Compare Neurontin vs. Oleptro

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Neurontin
(gabapentin)

Oleptro
(trazodone)

Treats tingling and burning nerve pain. Neurontin (Gabapentin) is an old seizure disorder medicine that's now used to treat nerve-related pain caused by different conditions.Improves mood and helps you sleep. Oleptro (Trazodone) works well as a sleep aid, but has more side effects when used at higher doses for treating depression.
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Prices and coupon for 90 (300mg) capsules of gabapentin
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Prices and coupon for 30 (50mg) tablets of trazodone
Reviews & ratings
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4.56Neurontin
Reviews for Neurontin (gabapentin)
57%
of people (All ages) say Neurontin (gabapentin) is worth it
40%
say it works well
19%
say it's a big hassle
620 reviews
Have you used Neurontin (gabapentin)?
Worth itNot sureNot worth it
Reviews for Oleptro (trazodone)
73%
+16% better vs. Neurontin (gabapentin)
49%
+9% better vs. Neurontin (gabapentin)
24%
-5% worse vs. Neurontin (gabapentin)
Have you used Oleptro (trazodone)?
Worth itNot sureNot worth it
Side effects
NeurontinOleptro
  • Dizziness 21%
  • Drowsiness 16%
  • Leg or ankle swelling 6%
  • Muscle weakness 1%
  • Diarrhea 2%
  • Infection 2%
  • Dry mouth 3%
  • Constipation 2%
  • Accidental injury 2%
  • Vomiting 2%
More Neurontin side effects »
  • Somnolence/sedation 27%
  • Drowsiness 21%
  • Dry mouth 14%
  • Headache 6%
  • Dizziness/lightheadedness 13%
  • Dizziness 13%
  • Nausea 8%
  • Fatigue 7%
More Oleptro side effects »
How it works
NeurontinOleptro
Neurontin (Gabapentin) is an antiepileptic and nerve pain reliever. Researchers don't know exactly how it works, but it has a similar structure to GABA, a neurotransmitter that calms nerves in the brain and spinal cord.Oleptro (Trazodone) is a serotonin reuptake inhibitor (SRI) antidepressant. It increases serotonin activity in the brain, which regulates mood.
Type of medication
NeurontinOleptro
Prescription only
Prescription only
Available as
NeurontinOleptro
  • Pill
  • Oral solution
  • Pill
  • Extended release
Used for
NeurontinOleptro
Risk factors for serious side effects
NeurontinOleptro
    • Children ages 3 to 12
      • Taking with alcohol or drugs
      • Stopping Neurontin (Gabapentin) suddenly
      Detailed Neurontin (gabapentin) risks & warnings »
      • Age 24 years or younger
      • History of seizures
      • Alcoholism
      • Eating disorder
      • Higher dose
      • Drug interactions
        • Age 65 years or older
        • Alcohol
        • Taking other medicines that make you less alert
        Detailed Oleptro (trazodone) risks & warnings »
        Pregnancy

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        Food
        NeurontinOleptro
        • Take the extended-release tablet with food.
        No food related info.
        Pain
        NeurontinOleptro
        • Studies show it's most effective for nerve pain from diabetes, shingles, and fibromyalgia (a painful muscle condition).
        No pain related info.
        Sleep
        NeurontinOleptro
        • Neurontin (Gabapentin) is likely to cause some side effects, including memory problems, drowsiness, dizziness, or confusion.
        No sleep related info.
        Upsides and benefits
        NeurontinOleptro
        • Originally used to treat epilepsy (partial seizures), but now it primarily treats neuropathic pain that's caused by nerve stimulation or damage.
        • Studies show it's most effective for nerve pain from diabetes, shingles, and fibromyalgia (a painful muscle condition).
        • It's available as a generic, so it's less expensive than similar medications.
        • Commonly used in lower doses to help treat sleep problems (insomnia).
        • Safer sleep medication than others (benzodiazepines or Unisom) for people age 65 and older.
        • Fewer sexual side effects than many other antidepressants.
        • Has been used for sleep and depression for a long time. There's a lot of information available about how it works and how safe it is.
        • Comes as a generic medication and is cheaper than many other sleep aides.
        • Six out of ten people who use an antidepressant for the first time find that it works for them.
        Downsides and risks
        NeurontinOleptro
        • Neurontin (Gabapentin) is likely to cause some side effects, including memory problems, drowsiness, dizziness, or confusion.
        • You can't skip or miss doses since suddenly stopping Neurontin (Gabapentin) can cause seizures. This is even more likely if you drink alcohol, so it might not be the best medication for heavy drinkers.
        • Not as effective as other medications for depression.
        • More sedating than other antidepressants.
        • Causes more side effects when used at higher doses for depression. Includes sleepiness, dizziness, upset stomach, and irregular heartbeat.
        • Like most antidepressants, can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
        • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
        Tips from our pharmacists for people taking the medication
        NeurontinOleptro
        • Side effects are common, but usually manageable.
        • Don't drive while taking Neurontin (Gabapentin) until you know how the medication affects you.
        • Neurontin and generic forms of Gabapentin have the same ingredients as Gralise and Horizant, but are dosed differently. Make sure you know which form you're taking since they are used for different purposes.
        • Take the extended-release tablet with food.
        • Stop taking Neurontin (Gabapentin) slowly over at least one week to avoid getting withdrawal symptoms.
        • Makes you sleepy. Take at bedtime.
        • Can cause temporary dry mouth and upset stomach.
        • Seek medical attention for unwanted, persistent erection.
        • Tell your doctor if you notice sudden mood changes or unusual thoughts.
        Learn more
        More about NeurontinSide effectsReviews & ratingsAlternativesFDA package insert
        Have you used Neurontin (gabapentin)?
        Worth itNot sureNot worth it
        More about OleptroSide effectsReviews & ratingsAlternativesFDA package insert
        Have you used Oleptro (trazodone)?
        Worth itNot sureNot worth it