Compare Neurontin vs. Seroquel

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Neurontin (gabapentin)

Prescription only

Seroquel (quetiapine)

Prescription only
Treats tingling and burning nerve pain.

Neurontin (gabapentin) is an old seizure disorder medicine that is now used to treat nerve-related pain caused by different conditions.

3.4/ 5 average rating with 620 reviewsforNeurontin
Helps control your thoughts and mood.

Seroquel (quetiapine) is a effective at treating schizophrenia, mania, and depression but it can cause weight gain and high blood glucose levels.

3.7/ 5 average rating with 250 reviewsforSeroquel
Upsides
  • Originally used to treat epilepsy (partial seizures), but now it primarily treats neuropathic pain that's caused by nerve stimulation or damage.
  • Studies show it's most effective for nerve pain from diabetes, shingles, and fibromyalgia (a painful muscle condition).
  • It's available as a generic, so it's less expensive than similar medications.
  • Seroquel (quetiapine) is effective at relieving psychotic symptoms and manic episodes.
  • Seroquel (quetiapine) has fewer side effects than most antipsychotic medications.
  • Seroquel (quetiapine) is less likely to cause heart problems compared to some other antipsychotics.
  • Seroquel (quetiapine) is also the least likely to cause Extrapyramidal Symptoms (EPS) – a movement disorder that causes stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements.
Downsides
  • Neurontin (gabapentin) can cause some side effects, including memory problems, drowsiness, dizziness, or confusion. There is a higher risk for these side effects if you drink alcohol, so it might not be the best medication for heavy drinkers.
  • You can't skip or miss doses since suddenly stopping Neurontin (gabapentin) can cause seizures.
  • Seroquel (quetiapine) has a moderate to high risk of weight gain, elevated cholesterol and/or blood sugar compared to other antipsychotics.
  • You might need routine blood tests to check how Seroquel (quetiapine) is affecting your body.
Used for
Dosage forms
  • Pill
  • Oral solution
  • Extended release
  • Pill
  • Extended release
Price
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Reviews
620 reviews so far
57%
saidit'sworth it
40%
saiditworked well
19%
saidit'sa big hassle

Have you used Neurontin (gabapentin)?

Leave a review
250 reviews so far
56%
saidit'sworth it
50%
saiditworked well
27%
saidit'sa big hassle

Have you used Seroquel (quetiapine)?

Leave a review
Side effects
The Neurontin (gabapentin) FDA package insert doesn’t have numbers about how common side effects are.
36possible side effects
  • Drowsiness
    34%
  • Dry mouth
    19%
  • Headache
    17%
  • Weakness
    10%
  • Constipation
    10%
  • Dizziness
    9%
  • Tremor
    8%
  • Stomach pain
    7%
  • Low blood pressure
    7%
  • Agitation
    6%
  • Weight gain
    6%
  • Sore throat
    6%
  • Back pain
    5%
  • Stiffness/difficulty moving
    4%
  • Hay fever
    4%
  • Swelling in the limbs
    4%
  • Twitching
    4%
  • Indigestion
    4%
  • Depression
    3%
  • Lazy eye
    3%
  • Speech disorder
    3%
  • Altered hormone levels
    3%
  • Heaviness
    2%
  • Infection
    2%
  • Fever
    2%
  • High blood pressure
    2%
  • Increased heart rate
    2%
  • Increased appetite
    2%
  • Hypothyroidism
    2%
  • Incoordination
    2%
  • Abnormal thinking
    2%
  • Anxiety
    2%
  • Loss of control of movements
    2%
  • Sinus infection
    2%
  • Sweating
    2%
  • Urinary Tract Infection
    2%
See more detailed side effects
Risks and risk factors
  • Suicidal thoughts or behavior
  • Neurologic and psychiatric side effects (children)
    • Children ages 3 to 12
  • Serious allergic reaction and multiple organ problems
  • Driving impairment
    • Taking Neurontin (gabapentin) with alcohol
    • Taking other medicines that cause dizziness and/or drowsiness
  • Withdrawal seizures
    • Stopping Neurontin (gabapentin) suddenly
See more detailed risks and warnings
  • Higher risk of death
    • Elderly patients with dementia-related psychosis
  • Suicidal thoughts or behavior
    • Children, adolescents, and young adults (<24 years old)
  • Neuroleptic malignant syndrome
  • Heart problems
    • History of heart problems
    • Drug interactions
  • Extrapyramidal Symptoms (EPS)
  • Metabolic changes (increased blood sugar, high cholesterol and weight gain)
    • People with diabetes
    • People with high cholesterol
See more detailed risks and warnings