Compare Neurontin vs. Lyrica

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Neurontin
(gabapentin)

Lyrica
(pregabalin)

Treats tingling and burning nerve pain. Neurontin (Gabapentin) is an old seizure disorder medicine that's now used to treat nerve-related pain caused by different conditions.Treats nerve pain and prevents seizures. Lyrica (Pregabalin) works well as an add-on medicine for seizures and fibromyalgia, but it's especially effective for nerve-related pain after shingles. Not available as a generic, so it might be expensive.
Find lowest prices
Powered by GoodRxSave on your next prescription. Be sure you’re getting the lowest price for your medication, even if you have insurance.
Coupons for
Prices and coupon for 90 (300mg) capsules of gabapentin
Coupons for
Prices and coupon for 60 (75mg) capsules of pregabalin
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.56Neurontin
Reviews for Neurontin (gabapentin)
57%
of people (All ages) say Neurontin (gabapentin) is worth it
40%
say it works well
19%
say it's a big hassle
620 reviews
Have you used Neurontin (gabapentin)?
Worth itNot sureNot worth it
Reviews for Lyrica (pregabalin)
47%
-10% worse vs. Neurontin (gabapentin)
42%
+2% better vs. Neurontin (gabapentin)
32%
-13% worse vs. Neurontin (gabapentin)
Have you used Lyrica (pregabalin)?
Worth itNot sureNot worth it
Side effects
NeurontinLyrica
  • Dizziness 21%
  • Drowsiness 16%
  • Leg or ankle swelling 6%
  • Muscle weakness 1%
  • Diarrhea 2%
  • Infection 2%
  • Dry mouth 3%
  • Constipation 2%
  • Accidental injury 2%
  • Vomiting 2%
More Neurontin side effects »
  • Nerve damage 6%
  • Dizziness 3%
  • Lack of muscle coordination 5%
  • Accidental injury 2%
  • Chest pain 3%
  • Leg or ankle swelling 2%
  • Muscle weakness 2%
  • Drowsiness 1%
  • Passing gas 2%
  • Dry mouth 2%
More Lyrica side effects »
How it works
NeurontinLyrica
Neurontin (Gabapentin) is an antiepileptic and nerve pain reliever. Researchers don't know exactly how it works, but it has a similar structure to GABA, a neurotransmitter that calms nerves in the brain and spinal cord.Lyrica (Pregabalin) is a nerve pain reliever. Researchers don't know exactly how it works, but it has a similar structure to GABA, a neurotransmitter that calms nerves in the brain and spinal cord.
Type of medication
NeurontinLyrica
Prescription only
Prescription only
Available as
NeurontinLyrica
  • Pill
  • Oral solution
  • Pill
  • Liquid
Used for
NeurontinLyrica
Risk factors for serious side effects
NeurontinLyrica
    • Children ages 3 to 12
      • Taking with alcohol or drugs
      • Stopping Neurontin (Gabapentin) suddenly
      Detailed Neurontin (gabapentin) risks & warnings »
        • Taking with alcohol
        • Taking other medicines that make you less alert
        • History of unusual swelling (angioedema)
        • Taking other medications that can angioedema
        • History of cardiovascular disease
        • Taking with certain diabetes medications
        • Stopping Lyrica (Pregabalin) suddenly
          • Both male and females taking Lyrica (Pregabalin)
          Detailed Lyrica (pregabalin) risks & warnings »
          Pregnancy

          Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          Price
          NeurontinLyrica
          No price related info.
          • Not available as a generic, so it can be pricey.
          Alcohol
          NeurontinLyrica
          No alcohol related info.
          • It's not safe to take this medication with alcohol or other drugs that make you drowsy.
          Food
          NeurontinLyrica
          • Take the extended-release tablet with food.
          No food related info.
          Pain
          NeurontinLyrica
          • Studies show it's most effective for nerve pain from diabetes, shingles, and fibromyalgia (a painful muscle condition).
          • Has a higher risk than other pain medicines of affecting your heart rate or rhythm, so it might not be the best choice if you have cardiovascular disease (previous heart attack, stroke, fast/uncontrolled heart rate, or irregular heartbeat).
          Sleep
          NeurontinLyrica
          • Neurontin (Gabapentin) is likely to cause some side effects, including memory problems, drowsiness, dizziness, or confusion.
          • Lyrica (Pregabalin) is likely to cause some side effects, including memory problems, drowsiness, dizziness, and confusion.
          • Can make you drowsy or dizzy.
          Upsides and benefits
          NeurontinLyrica
          • Originally used to treat epilepsy (partial seizures), but now it primarily treats neuropathic pain that's caused by nerve stimulation or damage.
          • Studies show it's most effective for nerve pain from diabetes, shingles, and fibromyalgia (a painful muscle condition).
          • It's available as a generic, so it's less expensive than similar medications.
          • Relieves nerve-related (neuropathic) pain caused by different conditions including diabetes, shingles (herpes zoster), fibromyalgia, and spinal cord damage.
          • Studies show that lower doses of Lyrica (Pregabalin) cause fewer side effects and still relieve pain just as well as higher doses.
          • Also used in combination with other medications to treat epilepsy (partial seizures).
          Downsides and risks
          NeurontinLyrica
          • Neurontin (Gabapentin) is likely to cause some side effects, including memory problems, drowsiness, dizziness, or confusion.
          • You can't skip or miss doses since suddenly stopping Neurontin (Gabapentin) can cause seizures. This is even more likely if you drink alcohol, so it might not be the best medication for heavy drinkers.
          • Not available as a generic, so it can be pricey.
          • You can't skip or miss doses since suddenly stopping Lyrica (Pregabalin) can cause seizures.
          • Lyrica (Pregabalin) is likely to cause some side effects, including memory problems, drowsiness, dizziness, and confusion.
          • Has a higher risk than other pain medicines of affecting your heart rate or rhythm, so it might not be the best choice if you have cardiovascular disease (previous heart attack, stroke, fast/uncontrolled heart rate, or irregular heartbeat).
          Tips from our pharmacists for people taking the medication
          NeurontinLyrica
          • Side effects are common, but usually manageable.
          • Don't drive while taking Neurontin (Gabapentin) until you know how the medication affects you.
          • Neurontin and generic forms of Gabapentin have the same ingredients as Gralise and Horizant, but are dosed differently. Make sure you know which form you're taking since they are used for different purposes.
          • Take the extended-release tablet with food.
          • Stop taking Neurontin (Gabapentin) slowly over at least one week to avoid getting withdrawal symptoms.
          • Some people feel relief from pain in a week.
          • Can make you drowsy or dizzy.
          • Don't stop taking it suddenly without talking to your doctor. You'll need to slowly lower your dose over at least a week to avoid withdrawal symptoms.
          • Tell your doctor if you have unexplained confusion or changes in your thoughts or behavior.
          • It's not safe to take this medication with alcohol or other drugs that make you drowsy.
          Learn more
          More about NeurontinSide effectsReviews & ratingsAlternativesFDA package insert
          Have you used Neurontin (gabapentin)?
          Worth itNot sureNot worth it
          More about LyricaSide effectsReviews & ratingsAlternativesFDA package insert
          Have you used Lyrica (pregabalin)?
          Worth itNot sureNot worth it