Compare Neurontin vs. Lyrica

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Neurontin
(Gabapentin)

Lyrica
(Pregabalin)

Treats tingling and burning nerve pain. Neurontin (Gabapentin) is an old seizure disorder medicine that's now used to treat nerve-related pain caused by different conditions.Treats nerve pain and prevents seizures. Lyrica (Pregabalin) works well as an add-on medicine for seizures and fibromyalgia, but it's especially effective for nerve-related pain after shingles. Not available as a generic, so it might be expensive.
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.56Neurontin
Reviews for Neurontin (Gabapentin)
57%
of people (All ages) say Neurontin (Gabapentin) is worth it
40%
say it works well
19%
say it's a big hassle
620 reviews
Have you used Neurontin (Gabapentin)?
Worth itNot sureNot worth it
Reviews for Lyrica (Pregabalin)
47%
10% vs. Neurontin (Gabapentin)
42%
+2% vs. Neurontin (Gabapentin)
32%
13% vs. Neurontin (Gabapentin)
Have you used Lyrica (Pregabalin)?
Worth itNot sureNot worth it
Side effects
NeurontinLyrica
  • Dizziness 9%
  • Hostility 5%
  • Drowsiness 4%
  • Mood swings 3%
  • Weight increase 3%
  • Bronchitis 3%
  • Dry mouth 2%
  • Fatigue 2%
  • Abnormal increase in muscle activity 2%
  • Respiratory infection 2%
More Neurontin side effects »
  • Dizziness 36%
  • Nerve damage 34%
  • Lack of muscle coordination 24%
  • Drowsiness 17%
  • Weight gain 15%
  • Constipation 13%
  • Weight increased 12%
  • Dry mouth 12%
  • Leg or ankle swelling 12%
  • Vision blurred 11%
More Lyrica side effects »
How it works
NeurontinLyrica
Neurontin (Gabapentin) is an antiepileptic and nerve pain reliever. Researchers don't know exactly how it works, but it has a similar structure to GABA, a neurotransmitter that calms nerves in the brain and spinal cord.Lyrica (Pregabalin) is a nerve pain reliever. Researchers don't know exactly how it works, but it has a similar structure to GABA, a neurotransmitter that calms nerves in the brain and spinal cord.
Type of medication
NeurontinLyrica
Anticonvulsant
GABA analog
Prescription only
Anticonvulsant
GABA analog
Prescription only
Available as
NeurontinLyrica
  • Pill
  • Oral solution
  • Pill
  • Liquid
Used for (click to learn more)
NeurontinLyrica
Risk factors for serious side effects
NeurontinLyrica
  • Children ages 3 to 12
  • Taking with alcohol or drugs
  • Stopping Neurontin (Gabapentin) suddenly
Detailed risks & warnings »
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • History of unusual swelling (angioedema)
  • Taking other medications that can angioedema
  • History of cardiovascular disease
Detailed risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Alcohol
NeurontinLyrica
No alcohol related info.
  • It's not safe to take this medication with alcohol or other drugs that make you drowsy.
Food
NeurontinLyrica
  • Take the extended-release tablet with food.
No food related info.
Pain
NeurontinLyrica
  • Studies show it's most effective for nerve pain from diabetes, shingles, and fibromyalgia (a painful muscle condition).
  • Has a higher risk than other pain medicines of affecting your heart rate or rhythm, so it might not be the best choice if you have cardiovascular disease (previous heart attack, stroke, fast/uncontrolled heart rate, or irregular heartbeat).
Sleep
NeurontinLyrica
  • Neurontin (Gabapentin) is likely to cause some side effects, including memory problems, drowsiness, dizziness, or confusion.
  • Lyrica (Pregabalin) is likely to cause some side effects, including memory problems, drowsiness, dizziness, and confusion.
  • Can make you drowsy or dizzy.
Upsides and benefits
NeurontinLyrica
  • Originally used to treat epilepsy (partial seizures), but now it primarily treats neuropathic pain that's caused by nerve stimulation or damage.
  • Studies show it's most effective for nerve pain from diabetes, shingles, and fibromyalgia (a painful muscle condition).
  • It's available as a generic, so it's less expensive than similar medications.
  • Relieves nerve-related (neuropathic) pain caused by different conditions including diabetes, shingles (herpes zoster), fibromyalgia, and spinal cord damage.
  • Studies show that lower doses of Lyrica (Pregabalin) cause fewer side effects and still relieve pain just as well as higher doses.
  • Also used in combination with other medications to treat epilepsy (partial seizures).
Downsides and risks
NeurontinLyrica
  • Neurontin (Gabapentin) is likely to cause some side effects, including memory problems, drowsiness, dizziness, or confusion.
  • You can't skip or miss doses since suddenly stopping Neurontin (Gabapentin) can cause seizures. This is even more likely if you drink alcohol, so it might not be the best medication for heavy drinkers.
  • Not available as a generic, so it can be pricey.
  • You can't skip or miss doses since suddenly stopping Lyrica (Pregabalin) can cause seizures.
  • Lyrica (Pregabalin) is likely to cause some side effects, including memory problems, drowsiness, dizziness, and confusion.
  • Has a higher risk than other pain medicines of affecting your heart rate or rhythm, so it might not be the best choice if you have cardiovascular disease (previous heart attack, stroke, fast/uncontrolled heart rate, or irregular heartbeat).
Tips from our pharmacists for people taking the medication
NeurontinLyrica
  • Side effects are common, but usually manageable.
  • Don't drive while taking Neurontin (Gabapentin) until you know how the medication affects you.
  • Neurontin and generic forms of Gabapentin have the same ingredients as Gralise and Horizant, but are dosed differently. Make sure you know which form you're taking since they are used for different purposes.
  • Take the extended-release tablet with food.
  • Stop taking Neurontin (Gabapentin) slowly over at least one week to avoid getting withdrawal symptoms.
  • Some people feel relief from pain in a week.
  • Can make you drowsy or dizzy.
  • Don't stop taking it suddenly without talking to your doctor. You'll need to slowly lower your dose over at least a week to avoid withdrawal symptoms.
  • Tell your doctor if you have unexplained confusion or changes in your thoughts or behavior.
  • It's not safe to take this medication with alcohol or other drugs that make you drowsy.
Learn more
More about NeurontinSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Neurontin (Gabapentin)?
Worth itNot sureNot worth it
More about LyricaSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Lyrica (Pregabalin)?
Worth itNot sureNot worth it