Compare Neurontin vs. Depakote

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Neurontin
(Gabapentin)

Depacon
(Valproate, Valproic Acid, Or Divalproex)

Treats tingling and burning nerve pain. Neurontin (Gabapentin) is an old seizure disorder medicine that's now used to treat nerve-related pain caused by different conditions.Prevents seizures and stabilizes mood. Depacon (Valproate, Valproic Acid, Or Divalproex) is good long-term prevention for epilepsy, bipolar disorder, and migraines, but can cause weight gain.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
4.542087542087542Neurontin
Reviews for Neurontin (Gabapentin)
57%
of people say Neurontin (Gabapentin) is worth it
39%
say it works well
19%
say it's a big hassle
Reviews for Depacon (Valproate, Valproic Acid, Or Divalproex)
46%
11% vs. Neurontin (Gabapentin)
39%
Same vs. Neurontin (Gabapentin)
27%
8% vs. Neurontin (Gabapentin)
Side effects
NeurontinDepakote
  • Dizziness 21%
  • Drowsiness 16%
  • Lack of muscle coordination 7%
  • Leg or ankle swelling 6%
  • Fatigue 6%
  • Hostility 5%
  • Involuntary eye movement 4%
  • Double vision 4%
  • Tremor 4%
  • Dry mouth 4%
More Neurontin side effects »
  • Nausea 34%
  • Muscle weakness 20%
  • Vomiting 20%
  • Abdominal pain 17%
  • Dizziness 12%
  • Headache 10%
  • Double vision 7%
  • Involuntary eye movement 7%
  • Lack of muscle coordination 7%
  • Accidental injury 6%
More Depakote side effects »
How it works
NeurontinDepakote
Neurontin (Gabapentin) is an antiepileptic and nerve pain reliever. Researchers don't know exactly how it works, but it has a similar structure to GABA, a neurotransmitter that calms nerves in the brain and spinal cord.Depacon (Valproate, Valproic Acid, Or Divalproex) is an antiepileptic. Researchers don't know exactly how it works. It seems to increase the amount of GABA, a chemical that calms nerves in the brain.
Type of medication
NeurontinDepakote
Anticonvulsant
GABA analog
Prescription only
AnticonvulsantPrescription only
Available as
NeurontinDepakote
  • Pill
  • Oral solution
  • Pill
  • Extended release
  • Extended release capsule
  • Sprinkle
  • Liquid
Used for (click to learn more)
NeurontinDepakote
Risk factors for serious side effects
NeurontinDepakote
    • Children ages 3 to 12
      • Taking with alcohol or drugs
      • Stopping Neurontin (Gabapentin) suddenly
      Detailed Neurontin (Gabapentin) risks & warnings »
        • Children under age 2
        • History of metabolic disorders
          • History of depression
            • History of metabolic disorders
            • People also taking Topamax
            • People also taking Topamax
              • Stopping Depacon (Valproate, Valproic Acid, Or Divalproex) suddenly
              Detailed Depacon (Valproate, Valproic Acid, Or Divalproex) risks & warnings »
              Pregnancy category
              NeurontinDepakote
              CFDA pregnancy category (Weigh risks vs. benefits)

              Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

              See the FDA package insert
              DFDA pregnancy category (Weigh risks vs. benefits)

              Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

              See the FDA package insert
              Alcohol
              • You can't skip or miss doses since suddenly stopping Neurontin (Gabapentin) can cause seizures. This is even more likely if you drink alcohol, so it might not be the best medication for heavy drinkers.
              No specific alcohol-related info.
              Food
              • Take the extended-release tablet with food.
              • Take with food to avoid upset stomach.
              Kidneys and liver
              No specific kidneys and liver-related info.No specific kidneys and liver-related info.
              Sex
              No specific sex-related info.No specific sex-related info.
              Sleep
              • Neurontin (Gabapentin) is likely to cause some side effects, including memory problems, drowsiness, dizziness, or confusion.
              No specific sleep-related info.
              Weight
              No specific weight-related info.
              • Can cause upset stomach, hair loss, weight gain, sleepiness, and tremor.
              • May cause hair loss and weight gain.
              Upsides and benefits
              NeurontinDepakote
              • Originally used to treat epilepsy (partial seizures), but now it primarily treats neuropathic pain that's caused by nerve stimulation or damage.
              • Studies show it's most effective for nerve pain from diabetes, shingles, and fibromyalgia (a painful muscle condition).
              • It's available as a generic, so it's less expensive than similar medications.
              • Lowers the frequency of seizures, especially for people with absence, tonic-clonic, and complex partial seizures.
              • One of the first-line options to stabilize mood for people with bipolar disorder.
              • Helpful in preventing frequent migraine headaches.
              Downsides and risks
              NeurontinDepakote
              • Neurontin (Gabapentin) is likely to cause some side effects, including memory problems, drowsiness, dizziness, or confusion.
              • You can't skip or miss doses since suddenly stopping Neurontin (Gabapentin) can cause seizures. This is even more likely if you drink alcohol, so it might not be the best medication for heavy drinkers.
              • Can cause upset stomach, hair loss, weight gain, sleepiness, and tremor.
              • Can cause liver damage, so it's probably not safe if you already have liver problems.
              • Not safe to use if you're pregnant.
              • Requires routine blood tests to see how the medicine is affecting your body.
              Tips from our pharmacists for people taking the medication
              NeurontinDepakote
              • Side effects are common, but usually manageable.
              • Don't drive while taking Neurontin (Gabapentin) until you know how the medication affects you.
              • Neurontin and generic forms of Gabapentin have the same ingredients as Gralise and Horizant, but are dosed differently. Make sure you know which form you're taking since they are used for different purposes.
              • Take the extended-release tablet with food.
              • Stop taking Neurontin (Gabapentin) slowly over at least one week to avoid getting withdrawal symptoms.
              • For the first week, avoid activities that require you to be alert.
              • Don't use if pregnant.
              • Requires routine blood tests.
              • Take with food to avoid upset stomach.
              • May cause hair loss and weight gain.
              • Different versions of Depakote have different dosing. Be careful.
              • Report confusion, persistent abdominal pain, yellowing of eyes/skin, or easy bruising to your doctor.
              • Takes 3 to 4 weeks to feel full effects on mood.
              Learn more
              More about NeurontinSide effectsReviews & ratingsAlternativesFDA package insert
              More about DepakoteSide effectsReviews & ratingsAlternativesFDA package insert