Compare Neurontin vs. Topamax

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Neurontin
(Gabapentin)

Qudexy Xr
(Topiramate)

Treats tingling and burning nerve pain. Neurontin (Gabapentin) is an old seizure disorder medicine that's now used to treat nerve-related pain caused by different conditions.Prevents seizures and migraine headaches. Qudexy Xr (Topiramate) is useful for preventing seizures and migraines, and doesn't require blood tests while you're on it.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
4.542087542087542Neurontin
Reviews for Neurontin (Gabapentin)
57%
of people say Neurontin (Gabapentin) is worth it
39%
say it works well
19%
say it's a big hassle
Reviews for Qudexy Xr (Topiramate)
54%
3% vs. Neurontin (Gabapentin)
52%
+13% vs. Neurontin (Gabapentin)
33%
14% vs. Neurontin (Gabapentin)
Side effects
NeurontinTopamax
  • Dizziness 21%
  • Drowsiness 16%
  • Lack of muscle coordination 7%
  • Leg or ankle swelling 6%
  • Fatigue 6%
  • Hostility 5%
  • Involuntary eye movement 4%
  • Double vision 4%
  • Tremor 4%
  • Dry mouth 4%
More Neurontin side effects »
  • Tingling sensation 45%
  • Slowed-down thinking and movements 19%
  • Dizziness 17%
  • Drowsiness 17%
  • Fatigue 17%
  • Change in taste 14%
  • Difficulty with concentration/attention 13%
  • Nervousness 12%
  • Difficulty with memory 11%
  • Vision abnormal 11%
More Topamax side effects »
How it works
NeurontinTopamax
Neurontin (Gabapentin) is an antiepileptic and nerve pain reliever. Researchers don't know exactly how it works, but it has a similar structure to GABA, a neurotransmitter that calms nerves in the brain and spinal cord.Qudexy Xr (Topiramate) is an antiepileptic. Researchers don't know exactly how it works, but it seems to affect multiple parts of the brain to control seizures and migraines.
Type of medication
NeurontinTopamax
Anticonvulsant
GABA analog
Prescription only
AnticonvulsantPrescription only
Available as
NeurontinTopamax
  • Pill
  • Oral solution
  • Pill
  • Extended release capsule
Used for (click to learn more)
NeurontinTopamax
Risk factors for serious side effects
NeurontinTopamax
    • Children ages 3 to 12
      • Taking with alcohol or drugs
      • Stopping Neurontin (Gabapentin) suddenly
      Detailed Neurontin (Gabapentin) risks & warnings »
      • History of depression
        • Children
        • History of metabolic disorders
        • People also taking Depakote
        • Low-carb diet
        • Dehydration
        • Drug interactions
          • Stopping Qudexy Xr (Topiramate) suddenly
          Detailed Qudexy Xr (Topiramate) risks & warnings »
          Pregnancy category
          NeurontinTopamax
          Alcohol
          • You can't skip or miss doses since suddenly stopping Neurontin (Gabapentin) can cause seizures. This is even more likely if you drink alcohol, so it might not be the best medication for heavy drinkers.
          No specific alcohol-related info.
          Food
          • Take the extended-release tablet with food.
          No specific food-related info.
          Kidneys and liver
          No specific kidneys and liver-related info.
          • A few people will get kidney stones.
          • Qudexy Xr (Topiramate) may increase your risk for kidney stones. Stay well-hydrated to lower your risk.
          Sex
          No specific sex-related info.No specific sex-related info.
          Sleep
          • Neurontin (Gabapentin) is likely to cause some side effects, including memory problems, drowsiness, dizziness, or confusion.
          No specific sleep-related info.
          Weight
          No specific weight-related info.
          • Can cause sleepiness, speech problems, tingling sensations, and weight loss.
          Upsides and benefits
          NeurontinTopamax
          • Originally used to treat epilepsy (partial seizures), but now it primarily treats neuropathic pain that's caused by nerve stimulation or damage.
          • Studies show it's most effective for nerve pain from diabetes, shingles, and fibromyalgia (a painful muscle condition).
          • It's available as a generic, so it's less expensive than similar medications.
          • Used on its own or with other antiepileptic medicines to lower the frequency of seizures, especially for people with tonic-clonic or partial seizures, or Lennox-Gestaut syndrome.
          • Helpful in preventing frequent migraine headaches.
          • Doesn't need routine blood tests.
          Downsides and risks
          NeurontinTopamax
          • Neurontin (Gabapentin) is likely to cause some side effects, including memory problems, drowsiness, dizziness, or confusion.
          • You can't skip or miss doses since suddenly stopping Neurontin (Gabapentin) can cause seizures. This is even more likely if you drink alcohol, so it might not be the best medication for heavy drinkers.
          • Can cause sleepiness, speech problems, tingling sensations, and weight loss.
          • A few people will get kidney stones.
          • Not safe to use if you're pregnant.
          Tips from our pharmacists for people taking the medication
          NeurontinTopamax
          • Side effects are common, but usually manageable.
          • Don't drive while taking Neurontin (Gabapentin) until you know how the medication affects you.
          • Neurontin and generic forms of Gabapentin have the same ingredients as Gralise and Horizant, but are dosed differently. Make sure you know which form you're taking since they are used for different purposes.
          • Take the extended-release tablet with food.
          • Stop taking Neurontin (Gabapentin) slowly over at least one week to avoid getting withdrawal symptoms.
          • For the first week, avoid activities that require you to be alert.
          • Don't use if pregnant.
          • Can cause tingling skin sensations and reduced appetite.
          • Report any confusion, decreased sweating, fever, or changes in behavior or vision.
          • Takes 3 to 4 weeks to feel full effects on mood.
          Learn more
          More about NeurontinSide effectsReviews & ratingsAlternativesFDA package insert
          More about TopamaxSide effectsReviews & ratingsAlternativesFDA package insert