Compare Neurontin vs. Zoloft

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Neurontin
(gabapentin)

Zoloft
(sertraline)

Treats tingling and burning nerve pain. Neurontin (Gabapentin) is an old seizure disorder medicine that's now used to treat nerve-related pain caused by different conditions.Improves mood and helps you relax. Zoloft (Sertraline) is good for treating depression and anxiety. It's more likely to cause insomnia and diarrhea than other antidepressants.
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Coupons for Neurontin
Best available price for 90 (300mg) capsules of gabapentin
Coupons for Zoloft
Best available price for 30 (100mg) tablets of zoloft
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.56Neurontin
Reviews for Neurontin
57%
of people (All ages) say Neurontin is worth it
40%
say it works well
19%
say it's a big hassle
620 reviews
Have you used Neurontin (gabapentin)?
Worth itNot sureNot worth it
Reviews for Zoloft
59%
-2% worse vs. Neurontin
41%
-1% worse vs. Neurontin
15%
-4% worse vs. Neurontin
1472 reviews
Have you used Zoloft (sertraline)?
Worth itNot sureNot worth it
Side effects
NeurontinZoloft
  • Dizziness 21%
  • Drowsiness 16%
  • Leg or ankle swelling 6%
  • Muscle weakness 1%
  • Diarrhea 2%
  • Infection 2%
  • Dry mouth 3%
  • Constipation 2%
  • Accidental injury 2%
  • Vomiting 2%
More Neurontin side effects »
  • Nausea 14%
  • Diarrhea/loose stools 9%
  • Sleep difficulty 7%
  • Mouth dry 7%
  • Drowsiness 7%
  • Dizziness 5%
  • Tremor 8%
  • Fatigue 3%
  • Sweating increased 5%
  • Constipation 2%
More Zoloft side effects »
How it works
NeurontinZoloft
Neurontin (Gabapentin) is an antiepileptic and nerve pain reliever. Researchers don't know exactly how it works, but it has a similar structure to GABA, a neurotransmitter that calms nerves in the brain and spinal cord.Zoloft (Sertraline) is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It increases the activity of serotonin in the brain, which regulates mood.
Type of medication
NeurontinZoloft
Prescription onlyPrescription only
Available as
NeurontinZoloft
  • Pill
  • Oral solution
  • Pill
  • Liquid
Used for
NeurontinZoloft
Risk factors for serious side effects
NeurontinZoloft
  • Children ages 3 to 12
  • Taking with alcohol or drugs
  • Stopping Neurontin (Gabapentin) suddenly
Detailed Neurontin (gabapentin) risks & warnings »
  • Under 24 years old
  • Interactions with other medications
  • Stopping Zoloft (Sertraline) suddenly
  • Taking with blood-thinning drugs
  • Elderly
Detailed Zoloft (sertraline) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Interactions
NeurontinZoloft
No interactions related info.
  • It interacts with St. John's Wort and Tryptophan.
Food
NeurontinZoloft
  • Take the extended-release tablet with food.
No food related info.
Pain
NeurontinZoloft
  • Studies show it's most effective for nerve pain from diabetes, shingles, and fibromyalgia (a painful muscle condition).
No pain related info.
Sex
NeurontinZoloft
No sex related info.
  • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
Sleep
NeurontinZoloft
  • Neurontin (Gabapentin) is likely to cause some side effects, including memory problems, drowsiness, dizziness, or confusion.
  • Zoloft (Sertraline) may increase the risk of low sodium levels in the blood (hyponatremia). Watch out for symptoms including headache, difficulty concentrating, memory problems, confusion, weakness, and unsteadiness, which may lead to falls. Talk to a doctor right away before developing more serious symptoms, such as hallucination, fainting, coma, and death.
  • Causes less drowsiness than other antidepressants.
Upsides and benefits
NeurontinZoloft
  • Originally used to treat epilepsy (partial seizures), but now it primarily treats neuropathic pain that's caused by nerve stimulation or damage.
  • Studies show it's most effective for nerve pain from diabetes, shingles, and fibromyalgia (a painful muscle condition).
  • It's available as a generic, so it's less expensive than similar medications.
  • Effective at lowering symptoms and relapse rates of depression and anxiety disorders.
  • Causes less drowsiness than other antidepressants.
  • Six out of ten people who use an antidepressant for the first time find that it works for them.
Downsides and risks
NeurontinZoloft
  • Neurontin (Gabapentin) is likely to cause some side effects, including memory problems, drowsiness, dizziness, or confusion.
  • You can't skip or miss doses since suddenly stopping Neurontin (Gabapentin) can cause seizures. This is even more likely if you drink alcohol, so it might not be the best medication for heavy drinkers.
  • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
  • More likely to cause diarrhea than other antidepressants.
  • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than 24.
  • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
Tips from our pharmacists for people taking the medication
NeurontinZoloft
  • Side effects are common, but usually manageable.
  • Don't drive while taking Neurontin (Gabapentin) until you know how the medication affects you.
  • Neurontin and generic forms of Gabapentin have the same ingredients as Gralise and Horizant, but are dosed differently. Make sure you know which form you're taking since they are used for different purposes.
  • Take the extended-release tablet with food.
  • Stop taking Neurontin (Gabapentin) slowly over at least one week to avoid getting withdrawal symptoms.
  • Takes about 8 to 12 weeks to see the medication's full effects on your mood.
  • It interacts with St. John's Wort and Tryptophan.
  • Stop taking it slowly to avoid getting withdrawal symptoms.
  • Tell your doctor if you notice sudden mood changes or unusual thoughts.
Learn more
More about NeurontinSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Neurontin (gabapentin)?
Worth itNot sureNot worth it
More about ZoloftSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Zoloft (sertraline)?
Worth itNot sureNot worth it