Compare Neurontin vs. Paxil

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Neurontin
(Gabapentin)

Paxil
(Paroxetine)

Treats tingling and burning nerve pain. Neurontin (Gabapentin) is an old seizure disorder medicine that's now used to treat nerve-related pain caused by different conditions.Improves mood and helps you relax. Paxil (Paroxetine) is good for treating depression and anxiety but it causes more weight gain, sleepiness, and withdrawal symptoms than other antidepressants.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
4.542087542087542Neurontin
Reviews for Neurontin (Gabapentin)
57%
of people say Neurontin (Gabapentin) is worth it
39%
say it works well
19%
say it's a big hassle
Reviews for Paxil (Paroxetine)
52%
5% vs. Neurontin (Gabapentin)
39%
Same vs. Neurontin (Gabapentin)
23%
4% vs. Neurontin (Gabapentin)
Side effects
NeurontinPaxil
  • Dizziness 21%
  • Drowsiness 16%
  • Lack of muscle coordination 7%
  • Leg or ankle swelling 6%
  • Fatigue 6%
  • Hostility 5%
  • Involuntary eye movement 4%
  • Double vision 4%
  • Tremor 4%
  • Dry mouth 4%
More Neurontin side effects »
  • Abnormal ejaculation† 27%
  • Ejaculatory disturbance 26%
  • Nausea 22%
  • Dry mouth 19%
  • Drowsiness 17%
  • Lower sex drive 11%
  • Diarrhea 11%
  • Sleep difficulty 11%
  • Constipation 10%
  • Decreased libido 10%
More Paxil side effects »
How it works
NeurontinPaxil
Neurontin (Gabapentin) is an antiepileptic and nerve pain reliever. Researchers don't know exactly how it works, but it has a similar structure to GABA, a neurotransmitter that calms nerves in the brain and spinal cord.Paxil (Paroxetine) is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It increases serotonin activity in the brain, which regulates mood.
Type of medication
NeurontinPaxil
Anticonvulsant
GABA analog
Prescription only
Antidepressant
Selective serotonin reuptake inhibitor (SSRI)
Prescription only
Available as
NeurontinPaxil
  • Pill
  • Oral solution
  • Pill
  • Extended release tablet
  • Liquid
Used for (click to learn more)
NeurontinPaxil
How well it works for depression
The free Iodine Start program helps people track how well they are improving, and find the right antidepressant faster.
The free Iodine Start program (personal reports and coaching) is currently only for antidepressants. For now, you can read our pharmacist info about this medication.Learn more about Neurontin (Gabapentin)

After 4 weeks using Start and Paxil (Paroxetine), here’s how much better people feel.

Risk factors for serious side effects
NeurontinPaxil
    • Children ages 3 to 12
      • Taking with alcohol or drugs
      • Stopping Neurontin (Gabapentin) suddenly
      Detailed Neurontin (Gabapentin) risks & warnings »
      • Age 24 years or younger
      • Using other medications that affect serotonin
      • Stopping Paxil (Paroxetine) suddenly
      • Taking other blood-thinning drugs
        • History of bipolar disorder
        • At risk for bipolar disorder
          Detailed Paxil (Paroxetine) risks & warnings »
          Pregnancy category
          NeurontinPaxil
          CFDA pregnancy category (Weigh risks vs. benefits)

          Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          See the FDA package insert
          DFDA pregnancy category (Weigh risks vs. benefits)

          Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          See the FDA package insert
          Alcohol
          • You can't skip or miss doses since suddenly stopping Neurontin (Gabapentin) can cause seizures. This is even more likely if you drink alcohol, so it might not be the best medication for heavy drinkers.
          No specific alcohol-related info.
          Food
          • Take the extended-release tablet with food.
          • Take with food to avoid upset stomach.
          Kidneys and liver
          No specific kidneys and liver-related info.No specific kidneys and liver-related info.
          Sex
          No specific sex-related info.
          • Can cause more sexual side effects like low libido and an inability to orgasm or ejaculate than most antidepressants.
          • Paxil (Paroxetine) can cause lower sex drive or difficulty having an orgasm. If the problem persists after the first 2 to 3 months, you can talk to your doctor about alternative antidepressants or performance-enhancing medications.
          Sleep
          • Neurontin (Gabapentin) is likely to cause some side effects, including memory problems, drowsiness, dizziness, or confusion.
          • It causes drowsiness, so it's good for people who have trouble sleeping.
          • Stopping Paxil (Paroxetine) suddenly may cause withdrawal symptoms such as nausea, anxiety, agitation, flu-like symptoms, trouble sleeping, and dizziness. Withdrawal symptoms usually occur within 3 days of stopping the medication, and go away within 1 to 2 weeks. Work with your doctor to gradually reduce your dose.
          Weight
          No specific weight-related info.
          • More likely to cause minor weight gain (1 to 5 pounds) or make you feel sick if you miss a dose than other antidepressants.
          • Can cause weight gain, which can be helpful if you've recently lost weight or have a low appetite.
          Upsides and benefits
          NeurontinPaxil
          • Originally used to treat epilepsy (partial seizures), but now it primarily treats neuropathic pain that's caused by nerve stimulation or damage.
          • Studies show it's most effective for nerve pain from diabetes, shingles, and fibromyalgia (a painful muscle condition).
          • It's available as a generic, so it's less expensive than similar medications.
          • Effective at relieving depression and anxiety symptoms.
          • Lowers relapse rates of depression and anxiety disorders, including OCD, panic disorder, social anxiety disorder, and generalized anxiety disorder.
          • It causes drowsiness, so it's good for people who have trouble sleeping.
          • Can cause weight gain, which can be helpful if you've recently lost weight or have a low appetite.
          • Six out of ten people who use an antidepressant for the first time find that it works for them.
          Downsides and risks
          NeurontinPaxil
          • Neurontin (Gabapentin) is likely to cause some side effects, including memory problems, drowsiness, dizziness, or confusion.
          • You can't skip or miss doses since suddenly stopping Neurontin (Gabapentin) can cause seizures. This is even more likely if you drink alcohol, so it might not be the best medication for heavy drinkers.
          • Can cause more sexual side effects like low libido and an inability to orgasm or ejaculate than most antidepressants.
          • More likely to cause minor weight gain (1 to 5 pounds) or make you feel sick if you miss a dose than other antidepressants.
          • Can harm an unborn child, so you can't take it if you're pregnant.
          • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than age 24.
          • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
          Tips from our pharmacists for people taking the medication
          NeurontinPaxil
          • Side effects are common, but usually manageable.
          • Don't drive while taking Neurontin (Gabapentin) until you know how the medication affects you.
          • Neurontin and generic forms of Gabapentin have the same ingredients as Gralise and Horizant, but are dosed differently. Make sure you know which form you're taking since they are used for different purposes.
          • Take the extended-release tablet with food.
          • Stop taking Neurontin (Gabapentin) slowly over at least one week to avoid getting withdrawal symptoms.
          • Take with food to avoid upset stomach.
          • Takes about 8 to 12 weeks to see the medication's full effects on your mood.
          • Stop taking it slowly to avoid getting withdrawal symptoms.
          • Tell your doctor if you notice sudden mood changes or unusual thoughts.
          • The controlled-release (CR) tablet can cause less nausea than other forms.
          • Don’t crush, break, or chew the Paxil (Paroxetine) controlled-release tablet or the Pexeva film-coated tablets.
          • It’s best to take Paxil (Paroxetine) in the morning, except Brisdelle, which can be taken at bedtime.
          Learn more
          More about NeurontinSide effectsReviews & ratingsAlternativesFDA package insert
          More about PaxilSide effectsReviews & ratingsAlternativesFDA package insert