Compare Neurontin vs. Pamelor

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Treats tingling and burning nerve pain. Neurontin (Gabapentin) is an old seizure disorder medicine that's now used to treat nerve-related pain caused by different conditions.Improves your mood. Pamelor (Nortriptyline) is a good option for treating depression, especially for people who also have problems with persistent nerve pain.
How it works
Neurontin (Gabapentin) is an antiepileptic and nerve pain reliever. Researchers don't know exactly how it works, but it has a similar structure to GABA, a neurotransmitter that calms nerves in the brain and spinal cord.Pamelor (Nortriptyline) is a tricyclic antidepressant (TCA). It helps improve your mood by altering the levels of serotonin, norepinephrine, and other similar chemicals in your brain.
Type of medication
GABA analog
Prescription only
Tricyclic antidepressant (TCA)
Prescription only
Available as
  • Pill
  • Oral solution
  • Pill
  • Liquid
Used for (click to learn more)
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Reviews & ratings
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Reviews for Neurontin (Gabapentin)
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Side effects
  • Dizziness 21%
  • Drowsiness 16%
  • Lack of muscle coordination 7%
  • Leg or ankle swelling 6%
  • Fatigue 6%
  • Hostility 5%
  • Involuntary eye movement 4%
  • Double vision 4%
  • Tremor 4%
  • Dry mouth 4%
More Neurontin side effects »

We haven’t found good data for Pamelor side effects.

FDA side effect reports for Pamelor »
Risk factors for serious side effects
    • Children ages 3 to 12
      • Taking with alcohol or drugs
      • Stopping Neurontin (Gabapentin) suddenly
      Detailed Neurontin (Gabapentin) risks & warnings »
      • Age 24 years or younger
      • Age 65 years or older
      • Stopping Pamelor (Nortriptyline) suddenly
      • Using other medications that affect serotonin
      • History of heart disease
      • Older age
      • Electrolyte imbalance
      Detailed Pamelor (Nortriptyline) risks & warnings »
      Pregnancy category
      • You can't skip or miss doses since suddenly stopping Neurontin (Gabapentin) can cause seizures. This is even more likely if you drink alcohol, so it might not be the best medication for heavy drinkers.
      No specific alcohol-related info.
      • Take the extended-release tablet with food.
      • Take it with food and/or at bedtime to decrease the potential side effects.
      Kidneys and liver
      No specific kidneys and liver-related info.No specific kidneys and liver-related info.
      No specific sex-related info.No specific sex-related info.
      No specific sleep-related info.
      • Stopping Pamelor (Nortriptyline) suddenly may cause withdrawal symptoms such as nausea, anxiety, agitation, flu-like symptoms, trouble sleeping, and dizziness. Withdrawal symptoms usually occur within 3-5 days of stopping the medication, and go away within 1-2 weeks. Work with your doctor to gradually reduce your dose.
      No specific weight-related info.No specific weight-related info.
      Upsides and benefits
      • Originally used to treat epilepsy (partial seizures), but now it primarily treats neuropathic pain that's caused by nerve stimulation or damage.
      • Studies show it's most effective for nerve pain from diabetes, shingles, and fibromyalgia (a painful muscle condition).
      • It's available as a generic, so it's less expensive than similar medications.
      • Helpful with treating certain types of pain, like migraines or nerve-related pain.
      • Generally well tolerated and has fewer side effects than other medicines in the same class of drugs.
      Downsides and risks
      • Neurontin (Gabapentin) is likely to cause some side effects, including memory problems, drowsiness, dizziness, or confusion.
      • You can't skip or miss doses since suddenly stopping Neurontin (Gabapentin) can cause seizures. This is even more likely if you drink alcohol, so it might not be the best medication for heavy drinkers.
      • Side effects are usually manageable, but can be annoying.
      • Increases the risk of falls, especially when used in the elderly.
      • There's an increased chance of it causing heart problems, especially in people with a history of heart problems.
      Tips from our pharmacists for people taking the medication
      • Side effects are common, but usually manageable.
      • Don't drive while taking Neurontin (Gabapentin) until you know how the medication affects you.
      • Neurontin and generic forms of Gabapentin have the same ingredients as Gralise and Horizant, but are dosed differently. Make sure you know which form you're taking since they are used for different purposes.
      • Take the extended-release tablet with food.
      • Stop taking Neurontin (Gabapentin) slowly over at least one week to avoid getting withdrawal symptoms.
      • Needs to be taken every day for 1 to 2 weeks to start feeling better, and for 6 to 8 weeks to see the full effect of the medication.
      • It's important to keep taking Pamelor (Nortriptyline) even when you feel your symptoms are getting better.
      • Take it with food and/or at bedtime to decrease the potential side effects.
      • Tell your doctor if you notice sudden mood changes or unusual thoughts.
      • If you decide to stop taking Pamelor (Nortriptyline), work with your doctor to slowly get off this medicine to avoid getting withdrawal symptoms.
      Learn more
      More about NeurontinSide effectsReviews & ratingsAlternativesFDA package insert
      More about PamelorSide effectsReviews & ratingsAlternativesFDA package insert