Compare Nexium vs. Maalox

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Nexium (esomeprazole)

Over-the-counter
Treats heartburn and stomach ulcers.

Nexium (esomeprazole) gives you long-lasting heartburn relief but has some risks if used long term.

5.5/ 7 average rating with 1239 reviewsforNexium
Relieves heartburn and indigestion.

Maalox (aluminum / magnesium / simethicone) gives quick relief for heartburn, gas, and bloating, but it may not be as effective or last as long as other antacids.

4.6/ 7 average rating with 213 reviewsforMaalox
Upsides
  • Most people can take Nexium (esomeprazole) without any noticeable day-to-day side effects.
  • Nexium (esomeprazole) lasts longer than other types of antacids (like Zantac, Pepcid, or Tums), and you only need to take it once a day.
  • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need quicker relief.
  • Nexium (esomeprazole) is inexpensive, with over-the-counter and generic options.
  • Coupons are available for the brand name - speak to your doctor or pharmacist.
  • The packet form is a good option if you have trouble swallowing pills.They can be mixed with water for easier swallowing.
  • Works quickly.
  • Inexpensive and available over-the-counter.
  • Is one of the first choice medications for heartburn relief if you are pregnant.
Downsides
  • Doesn't start working right away like antacids (Tums, Rolaids, or Maalox).
  • It can take several days or weeks to start feeling benefits.
  • May not be the best choice for patients 65 years of age and older due to risk of bone fractures and severe diarrhea.
  • Doesn't last very long. Talk to your doctor or pharmacist if you need longer lasting relief.
  • Is not a good option if you have frequent symptoms (more than 2 times a week). Talk to your doctor or pharmacist about stronger medications.
Used for
  • GERD
  • H. Pylori bacterial infection
  • Prevention and treatment of NSAID-induced gastric ulcers
Dosage forms
  • Pill
  • Injection
  • Packet
  • Chewable tablet
  • Liquid
Price
Lowest price near you
$32.5
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Reviews
1239 
75%
think this treatment is worth it
59%
think this treatment works well
11%
think this treatment is a hassle

Have you used Nexium (esomeprazole)?

Leave a review
213 
69%
think this treatment is worth it
30%
think this treatment works well
9%
think this treatment is a hassle

Have you used Maalox (aluminum / magnesium / simethicone)?

Leave a review
Side effects
The Nexium (esomeprazole) FDA package insert doesn’t have numbers about how common side effects are.
The Maalox (aluminum / magnesium / simethicone) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Severe diarrhea

    Being treated at a hospital

  • Bone fractures

    High dose Nexium (esomeprazole)

    ...and 3 more risk factors

See more detailed risks and warnings
  • Aluminum and magnesium overdose

    Kidney problems

    ...and 1 more risk factors

See more detailed risks and warnings