Compare Neurontin vs. Remeron

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Neurontin
(Gabapentin)

Remeron
(Mirtazapine)

Treats tingling and burning nerve pain. Neurontin (Gabapentin) is an old seizure disorder medicine that's now used to treat nerve-related pain caused by different conditions.Improves mood. Remeron (Mirtazapine) is okay for treating depression and good for sleep. More likely to cause weight gain than any other antidepressant.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
4.542087542087542Neurontin
Reviews for Neurontin (Gabapentin)
57%
of people say Neurontin (Gabapentin) is worth it
39%
say it works well
19%
say it's a big hassle
Reviews for Remeron (Mirtazapine)
47%
10% vs. Neurontin (Gabapentin)
42%
+3% vs. Neurontin (Gabapentin)
26%
7% vs. Neurontin (Gabapentin)
Side effects
NeurontinRemeron
  • Dizziness 21%
  • Drowsiness 16%
  • Lack of muscle coordination 7%
  • Leg or ankle swelling 6%
  • Fatigue 6%
  • Hostility 5%
  • Involuntary eye movement 4%
  • Double vision 4%
  • Tremor 4%
  • Dry mouth 4%
More Neurontin side effects »
  • Drowsiness 36%
  • Increased appetite 15%
  • Dry mouth 10%
  • Weight gain 10%
  • Constipation 6%
  • Dizziness 4%
  • Muscle weakness 3%
  • Abnormal dreams 3%
  • Flu syndrome 2%
  • Thinking abnormal 2%
More Remeron side effects »
How it works
NeurontinRemeron
Neurontin (Gabapentin) is an antiepileptic and nerve pain reliever. Researchers don't know exactly how it works, but it has a similar structure to GABA, a neurotransmitter that calms nerves in the brain and spinal cord.Remeron (Mirtazapine) is an atypical antidepressant. It stimulates your body to make certain chemicals in the brain, such as serotonin and norepinephrine, which regulate mood.
Type of medication
NeurontinRemeron
Anticonvulsant
GABA analog
Prescription only
Antidepressant
Noradrenergic and specific serotonergic antidepressant
Prescription only
Available as
NeurontinRemeron
  • Pill
  • Oral solution
  • Pill
  • Dissolving tablet
Used for (click to learn more)
NeurontinRemeron
How well it works for depression
The free Iodine Start program helps people track how well they are improving, and find the right antidepressant faster.
The free Iodine Start program (personal reports and coaching) is currently only for antidepressants. For now, you can read our pharmacist info about this medication.Learn more about Neurontin (Gabapentin)

After 4 weeks using Start and Remeron (Mirtazapine), here’s how much better people feel.

Risk factors for serious side effects
NeurontinRemeron
    • Children ages 3 to 12
      • Taking with alcohol or drugs
      • Stopping Neurontin (Gabapentin) suddenly
      Detailed Neurontin (Gabapentin) risks & warnings »
      • Age 24 years or younger
      • Using other medications that affect serotonin
      • History of heart problems
      • History of liver problems
      • Higher dose
      • Alcohol
      • Taking other medicines that make you less alert
          Detailed Remeron (Mirtazapine) risks & warnings »
          Pregnancy category
          NeurontinRemeron
          CFDA pregnancy category (Weigh risks vs. benefits)

          Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          See the FDA package insert
          CFDA pregnancy category (Weigh risks vs. benefits)

          Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          See the FDA package insert
          Alcohol
          • You can't skip or miss doses since suddenly stopping Neurontin (Gabapentin) can cause seizures. This is even more likely if you drink alcohol, so it might not be the best medication for heavy drinkers.
          No specific alcohol-related info.
          Food
          • Take the extended-release tablet with food.
          No specific food-related info.
          Kidneys and liver
          No specific kidneys and liver-related info.No specific kidneys and liver-related info.
          Sex
          No specific sex-related info.No specific sex-related info.
          Sleep
          • Neurontin (Gabapentin) is likely to cause some side effects, including memory problems, drowsiness, dizziness, or confusion.
          No specific sleep-related info.
          Weight
          No specific weight-related info.
          • More likely to cause minor weight gain (1 to 5 pounds) and raise cholesterol than any other antidepressant.
          • Good option for people who are underweight or frail, because it can help you gain weight.
          • Can increase appetite and weight.
          • Remeron (Mirtazapine) can increase appetite and cause you to gain weight.
          Upsides and benefits
          NeurontinRemeron
          • Originally used to treat epilepsy (partial seizures), but now it primarily treats neuropathic pain that's caused by nerve stimulation or damage.
          • Studies show it's most effective for nerve pain from diabetes, shingles, and fibromyalgia (a painful muscle condition).
          • It's available as a generic, so it's less expensive than similar medications.
          • Effective at relieving some depression symptoms.
          • Starts to work more quickly than most antidepressants.
          • Might be a good option for people who have insomnia with their depression, because it can make you very sleepy.
          • Good option for people who are underweight or frail, because it can help you gain weight.
          • Six out of ten people who use an antidepressant for the first time find that it works for them.
          Downsides and risks
          NeurontinRemeron
          • Neurontin (Gabapentin) is likely to cause some side effects, including memory problems, drowsiness, dizziness, or confusion.
          • You can't skip or miss doses since suddenly stopping Neurontin (Gabapentin) can cause seizures. This is even more likely if you drink alcohol, so it might not be the best medication for heavy drinkers.
          • Not as effective as other medications for depression.
          • More sedating than other antidepressants.
          • More likely to cause minor weight gain (1 to 5 pounds) and raise cholesterol than any other antidepressant.
          • Like most antidepressants, can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
          • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
          Tips from our pharmacists for people taking the medication
          NeurontinRemeron
          • Side effects are common, but usually manageable.
          • Don't drive while taking Neurontin (Gabapentin) until you know how the medication affects you.
          • Neurontin and generic forms of Gabapentin have the same ingredients as Gralise and Horizant, but are dosed differently. Make sure you know which form you're taking since they are used for different purposes.
          • Take the extended-release tablet with food.
          • Stop taking Neurontin (Gabapentin) slowly over at least one week to avoid getting withdrawal symptoms.
          • Makes you sleepy. Take at bedtime.
          • Can increase appetite and weight.
          • Takes 8 to 12 weeks to see full effects on mood.
          • Stop taking slowly to avoid withdrawal symptoms.
          • Tell your doctor if you notice sudden mood changes or unusual thoughts.
          Learn more
          More about NeurontinSide effectsReviews & ratingsAlternativesFDA package insert
          More about RemeronSide effectsReviews & ratingsAlternativesFDA package insert