Compare Neurontin vs. Imitrex

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Neurontin
(Gabapentin)

Imitrex
(Sumatriptan)

Treats tingling and burning nerve pain. Neurontin (Gabapentin) is an old seizure disorder medicine that's now used to treat nerve-related pain caused by different conditions.Treats migraine headaches. Imitrex (Sumatriptan) is an excellent choice for acute migraine relief, but you might need another medication to prevent headaches.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.56Neurontin
Reviews for Neurontin
57%
of people (All ages) say Neurontin is worth it
40%
say it works well
19%
say it's a big hassle
620 reviews
Have you used Neurontin (Gabapentin)?
Worth itNot sureNot worth it
Reviews for Imitrex
74%
-17% worse vs. Neurontin
68%
-28% worse vs. Neurontin
19%
Same vs. Neurontin
Have you used Imitrex (Sumatriptan)?
Worth itNot sureNot worth it
Side effects
NeurontinImitrex
  • Flatulence 1%
  • Thinking abnormal 2%
  • Amblyopia 2%
  • Accidental injury 2%
  • Constipation 2%
  • Vomiting 2%
  • Ataxia 3%
More Neurontin side effects »
  • Pain - location specified 1%
  • Malaise/fatigue 2%
  • Paresthesia (all types) 1%
  • Sensation warm/cold 1%
  • Atypical sensations 1%
  • Pain and other pressure sensations 2%
  • Chest - pain/tightness/pressure and/or heaviness 1%
  • Neck/throat/jaw - pain/ tightness/pressure 2%
  • Vertigo 2%
  • Other - pressure/tightness/ heaviness 1%
More Imitrex side effects »
How it works
NeurontinImitrex
Neurontin (Gabapentin) is an antiepileptic and nerve pain reliever. Researchers don't know exactly how it works, but it has a similar structure to GABA, a neurotransmitter that calms nerves in the brain and spinal cord.Imitrex (Sumatriptan) is a triptan medication that treats migraine headaches. It releases serotonin, which lowers the inflammation that causes headaches.
Type of medication
NeurontinImitrex
Prescription onlyLower-cost generic availablePrescription onlyLower-cost generic available
Available as
NeurontinImitrex
  • Pill
  • Oral solution
  • Pill
  • Injection
  • Nasal spray
Used for
NeurontinImitrex
Risk factors for serious side effects
NeurontinImitrex
  • Children ages 3 to 12
  • Taking with alcohol or drugs
  • Stopping Neurontin (Gabapentin) suddenly
Detailed Neurontin (Gabapentin) risks & warnings »
  • History of heart problems
  • High blood pressure
  • High cholesterol
  • Diabetes
  • Being overweight or obese
Detailed Imitrex (Sumatriptan) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Food
NeurontinImitrex
  • Take the extended-release tablet with food.
No food related info.
Pain
NeurontinImitrex
  • Studies show it's most effective for nerve pain from diabetes, shingles, and fibromyalgia (a painful muscle condition).
No pain related info.
Sleep
NeurontinImitrex
  • Neurontin (Gabapentin) is likely to cause some side effects, including memory problems, drowsiness, dizziness, or confusion.
  • Imitrex (Sumatriptan) can make you drowsy, so avoid activities that need you to be fully alert until you know how it affects you.
Upsides and benefits
NeurontinImitrex
  • Originally used to treat epilepsy (partial seizures), but now it primarily treats neuropathic pain that's caused by nerve stimulation or damage.
  • Studies show it's most effective for nerve pain from diabetes, shingles, and fibromyalgia (a painful muscle condition).
  • It's available as a generic, so it's less expensive than similar medications.
  • Comes in several forms. Ask your doctor if you should use the pill, nasal spray, patch, or injection.
  • A combination of forms can be used if symptoms do not improve.
  • The nasal spray and injectable forms work very quickly.
  • It's generally safe to use if you are pregnant.
  • Comes in a generic form, so it can be pretty cheap.
Downsides and risks
NeurontinImitrex
  • Neurontin (Gabapentin) is likely to cause some side effects, including memory problems, drowsiness, dizziness, or confusion.
  • You can't skip or miss doses since suddenly stopping Neurontin (Gabapentin) can cause seizures. This is even more likely if you drink alcohol, so it might not be the best medication for heavy drinkers.
  • The oral and nasal versions of Imitrex (Sumatriptan) have an unpleasant after-taste.
  • Does not prevent migraine headaches; it only treats them once they start.
  • Must wait 1 hour before using second injection.
  • Can cause rebound (more) headaches if Imitrex (Sumatriptan) is used too often.
  • Need to have your blood pressure checked often, especially if you're pregnant.
Tips from our pharmacists for people taking the medication
NeurontinImitrex
  • Side effects are common, but usually manageable.
  • Don't drive while taking Neurontin (Gabapentin) until you know how the medication affects you.
  • Neurontin and generic forms of Gabapentin have the same ingredients as Gralise and Horizant, but are dosed differently. Make sure you know which form you're taking since they are used for different purposes.
  • Take the extended-release tablet with food.
  • Stop taking Neurontin (Gabapentin) slowly over at least one week to avoid getting withdrawal symptoms.
  • Take it as soon as your headache starts.
  • If you use the nasal spray, be sure to blow your nose before using it.
  • If you use the patch, put it on a dry area free of scars, tattoos, or other cuts and scrapes. Be sure to press the button to activate it.
  • If you use the injection, you can use a second injection if you still have a headache after an hour. If you have symptoms 2 hours after the injection, switch to the pill version.
  • Imitrex (Sumatriptan) can make you drowsy, so avoid activities that need you to be fully alert until you know how it affects you.
  • Lie down in a dark room after taking Imitrex (Sumatriptan) to help ease the pain.
Learn more
More about NeurontinSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Neurontin (Gabapentin)?
Worth itNot sureNot worth it
More about ImitrexSide effectsReviews & ratingsFDA package insert
Have you used Imitrex (Sumatriptan)?
Worth itNot sureNot worth it