Compare Neurontin vs. Propranolol

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Neurontin
(Gabapentin)

Inderal
(Propranolol)

Treats tingling and burning nerve pain. Neurontin (Gabapentin) is an old seizure disorder medicine that's now used to treat nerve-related pain caused by different conditions.Lowers blood pressure and controls heart rate. Inderal (Propranolol) is good for treating many heart problems and other problems in the body, but it has more side effects than other beta blockers. You can't miss doses.
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Reviews & ratings
Button Group. All currently active
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4.542087542087542Neurontin
Reviews for Neurontin (Gabapentin)
57%
of people say Neurontin (Gabapentin) is worth it
39%
say it works well
19%
say it's a big hassle
Reviews for Inderal (Propranolol)
62%
+5% vs. Neurontin (Gabapentin)
58%
+19% vs. Neurontin (Gabapentin)
17%
+2% vs. Neurontin (Gabapentin)
Side effects
NeurontinPropranolol
  • Dizziness 21%
  • Drowsiness 16%
  • Lack of muscle coordination 7%
  • Leg or ankle swelling 6%
  • Fatigue 6%
  • Hostility 5%
  • Involuntary eye movement 4%
  • Double vision 4%
  • Tremor 4%
  • Dry mouth 4%
More Neurontin side effects »
  • Dizziness 5%
  • Fatigue 4%
More Propranolol side effects »
How it works
NeurontinPropranolol
Neurontin (Gabapentin) is an antiepileptic and nerve pain reliever. Researchers don't know exactly how it works, but it has a similar structure to GABA, a neurotransmitter that calms nerves in the brain and spinal cord.Inderal (Propranolol) is an alpha and beta blocker. It lowers blood pressure by slowing heart rate, relaxing blood vessels, and lowering the body's fight-or-flight response.
Type of medication
NeurontinPropranolol
Anticonvulsant
GABA analog
Prescription only
Antihypertensive
Beta blocker
Prescription only
Available as
NeurontinPropranolol
  • Pill
  • Oral solution
  • Pill
  • Extended release
  • Liquid
Used for (click to learn more)
NeurontinPropranolol
Risk factors for serious side effects
NeurontinPropranolol
    • Children ages 3 to 12
      • Taking with alcohol or drugs
      • Stopping Neurontin (Gabapentin) suddenly
      Detailed Neurontin (Gabapentin) risks & warnings »
      • Suddenly stopping Inderal (Propranolol)
        • Major surgery requiring anesthesia
        • Diabetes
          • Concurrent use of non-dihydropyridine calcium channel blockers, digoxin or clonidine
            Detailed Inderal (Propranolol) risks & warnings »
            Pregnancy category
            NeurontinPropranolol
            CFDA pregnancy category (Weigh risks vs. benefits)

            Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

            See the FDA package insert
            CFDA pregnancy category (Weigh risks vs. benefits)

            Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

            See the FDA package insert
            Alcohol
            • You can't skip or miss doses since suddenly stopping Neurontin (Gabapentin) can cause seizures. This is even more likely if you drink alcohol, so it might not be the best medication for heavy drinkers.
            No specific alcohol-related info.
            Food
            • Take the extended-release tablet with food.
            No specific food-related info.
            Kidneys and liver
            No specific kidneys and liver-related info.No specific kidneys and liver-related info.
            Sex
            No specific sex-related info.No specific sex-related info.
            Sleep
            • Neurontin (Gabapentin) is likely to cause some side effects, including memory problems, drowsiness, dizziness, or confusion.
            No specific sleep-related info.
            Weight
            No specific weight-related info.
            • Cases of heart failure due to taking Inderal (Propranolol) have been reported. Tell your doctor if you noticed increased swelling around your legs or ankles, sudden weight gain or sudden shortness of breath as these may be symptoms of heart failure.
            Upsides and benefits
            NeurontinPropranolol
            • Originally used to treat epilepsy (partial seizures), but now it primarily treats neuropathic pain that's caused by nerve stimulation or damage.
            • Studies show it's most effective for nerve pain from diabetes, shingles, and fibromyalgia (a painful muscle condition).
            • It's available as a generic, so it's less expensive than similar medications.
            • A first-choice treatment to prevent chest pain (angina).
            • A first-choice treatment for heart failure, heart attack, heart valve disorders, and abnormal heart rhythm.
            • Also treats and prevents many non-heart problems, such as tremors, anxiety, migraines, and liver disease symptoms.
            Downsides and risks
            NeurontinPropranolol
            • Neurontin (Gabapentin) is likely to cause some side effects, including memory problems, drowsiness, dizziness, or confusion.
            • You can't skip or miss doses since suddenly stopping Neurontin (Gabapentin) can cause seizures. This is even more likely if you drink alcohol, so it might not be the best medication for heavy drinkers.
            • Taking a beta blocker might make you feel more tired or out of breath during exercise or normal daily routines. This gets better for most people, but for some might not go away.
            • Has more side effects than some beta blockers because it crosses into the brain and central nervous system.
            • Not a first-choice treatment for high blood pressure according to the latest guidelines, except if you have heart failure or heart disease. As a second choice, your doctor might add it to medicines you're already taking if your blood pressure is still too high.
            • Can hide symptoms of low blood sugar if you're diabetic.
            • You can't miss doses. Stopping Propranolol suddenly can cause your blood pressure to go up suddenly, which raises the risk of heart attack and stroke.
            Tips from our pharmacists for people taking the medication
            NeurontinPropranolol
            • Side effects are common, but usually manageable.
            • Don't drive while taking Neurontin (Gabapentin) until you know how the medication affects you.
            • Neurontin and generic forms of Gabapentin have the same ingredients as Gralise and Horizant, but are dosed differently. Make sure you know which form you're taking since they are used for different purposes.
            • Take the extended-release tablet with food.
            • Stop taking Neurontin (Gabapentin) slowly over at least one week to avoid getting withdrawal symptoms.
            • Can cause dizziness in the first few days.
            • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
            • Can cause insomnia and fatigue.
            • Can hide symptoms of low blood sugar. Be careful if you're diabetic.
            • Don't stop taking this medicine suddenly.
            Learn more
            More about NeurontinSide effectsReviews & ratingsAlternativesFDA package insert
            More about PropranololSide effectsReviews & ratingsAlternativesFDA package insert