Compare Nesina vs. metformin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Nesina
(alogliptin)

Glucophage
(metformin)

Lowers your blood sugar. alogliptin is a good add-on treatment if your blood sugar is still too high, but you don't want to use an injectable medicine.Lowers blood sugar. Glucophage (metformin) is the first choice medicine to control your blood sugar and lower the risk of death from diabetes, although a few people may not tolerate the stomach side effects.
Reviews & ratings
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Have you used Nesina (alogliptin)?
Worth itNot sureNot worth it
Reviews for metformin
65%
+35% better vs. Nesina
46%
+54% better vs. Nesina
16%
+16% better vs. Nesina
938 reviews
Have you used Glucophage (metformin)?
Worth itNot sureNot worth it
Side effects
Nesinametformin

We haven’t found good data for Nesina side effects.

FDA side effect reports for Nesina »
  • Diarrhea 41%
  • Nausea/vomiting 18%
  • Gas 6%
  • Weakness 3%
  • Indigestion 3%
  • Stomach pain 1%
  • Headache 1%
More metformin side effects »
How it works
Nesinametformin
alogliptin is an anti-diabetic drug. It improves your body's ability to use insulin to lower your blood sugar.Glucophage (metformin) is an anti-diabetic drug. It lowers the amount of sugar your body makes or absorbs, and allows your body use the existing insulin better.
Type of medication
Nesinametformin
Prescription only
Available as
Nesinametformin
  • Pill
  • Pill
  • Extended release pill
  • Liquid
Used for
Nesinametformin
  • Diabetes Mellitus Type 2
Risk factors for serious side effects
Nesinametformin
    Detailed Nesina (alogliptin) risks & warnings »
    • Kidney problems
    • Liver problems
    • Congestive heart failure
    • Using contrast dye for procedures
    • Surgery
    Detailed Glucophage (metformin) risks & warnings »
    Pregnancy

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    Alcohol
    Nesinametformin
    No alcohol related info.
    • Limit or avoid alcohol when taking this medicine.
    • Excessive or chronic alcohol use can increase the risk of a dangerous side effect.
    Food
    Nesinametformin
    No food related info.
    • Always take it with food to lessen stomach upset.
    Kidneys and liver
    Nesinametformin
    No kidneys and liver related info.
    • Glucophage (metformin) can cause this rare life-threatening condition. Your doctor will check your kidneys and liver before you start. Symptoms include deep and rapid breathing, nausea, vomiting, and stomach pain. This is a medical emergency and you should get help right away. You're more likely to get this if you already have kidney problems. Glucophage (metformin) should be stopped 48 hours before and after surgery or any imaging procedure needing contrast dye.
    • Usually not a good choice for people with kidney problems. Your doctor will tell you if Glucophage (metformin) is right for you to take.
    Weight
    Nesinametformin
    No weight related info.
    • Doesn't cause weight gain.
    Upsides and benefits
    Nesinametformin
    • Oral blood sugar-lowering medicine.
    • Lowers A1c levels by around 1%. (Hemoglobin A1c measures your average blood sugar over time.)
    • Prevents the harmful effects of high sugar levels on your organs and blood vessels.
    • Rarely causes low blood sugar.
    • Patients taking alogliptin had less cold symptoms than patients taking Januvia.
    • Improves sugar control and lowers A1c levels as much as 2%.
    • One of the few diabetes medicines that lowers the risk of death from diabetes-related complications.
    • Doesn't cause weight gain.
    • Rarely causes low blood sugar.
    Downsides and risks
    Nesinametformin
    • Not as strong as other diabetes medicines. Your doctor might add it to your blood sugar-lowering regimen if your sugar levels are still too high.
    • Likely expensive since there's no generic version available.
    • Some people might get frequent throat infections or nasal congestion.
    • Often causes stomach upset, like diarrhea, nausea, gas, or stomach cramping.
    • Usually not a good choice for people with kidney problems. Your doctor will tell you if Glucophage (metformin) is right for you to take.
    • Excessive or chronic alcohol use can increase the risk of a dangerous side effect.
    Tips from our pharmacists for people taking the medication
    Nesinametformin
    • Can cause headache and cold-like symptoms.
    • Tell your doctor about any mental confusion, persistent abdominal pain, dark urine, yellowing of eyes/skin, or easy bruising.
    • Can be expensive depending on insurance coverage.
    • Check your blood sugar regularly.
    • Can cause upset stomach with nausea and especially diarrhea in the first couple of weeks.
    • Always take it with food to lessen stomach upset.
    • Stay hydrated.
    • Limit or avoid alcohol when taking this medicine.
    • Tell your doctor about any deep or rapid breathing, or persistent nausea, vomiting, and stomach pain.
    • Check your blood sugar regularly.
    Learn more
    More about NesinaSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Nesina (alogliptin)?
    Worth itNot sureNot worth it
    More about metforminSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Glucophage (metformin)?
    Worth itNot sureNot worth it