Compare Neurontin vs. Horizant

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Neurontin
(gabapentin)

Horizant
(gabapentin enacarbil)

Treats tingling and burning nerve pain. Neurontin (Gabapentin) is an old seizure disorder medicine that's now used to treat nerve-related pain caused by different conditions.Calms leg movements and nerve pain. Horizant (Gabapentin Enacarbil) is a good way to treat pain since it can be used with other pain medications and it's not addictive. You'll need to stop drinking alcohol and it can be somewhat expensive.
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Coupons for Neurontin
Best available price for 90 (300mg) capsules of gabapentin
Coupons for Horizant
Best available price for 30 (600mg) tablets of horizant
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.56Neurontin
Reviews for Neurontin
57%
of people (All ages) say Neurontin is worth it
40%
say it works well
19%
say it's a big hassle
620 reviews
Have you used Neurontin (gabapentin)?
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Have you used Horizant (gabapentin enacarbil)?
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Side effects
NeurontinHorizant
  • Dizziness 21%
  • Drowsiness 16%
  • Leg or ankle swelling 6%
  • Muscle weakness 1%
  • Diarrhea 2%
  • Infection 2%
  • Dry mouth 3%
  • Constipation 2%
  • Accidental injury 2%
  • Vomiting 2%
More Neurontin side effects »
  • Somnolence/sedation 14%
  • Dizziness 9%
  • Headache 1%
  • Nausea 1%
  • Fatigue 2%
  • Irritability 3%
  • Dry mouth 1%
  • Passing gas 3%
  • Increased appetite 2%
More Horizant side effects »
How it works
NeurontinHorizant
Neurontin (Gabapentin) is an antiepileptic and nerve pain reliever. Researchers don't know exactly how it works, but it has a similar structure to GABA, a neurotransmitter that calms nerves in the brain and spinal cord.Horizant (Gabapentin Enacarbil) treats restless leg syndrome and pain caused by shingles by lowering your body's response to pain. It's used for long-lasting (chronic) pain and doesn't work for sudden (acute) pain.
Type of medication
NeurontinHorizant
Prescription onlyPrescription only
Available as
NeurontinHorizant
  • Pill
  • Oral solution
  • Pill
Used for
NeurontinHorizant
Risk factors for serious side effects
NeurontinHorizant
  • Children ages 3 to 12
  • Taking with alcohol or drugs
  • Stopping Neurontin (Gabapentin) suddenly
Detailed Neurontin (gabapentin) risks & warnings »
  • Stopping Horizant (Gabapentin Enacarbil) suddenly
Detailed Horizant (gabapentin enacarbil) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Alcohol
NeurontinHorizant
No alcohol related info.
  • Need to avoid alcohol while on Horizant (Gabapentin Enacarbil).
Food
NeurontinHorizant
  • Take the extended-release tablet with food.
  • Swallow the pills whole and take with food.
  • Has to be taken with food.
Pain
NeurontinHorizant
  • Studies show it's most effective for nerve pain from diabetes, shingles, and fibromyalgia (a painful muscle condition).
  • Can be used with other pain medications.
Sleep
NeurontinHorizant
  • Neurontin (Gabapentin) is likely to cause some side effects, including memory problems, drowsiness, dizziness, or confusion.
  • Horizant (Gabapentin Enacarbil) can make you feel dizzy or sleepy for the first few days or weeks that you take it. Until your body has adjusted to the medication, be very careful getting up from sitting or lying down, and don't drive or use machinery.
Upsides and benefits
NeurontinHorizant
  • Originally used to treat epilepsy (partial seizures), but now it primarily treats neuropathic pain that's caused by nerve stimulation or damage.
  • Studies show it's most effective for nerve pain from diabetes, shingles, and fibromyalgia (a painful muscle condition).
  • It's available as a generic, so it's less expensive than similar medications.
  • Not habit-forming or addictive.
  • Can be used with other pain medications.
  • Only has to be taken once or twice a day.
Downsides and risks
NeurontinHorizant
  • Neurontin (Gabapentin) is likely to cause some side effects, including memory problems, drowsiness, dizziness, or confusion.
  • You can't skip or miss doses since suddenly stopping Neurontin (Gabapentin) can cause seizures. This is even more likely if you drink alcohol, so it might not be the best medication for heavy drinkers.
  • Need to avoid alcohol while on Horizant (Gabapentin Enacarbil).
  • Has to be taken with food.
  • If you want to stop taking this medication, you need to talk to your doctor first since stopping it cold turkey can cause seizures.
  • Not available as a generic.
Tips from our pharmacists for people taking the medication
NeurontinHorizant
  • Side effects are common, but usually manageable.
  • Don't drive while taking Neurontin (Gabapentin) until you know how the medication affects you.
  • Neurontin and generic forms of Gabapentin have the same ingredients as Gralise and Horizant, but are dosed differently. Make sure you know which form you're taking since they are used for different purposes.
  • Take the extended-release tablet with food.
  • Stop taking Neurontin (Gabapentin) slowly over at least one week to avoid getting withdrawal symptoms.
  • Don't stop taking Horizant (Gabapentin Enacarbil) suddenly without telling your doctor.
  • Can make you feel dizzy or drowsy the first few days or weeks that you're taking it.
  • Swallow the pills whole and take with food.
  • Horizant (Gabapentin Enacarbil) is different from other forms of gabapentin (like Neurontin), so these two medications can't be switched or substituted for each other.
Learn more
More about NeurontinSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Neurontin (gabapentin)?
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More about HorizantSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Horizant (gabapentin enacarbil)?
Worth itNot sureNot worth it