Compare Nexium vs. Alka-Seltzer

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Nexium (esomeprazole)

Over-the-counter
Treats heartburn and stomach ulcers.

Nexium (esomeprazole) gives you long-lasting heartburn relief but has some risks if used long term.

5.5/ 7 average rating with 1239 reviewsforNexium
Relieves heartburn, headache, and body pains.

Alka-Seltzer Original (Aspirin / Citric Acid / Sodium Bicarbonate) gives quick relief for headache, body pains, and upset tummies, but might be hard to swallow if you don't like the taste or fizz.

5.4/ 7 average rating with 1055 reviewsforAlka-Seltzer
Upsides
  • Most people can take Nexium (esomeprazole) without any noticeable day-to-day side effects.
  • Nexium (esomeprazole) lasts longer than other types of antacids (like Zantac, Pepcid, or Tums), and you only need to take it once a day.
  • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need quicker relief.
  • Nexium (esomeprazole) is inexpensive, with over-the-counter and generic options.
  • Coupons are available for the brand name - speak to your doctor or pharmacist.
  • The packet form is a good option if you have trouble swallowing pills.They can be mixed with water for easier swallowing.
  • Works great if you have an upset stomach and a headache or body pain at the same time.
  • Works really fast.
  • Available over the counter without a prescription.
  • Cheap.
Downsides
  • Doesn't start working right away like antacids (Tums, Rolaids, or Maalox).
  • It can take several days or weeks to start feeling benefits.
  • May not be the best choice for patients 65 years of age and older due to risk of bone fractures and severe diarrhea.
  • Doesn't last very long.
  • Other antacids like Zantac (H2 blockers) and omeprazole (proton pump inhibitors) can work better and last longer.
  • Because it has aspirin in it, it increases the risk of bleeding, especially if you take any other blood thinning medicine.
  • Can't be used by people with allergy to aspirin.
  • You may not like the taste or fizz.
Used for
  • GERD
  • H. Pylori bacterial infection
  • Prevention and treatment of NSAID-induced gastric ulcers
Dosage forms
  • Pill
  • Injection
  • Packet
  • Chewable tablet
  • Effervescent tablet
Price
Lowest price near you
$32.5
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Reviews
1239 
75%
think this treatment is worth it
59%
think this treatment works well
11%
think this treatment is a hassle

Have you used Nexium (esomeprazole)?

Leave a review
1055 
81%
think this treatment is worth it
52%
think this treatment works well
8%
think this treatment is a hassle

Have you used Alka-Seltzer Original (Aspirin / Citric Acid / Sodium Bicarbonate)?

Leave a review
Side effects
The Nexium (esomeprazole) FDA package insert doesn’t have numbers about how common side effects are.
The Alka-Seltzer Original (Aspirin / Citric Acid / Sodium Bicarbonate) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Severe diarrhea

    Being treated at a hospital

  • Bone fractures

    High dose Nexium (esomeprazole)

    ...and 3 more risk factors

See more detailed risks and warnings
  • High blood sodium levels

    Current kidney disease

    ...and 2 more risk factors

  • May worsen heart or kidney problems

    Congestive heart failure (CHF)

    ...and 3 more risk factors

  • Brain damage or death from Reye's Syndrome

    Children 18 years or younger recovering from viral infections

  • Stomach Bleeding

    History of stomach bleeding or ulcers

    ...and 3 more risk factors

  • Serious allergic reactions

    Asthma

    ...and 4 more risk factors

See more detailed risks and warnings