Compare Nexium vs. Maalox

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Nexium
(esomeprazole)

Maalox
(aluminum / magnesium / simethicone)

Treats heartburn and stomach ulcers. Nexium (esomeprazole) gives you long-lasting heartburn relief but has some risks if used long term.Relieves heartburn and indigestion. Maalox (aluminum / magnesium / simethicone) gives quick relief for heartburn, gas, and bloating, but it may not be as effective or last as long as other antacids.
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.45Nexium
Reviews for Nexium
75%
of people (All ages) say Nexium is worth it
59%
say it works well
11%
say it's a big hassle
1239 reviews
Have you used Nexium (esomeprazole)?
Worth itNot sureNot worth it
Reviews for Maalox
69%
+6% better vs. Nexium
30%
+29% better vs. Nexium
9%
-2% worse vs. Nexium
213 reviews
Have you used Maalox (aluminum / magnesium / simethicone)?
Worth itNot sureNot worth it
Side effects
NexiumMaalox

The Nexium FDA package insert doesn’t have numbers about how common side effects are.

More about Nexium side effects »

The Maalox FDA package insert doesn’t have numbers about how common side effects are.

More about Maalox side effects »
How it works
NexiumMaalox
Nexium (esomeprazole) is a proton pump inhibitor (PPI). It treats heartburn and heals ulcers by lowering the amount of acid in your stomach.Maalox (aluminum / magnesium / simethicone) is a combination medicine for heartburn and indigestion. Aluminum and magnesium are antacids that treat heartburn and indigestion. Simethicone relieves gas and bloating.
Type of medication
NexiumMaalox
Over-the-counterOver-the-counter
Available as
NexiumMaalox
  • Pill
  • Injection
  • Packet
  • Chewable tablet
  • Liquid
Used for
NexiumMaalox
  • GERD
  • H Pylori Bacterial Infection
Risk factors for serious side effects
NexiumMaalox
  • Being treated at a hospital
  • High dose Nexium (esomeprazole)
  • Long-term treatment with Nexium (esomeprazole)
  • Low bone mineral density
  • Aged 65 years or older
Detailed Nexium (esomeprazole) risks & warnings »
  • Kidney problems
  • Taking more than the recommended daily maximum
Detailed Maalox (aluminum / magnesium / simethicone) risks & warnings »
Pregnancy
Interactions
NexiumMaalox
  • Since some prescription drugs can interact with Nexium (esomeprazole), talk to your doctor about all the medicines that you're taking.
No interactions related info.
Food
NexiumMaalox
No food related info.
  • Talk to your doctor or pharmacist about foods to avoid that can help prevent heartburn.
Kidneys and liver
NexiumMaalox
  • Nexium (esomeprazole) can cause acute kidney damage that can occur at any time during treatment. If you notice blood in the urine, changes in urine output, swelling of the body, weight gain, fever, or confusion, stop taking Nexium (esomeprazole) and speak to your doctor immediately.
  • Maalox (aluminum / magnesium / simethicone) contains aluminum and magnesium that can build up in your kidneys if you have kidney problems which can be dangerous. Talk to your doctor or pharmacist before taking Maalox (aluminum / magnesium / simethicone) to see if it is right for you. Don't take more than the maximum amount per day as shown on the label.
Upsides and benefits
NexiumMaalox
  • Most people can take Nexium (esomeprazole) without any noticeable day-to-day side effects.
  • Nexium (esomeprazole) lasts longer than other types of antacids (like Zantac, Pepcid, or Tums), and you only need to take it once a day.
  • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need quicker relief.
  • Nexium (esomeprazole) is inexpensive, with over-the-counter and generic options.
  • Coupons are available for the brand name - speak to your doctor or pharmacist.
  • The packet form is a good option if you have trouble swallowing pills.They can be mixed with water for easier swallowing.
  • Works quickly.
  • Inexpensive and available over-the-counter.
  • Is one of the first choice medications for heartburn relief if you are pregnant.
Downsides and risks
NexiumMaalox
  • Doesn't start working right away like antacids (Tums, Rolaids, or Maalox).
  • It can take several days or weeks to start feeling benefits.
  • May not be the best choice for patients 65 years of age and older due to risk of bone fractures and severe diarrhea.
  • Doesn't last very long. Talk to your doctor or pharmacist if you need longer lasting relief.
  • Is not a good option if you have frequent symptoms (more than 2 times a week). Talk to your doctor or pharmacist about stronger medications.
Tips from our pharmacists for people taking the medication
NexiumMaalox
  • Take Nexium (esomeprazole) with a full glass of water 1 hour before eating.
  • Starts working in as little as an hour.
  • It can take 1 to 4 days to take full effect.
  • Since some prescription drugs can interact with Nexium (esomeprazole), talk to your doctor about all the medicines that you're taking.
  • Do not take Nexium (esomeprazole) for more than 14 days, unless directed by your doctor. Speak to your doctor if your symptoms don't go away after 2 weeks.
  • Nexium (esomeprazole) capsules can be opened and sprinkled on 1 tablespoon of applesauce, cottage cheese, or yogurt. Swallow immediately after.
  • Starts working within minutes, and lasts for 1-2 hours.
  • If you are using the liquid product, shake well before using.
  • Don't take more than the recommended amount per day on the package. If you need to take this for more than 2 weeks, talk to your doctor.
  • People on a magnesium-restricted diet may need to avoid Maalox. Ask your doctor.
  • Talk to your doctor or pharmacist about foods to avoid that can help prevent heartburn.
  • Eating smaller portion sizes and not eating 3 hours before bedtime can help prevent heartburn.
Learn more
More about NexiumSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Nexium (esomeprazole)?
Worth itNot sureNot worth it
More about MaaloxSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Maalox (aluminum / magnesium / simethicone)?
Worth itNot sureNot worth it