Compare Nexium vs. Pantoprazole

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Nexium
(Esomeprazole)

Protonix
(Pantoprazole)

Treats heartburn and stomach ulcers. Nexium (Esomeprazole) gives you long-lasting heartburn relief. But this purple pill ain't cheap! The generic forms of alternative drugs work just as well, and are usually less expensive.Treats heartburn and stomach ulcers. Protonix (Pantoprazole) gives you long-lasting heartburn relief. Choose the cheapest proton pump inhibitor because they all work equally well for heartburn.
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.442903752039152Nexium
Reviews for Nexium (Esomeprazole)
75%
of people (All ages) say Nexium (Esomeprazole) is worth it
59%
say it works well
11%
say it's a big hassle
1226 reviews
Have you used Nexium (Esomeprazole)?
Worth itNot sureNot worth it
Reviews for Protonix (Pantoprazole)
69%
6% vs. Nexium (Esomeprazole)
51%
8% vs. Nexium (Esomeprazole)
13%
2% vs. Nexium (Esomeprazole)
551 reviews
Have you used Protonix (Pantoprazole)?
Worth itNot sureNot worth it
Side effects
NexiumPantoprazole

The Nexium FDA package insert doesn’t have numbers about how common side effects are.

More about Nexium side effects »

We haven’t found good data for Pantoprazole side effects.

FDA side effect reports for Pantoprazole »
How it works
NexiumPantoprazole
Nexium (Esomeprazole) is a proton pump inhibitor (PPI). It lowers the amount of acid in your stomach, treats heartburn, and heals ulcers.Protonix (Pantoprazole) is a proton pump inhibitor (PPI). It lowers the amount of acid in your stomach, treats heartburn, and heals ulcers.
Type of medication
NexiumPantoprazole
Acid reducer
Proton pump inhibitor
Prescription or OTC
Acid reducer
Proton pump inhibitor
Prescription only
Available as
NexiumPantoprazole
  • Extended release
  • Extended release
Used for (click to learn more)
NexiumPantoprazole
Risk factors for serious side effects
NexiumPantoprazole
    • Helicobacter pylori infection
    • Autoimmune disease
    • Being hospitalized
    • Antibiotic use
    • Osteoporosis
    • Age 50 or older
    • Using high medication doses
    • Long-term therapy (1 year or more)
    • Smoking
    • Use of other medications that weaken bones
      Detailed Nexium (Esomeprazole) risks & warnings »
        • Helicobacter pylori infection
        • Autoimmune disease
        • Osteoporosis
        • Age 50 or older
        • Using high medication doses
        • Long-term therapy (1 year or more)
        • Smoking
        • Use of other medications that weaken bones
            Detailed Protonix (Pantoprazole) risks & warnings »
            Pregnancy

            Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

            Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

            Interactions
            NexiumPantoprazole
            • Can interact with other drugs so be sure your doctor knows all the medicine you're taking before starting Nexium.
            • Avoid drug interactions by telling your doctor all of the other medications or herbal supplements you take before starting Nexium.
            • Less risk of drug interactions with Pantoprazole than with other proton pump inhibitors.
            • Avoid drug interactions by telling your doctor all of the other medications or herbal supplements you take before starting Pantoprazole.
            Food
            NexiumPantoprazole
            • Take 1 hour before a meal.
            • Take with or without food.
            Upsides and benefits
            NexiumPantoprazole
            • Most people can take Nexium without any noticeable day-to-day side effects.
            • Nexium lasts longer than other types of antacids (like Zantac, Pepcid, or Tums), and you only need to take it once or twice a day.
            • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
            • In studies it was better than a placebo (sugar pill) and as good as other proton pump inhibitors at treating heartburn.
            • Available as both a generic and over-the-counter option, so it's pretty affordable.
            • Most people can take Pantoprazole without any noticeable day-to-day side effects.
            • Pantoprazole lasts longer than other types of antacids (like Zantac, Pepcid, or Tums), and you only need to take it once or twice a day.
            • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
            • In studies it was better than a placebo (sugar pill) and as good as other proton pump inhibitors at treating heartburn.
            • Available as both a generic and over-the-counter option, so it's pretty affordable.
            Downsides and risks
            NexiumPantoprazole
            • Can cause low levels of magnesium in the blood. You might need to take a magnesium supplement if you use Nexium long-term.
            • Can be expensive—especially the purple brand-name pill. Other alternatives are usually cheaper than Nexium and work just as well.
            • Can interact with other drugs so be sure your doctor knows all the medicine you're taking before starting Nexium.
            • Doesn't start working as fast as some other antacids like Tums, Rolaids, or Maalox.
            • Like with other proton pump inhibitors, long-term use can cause weak or broken bones.
            • Can cause low levels of magnesium in the blood. You might need to take a magnesium supplement if you use Pantoprazole long-term.
            • Can be expensive. Other alternatives are usually cheaper than Pantoprazole.
            • Less risk of drug interactions with Pantoprazole than with other proton pump inhibitors.
            • Doesn't start working as fast as some other antacids like Tums, Rolaids, or Maalox.
            • Like with other proton pump inhibitors, long-term use can cause weak or broken bones.
            Tips from our pharmacists for people taking the medication
            NexiumPantoprazole
            • Take 1 hour before a meal.
            • Don't chew or crush capsules; swallow them whole.
            • If you have trouble swallowing you can carefully open the capsules and sprinkle the inside pellets onto applesauce. Swallow the applesauce without chewing or crushing the pellets.
            • When using Nexium long-term, take a calcium citrate with vitamin D supplement daily to prevent bone loss. Be sure it's calcium citrate because it works the best when using a proton pump inhibitor.
            • Get a blood test for your magnesium level once a year; you may need a magnesium supplement while using Nexium.
            • Avoid drug interactions by telling your doctor all of the other medications or herbal supplements you take before starting Nexium.
            • Take with or without food.
            • Swallow tablets whole; don't split, crush, or chew.
            • Take the oral suspension 30 minutes before a meal mixed only with applesauce or apple juice. Follow instructions carefully.
            • When using Pantoprazole long-term, take a calcium citrate with vitamin D supplement daily to prevent bone loss. Be sure it's calcium citrate because it works the best when using a proton pump inhibitor.
            • Get a blood test for your magnesium level once a year; you may need a magnesium supplement while using Pantoprazole.
            • Avoid drug interactions by telling your doctor all of the other medications or herbal supplements you take before starting Pantoprazole.
            Learn more
            More about NexiumSide effectsReviews & ratingsAlternativesFDA package insert
            Have you used Nexium (Esomeprazole)?
            Worth itNot sureNot worth it
            More about PantoprazoleSide effectsReviews & ratingsAlternativesFDA package insert
            Have you used Protonix (Pantoprazole)?
            Worth itNot sureNot worth it