Compare Neurontin vs. Remeron

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Neurontin
(Gabapentin)

Remeron
(mirtazapine)

Treats tingling and burning nerve pain. Neurontin (Gabapentin) is an old seizure disorder medicine that's now used to treat nerve-related pain caused by different conditions.Improves mood. Remeron (mirtazapine) improves your mood and helps you sleep better, but can cause more weight gain than any other antidepressant.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.56Neurontin
Reviews for Neurontin
57%
of people (All ages) say Neurontin is worth it
40%
say it works well
19%
say it's a big hassle
620 reviews
Have you used Neurontin (Gabapentin)?
Worth itNot sureNot worth it
Reviews for Remeron
45%
+12% better vs. Neurontin
39%
+1% better vs. Neurontin
26%
+7% better vs. Neurontin
152 reviews
Have you used Remeron (mirtazapine)?
Worth itNot sureNot worth it
Side effects
NeurontinRemeron
  • Flatulence 1%
  • Thinking abnormal 2%
  • Amblyopia 2%
  • Accidental injury 2%
  • Constipation 2%
  • Vomiting 2%
  • Ataxia 3%
More Neurontin side effects »
  • Back pain 1%
  • Swelling in limbs 1%
  • Muscle pain 1%
  • Tremor 1%
  • Confusion 2%
  • Urinary frequency 1%
  • Abnormal thinking 2%
  • Abnormal dreams 3%
  • Flu syndrome 2%
  • Dizziness 4%
More Remeron side effects »
How it works
NeurontinRemeron
Neurontin (Gabapentin) is an antiepileptic and nerve pain reliever. Researchers don't know exactly how it works, but it has a similar structure to GABA, a neurotransmitter that calms nerves in the brain and spinal cord.Remeron (mirtazapine) is an atypical antidepressant. It stimulates your body to make certain chemicals in the brain, such as serotonin and norepinephrine, which regulate mood.
Type of medication
NeurontinRemeron
Prescription onlyLower-cost generic availablePrescription onlyLower-cost generic available
Available as
NeurontinRemeron
  • Pill
  • Oral solution
  • Pill
  • Dissolving tablet
Used for
NeurontinRemeron
Risk factors for serious side effects
NeurontinRemeron
  • Children ages 3 to 12
  • Taking with alcohol or drugs
  • Stopping Neurontin (Gabapentin) suddenly
Detailed Neurontin (Gabapentin) risks & warnings »
  • Age 24 years or younger
  • Using other medications that affect serotonin
  • History of heart problems
  • History of liver problems
  • Higher dose
Detailed Remeron (mirtazapine) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Interactions
NeurontinRemeron
No interactions related info.
  • Prescription medications can interact with Remeron (mirtazapine). Let your doctor or pharmacist know if you're on prescription medications currently or within the past 14 days.
Food
NeurontinRemeron
  • Take the extended-release tablet with food.
No food related info.
Pain
NeurontinRemeron
  • Studies show it's most effective for nerve pain from diabetes, shingles, and fibromyalgia (a painful muscle condition).
No pain related info.
Sleep
NeurontinRemeron
  • Neurontin (Gabapentin) is likely to cause some side effects, including memory problems, drowsiness, dizziness, or confusion.
  • Remeron (mirtazapine) can make you sleepy. It is best to take at bedtime.
  • Can help you fall asleep if you have trouble sleeping.
  • Makes you more tired than other antidepressants.
Weight
NeurontinRemeron
No weight related info.
  • Remeron (mirtazapine) can raise your appetite and cause you to gain weight. Remeron (mirtazapine) can also raise your cholesterol.
  • Remeron (mirtazapine) can increase your appetite and cause to you to gain weight.
  • Good option if you are underweight or frail, because it can help you gain weight.
  • More likely to cause minor weight gain (1-5 pounds) and raise cholesterol than any other antidepressant.
Upsides and benefits
NeurontinRemeron
  • Originally used to treat epilepsy (partial seizures), but now it primarily treats neuropathic pain that's caused by nerve stimulation or damage.
  • Studies show it's most effective for nerve pain from diabetes, shingles, and fibromyalgia (a painful muscle condition).
  • It's available as a generic, so it's less expensive than similar medications.
  • Effective at relieving some depression symptoms.
  • Starts to work more quickly than most antidepressants.
  • Can help you fall asleep if you have trouble sleeping.
  • Can also help relieve anxiety.
  • Good option if you are underweight or frail, because it can help you gain weight.
  • Available as a generic.
Downsides and risks
NeurontinRemeron
  • Neurontin (Gabapentin) is likely to cause some side effects, including memory problems, drowsiness, dizziness, or confusion.
  • You can't skip or miss doses since suddenly stopping Neurontin (Gabapentin) can cause seizures. This is even more likely if you drink alcohol, so it might not be the best medication for heavy drinkers.
  • Makes you more tired than other antidepressants.
  • More likely to cause minor weight gain (1-5 pounds) and raise cholesterol than any other antidepressant.
Tips from our pharmacists for people taking the medication
NeurontinRemeron
  • Side effects are common, but usually manageable.
  • Don't drive while taking Neurontin (Gabapentin) until you know how the medication affects you.
  • Neurontin and generic forms of Gabapentin have the same ingredients as Gralise and Horizant, but are dosed differently. Make sure you know which form you're taking since they are used for different purposes.
  • Take the extended-release tablet with food.
  • Stop taking Neurontin (Gabapentin) slowly over at least one week to avoid getting withdrawal symptoms.
  • Remeron (mirtazapine) can make you sleepy. It is best to take at bedtime.
  • Remeron (mirtazapine) can increase your appetite and cause to you to gain weight.
  • You should not abruptly stop Remeron (mirtazapine) as this could cause serious side effects.
  • Prescription medications can interact with Remeron (mirtazapine). Let your doctor or pharmacist know if you're on prescription medications currently or within the past 14 days.
  • Remeron (mirtazapine) should be protected from light. Keep it in it's original package until ready to use.
  • Remeron (mirtazapine) can cause dry mouth. Try using sugar-free gum or candy to help with dry mouth.
Learn more
More about NeurontinSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Neurontin (Gabapentin)?
Worth itNot sureNot worth it
More about RemeronSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Remeron (mirtazapine)?
Worth itNot sureNot worth it