
65%
-35% worse vs. Nesina (Alogliptin)
46%
-54% worse vs. Nesina (Alogliptin)
16%
-16% worse vs. Nesina (Alogliptin)
938 reviews
Have you used Glucophage (Metformin)?
Worth itNot sureNot worth it
Side effects
NesinaMetformin

We haven’t found good data for Nesina side effects.

FDA side effect reports for Nesina »
  • Diarrhea 41%
  • Nausea/vomiting 18%
  • Passing gas 6%
  • Muscle weakness 3%
  • Indigestion 3%
  • Abdominal discomfort 1%
  • Headache 1%
More Metformin side effects »
How it works
NesinaMetformin
alogliptin is an anti-diabetic drug. It improves your body's ability to use insulin to lower your blood sugar.Glucophage (Metformin) is an anti-diabetic drug. It lowers sugar production in your body, decreases sugar absorption in your intestines, and makes your body more sensitive to insulin.
Type of medication
NesinaMetformin
Prescription only
Available as
NesinaMetformin
  • Pill
  • Pill
  • Extended release
  • Liquid
Used for
NesinaMetformin
  • Diabetes Mellitus Type 2
Risk factors for serious side effects
NesinaMetformin
      Detailed Nesina (Alogliptin) risks & warnings »
      • Kidney problems
      • Liver problems
      • Congestive heart failure
      • Using contrast dye for procedures
      • Surgery
      • Alcohol use
        Detailed Glucophage (Metformin) risks & warnings »
        Pregnancy

        Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

        Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

        Food
        NesinaMetformin
        No food related info.
        • Always take it with food or switch to the extended release version to avoid upset stomach.
        Kidneys and liver
        NesinaMetformin
        No kidneys and liver related info.
        • People with poor kidney function can't use it.
        • Glucophage (Metformin) can cause this rare but life-threatening condition. Symptoms include deep and rapid breathing, nausea, vomiting, and stomach pain. This is a medical emergency and you should get help right away. Baseline blood work for kidney and liver function are helpful to see if you can use Glucophage (Metformin). It may not be a good choice for people with kidney problems. Glucophage (Metformin) should be stopped 48 hours before and/or after surgery or any imaging procedure needing contrast dye.
        Weight
        NesinaMetformin
        No weight related info.
        • Unlike some diabetes medicines, doesn't cause weight gain or low blood sugar.
        Upsides and benefits
        NesinaMetformin
        • Oral blood sugar-lowering medicine.
        • Lowers A1c levels by around 1%. (Hemoglobin A1c measures your average blood sugar over time.)
        • Prevents the harmful effects of high sugar levels on your organs and blood vessels.
        • Rarely causes low blood sugar.
        • Patients taking alogliptin had less cold symptoms than patients taking Januvia.
        • Oral blood sugar-lowering medicine.
        • A common first treatment for people with newly-diagnosed Type 2 diabetes.
        • The only oral diabetes medicine that lowers complications and deaths from conditions related to diabetes.
        • Lowers A1c levels by 1-2%. (Hemoglobin A1c measures your average blood sugar over time.)
        • Prevents the harmful effects of high sugar levels on your organs and blood vessels.
        • Also lowers certain lipid (fat and cholesterol) levels.
        • Unlike some diabetes medicines, doesn't cause weight gain or low blood sugar.
        • You don't have to check your blood sugar every day with this medicine.
        • One of the least expensive diabetes medicines.
        Downsides and risks
        NesinaMetformin
        • Not as strong as other diabetes medicines. Your doctor might add it to your blood sugar-lowering regimen if your sugar levels are still too high.
        • Likely expensive since there's no generic version available.
        • Some people might get frequent throat infections or nasal congestion.
        • Most people will have nausea, indigestion, or diarrhea in the first few weeks. You can minimize this if you take it on a full stomach.
        • People with poor kidney function can't use it.
        • Only works if your body can still make your own insulin, a hormone that tells your body what to do with sugar, protein, and fat.
        Tips from our pharmacists for people taking the medication
        NesinaMetformin
        • Can cause headache and cold-like symptoms.
        • Tell your doctor about any mental confusion, persistent abdominal pain, dark urine, yellowing of eyes/skin, or easy bruising.
        • Can be expensive depending on insurance coverage.
        • Check your blood sugar regularly.
        • Can cause upset stomach with nausea and especially diarrhea in the first couple of weeks.
        • Always take it with food or switch to the extended release version to avoid upset stomach.
        • Tell your doctor about any deep or rapid breathing, or persistent nausea, vomiting, and stomach pain.
        • Check your blood sugar regularly.
        Learn more
        More about NesinaSide effectsReviews & ratingsAlternativesFDA package insert
        Have you used Nesina (Alogliptin)?
        Worth itNot sureNot worth it
        More about MetforminSide effectsReviews & ratingsAlternativesFDA package insert
        Have you used Glucophage (Metformin)?
        Worth itNot sureNot worth it