Compare Neurontin vs. Lidocaine

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Neurontin
(gabapentin)

Lidoderm
(lidocaine)

Treats tingling and burning nerve pain. Neurontin (Gabapentin) is an old seizure disorder medicine that's now used to treat nerve-related pain caused by different conditions.Treats nerve pain. Lidoderm (Lidocaine) patches work well by releasing a local anesthetic into the skin and relieving pain by targeting damaged nerves.
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Coupons for Neurontin
Best available price for 90 (300mg) capsules of gabapentin
Coupons for Lidocaine
Best available price for 100 (100ml of 2%) bottle of topical solutions of lidocaine
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.56Neurontin
Reviews for Neurontin
57%
of people (All ages) say Neurontin is worth it
40%
say it works well
19%
say it's a big hassle
620 reviews
Have you used Neurontin (gabapentin)?
Worth itNot sureNot worth it
Reviews for Lidocaine
67%
-10% worse vs. Neurontin
72%
-32% worse vs. Neurontin
22%
+3% better vs. Neurontin
Have you used Lidoderm (lidocaine)?
Worth itNot sureNot worth it
Side effects
NeurontinLidocaine
  • Dizziness 21%
  • Drowsiness 16%
  • Leg or ankle swelling 6%
  • Muscle weakness 1%
  • Diarrhea 2%
  • Infection 2%
  • Dry mouth 3%
  • Constipation 2%
  • Accidental injury 2%
  • Vomiting 2%
More Neurontin side effects »

The Lidocaine FDA package insert doesn’t have numbers about how common side effects are.

More about Lidocaine side effects »
How it works
NeurontinLidocaine
Neurontin (Gabapentin) is an antiepileptic and nerve pain reliever. Researchers don't know exactly how it works, but it has a similar structure to GABA, a neurotransmitter that calms nerves in the brain and spinal cord.Lidoderm (Lidocaine) is a local anesthetic. It absorbs into your skin where it targets damaged nerves and relieves burning pain.
Type of medication
NeurontinLidocaine
Prescription onlyPrescription only
Available as
NeurontinLidocaine
  • Pill
  • Oral solution
  • Cream, gel, or ointment
  • Jelly
  • Spray
  • Topical solution
  • Patch
Used for
NeurontinLidocaine
Risk factors for serious side effects
NeurontinLidocaine
  • Children ages 3 to 12
  • Taking with alcohol or drugs
  • Stopping Neurontin (Gabapentin) suddenly
Detailed Neurontin (gabapentin) risks & warnings »
  • Use of heating pad on skin
  • Applying patch to red, irritated or broken skin
  • Leaving patch on for more than 12 hours
  • Using patch on a very large area
  • Older age and lower body weight
Detailed Lidoderm (lidocaine) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Food
NeurontinLidocaine
  • Take the extended-release tablet with food.
No food related info.
Pain
NeurontinLidocaine
  • Studies show it's most effective for nerve pain from diabetes, shingles, and fibromyalgia (a painful muscle condition).
  • Lidoderm (Lidocaine) can treat pain better for people who can't take oral pain medications due to allergies or bad side effects.
  • Has been shown to relieve nerve pain due to shingles for up to 12 hours at a time.
Sleep
NeurontinLidocaine
  • Neurontin (Gabapentin) is likely to cause some side effects, including memory problems, drowsiness, dizziness, or confusion.
No sleep related info.
Upsides and benefits
NeurontinLidocaine
  • Originally used to treat epilepsy (partial seizures), but now it primarily treats neuropathic pain that's caused by nerve stimulation or damage.
  • Studies show it's most effective for nerve pain from diabetes, shingles, and fibromyalgia (a painful muscle condition).
  • It's available as a generic, so it's less expensive than similar medications.
  • Lidoderm (Lidocaine) can treat pain better for people who can't take oral pain medications due to allergies or bad side effects.
  • Has been shown to relieve nerve pain due to shingles for up to 12 hours at a time.
  • Patches can be cut into smaller pieces to best fit the areas of skin they need to be used on.
Downsides and risks
NeurontinLidocaine
  • Neurontin (Gabapentin) is likely to cause some side effects, including memory problems, drowsiness, dizziness, or confusion.
  • You can't skip or miss doses since suddenly stopping Neurontin (Gabapentin) can cause seizures. This is even more likely if you drink alcohol, so it might not be the best medication for heavy drinkers.
  • Can cause skin irritation after using it the first time, but for most people it's mild and goes away in a few minutes or hours.
  • Used patches contain enough medicine to be dangerous to children and pets, so store and dispose of the patches in a safe place out of their reach.
  • Might not be the best choice if you've had allergic reactions to numbing medications (local anesthetics) in the past.
  • Even though only small amounts of Lidoderm (Lidocaine) are absorbed into the body through the skin, if you're taking medications that treat arrhythmias, Lidoderm (Lidocaine) can affect how they work.
  • Patches shouldn't be left on for more than 12 hours, used on very large areas of skin, or covered with a heating pad.
Tips from our pharmacists for people taking the medication
NeurontinLidocaine
  • Side effects are common, but usually manageable.
  • Don't drive while taking Neurontin (Gabapentin) until you know how the medication affects you.
  • Neurontin and generic forms of Gabapentin have the same ingredients as Gralise and Horizant, but are dosed differently. Make sure you know which form you're taking since they are used for different purposes.
  • Take the extended-release tablet with food.
  • Stop taking Neurontin (Gabapentin) slowly over at least one week to avoid getting withdrawal symptoms.
  • Starts working with the first dose, but full effects can take longer.
  • Remove the protective lining on the patch before applying the patch to unbroken skin.
  • Leave the patch on for up to 12 hours during a 24 hour period.
  • You can cut the patches to create a custom fit for the area of skin you need to apply it to.
  • Don't place any tight wraps or heating pads over the patch while it's on.
  • Make sure not to touch your eyes after touching the patch. Always wash your hands after putting it on or taking it off.
Learn more
More about NeurontinSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Neurontin (gabapentin)?
Worth itNot sureNot worth it
More about LidocaineSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Lidoderm (lidocaine)?
Worth itNot sureNot worth it