Compare Nexium vs. Prevacid

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Nexium
(esomeprazole)

Prevacid
(lansoprazole)

Treats heartburn and stomach ulcers. Nexium (esomeprazole) gives you long-lasting heartburn relief but has some risks if used long term.Treats heartburn and stomach ulcers. Prevacid (lansoprazole) is an effective and inexpensive acid reducer commonly used to provide heartburn relief and help heal ulcers.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.45Nexium
Reviews for Nexium
75%
of people (All ages) say Nexium is worth it
59%
say it works well
11%
say it's a big hassle
1239 reviews
Have you used Nexium (esomeprazole)?
Worth itNot sureNot worth it
Reviews for Prevacid
71%
+4% better vs. Nexium
71%
-12% worse vs. Nexium
19%
+8% better vs. Nexium
Have you used Prevacid (lansoprazole)?
Worth itNot sureNot worth it
Side effects
NexiumPrevacid

The Nexium FDA package insert doesn’t have numbers about how common side effects are.

More about Nexium side effects »
  • Diarrhea 2%
  • Abdominal pain 1%
More Prevacid side effects »
How it works
NexiumPrevacid
Nexium (esomeprazole) is a proton pump inhibitor (PPI). It treats heartburn and heals ulcers by lowering the amount of acid in your stomach.Prevacid (lansoprazole) is a proton pump inhibitor (PPI). It lowers the amount of acid in your stomach by blocking the final step of stomach acid production.
Type of medication
NexiumPrevacid
Over-the-counterPrescription or OTC
Available as
NexiumPrevacid
  • Pill
  • Injection
  • Packet
  • Extended release
  • Dissolving tablet extended release
  • Liquid
Used for
NexiumPrevacid
  • GERD
  • H Pylori Bacterial Infection
Risk factors for serious side effects
NexiumPrevacid
  • Being treated at a hospital
  • High dose Nexium (esomeprazole)
  • Long-term treatment with Nexium (esomeprazole)
  • Low bone mineral density
  • Aged 65 years or older
Detailed Nexium (esomeprazole) risks & warnings »
  • High dose Prevacid (lansoprazole)
  • Long-term treatment with Prevacid (lansoprazole)
  • Low bone mineral density
  • Older age
Detailed Prevacid (lansoprazole) risks & warnings »
Pregnancy
Price
NexiumPrevacid
No price related info.
  • Prevacid (lansoprazole) is available over-the-counter and as inexpensive, generic options.
Interactions
NexiumPrevacid
  • Since some prescription drugs can interact with Nexium (esomeprazole), talk to your doctor about all the medicines that you're taking.
  • Some prescription drugs can interact with Prevacid (lansoprazole), so talk to your doctor or pharmacist about the medicines you are taking.
Kidneys and liver
NexiumPrevacid
  • Nexium (esomeprazole) can cause acute kidney damage that can occur at any time during treatment. If you notice blood in the urine, changes in urine output, swelling of the body, weight gain, fever, or confusion, stop taking Nexium (esomeprazole) and speak to your doctor immediately.
  • Prevacid (lansoprazole) can cause acute kidney damage that can occur at any time during treatment. Stop taking Prevacid (lansoprazole) and speak to your doctor immediately if you notice blood in the urine, changes in urine output, swelling of the body, weight gain, fever, or confusion.
Upsides and benefits
NexiumPrevacid
  • Most people can take Nexium (esomeprazole) without any noticeable day-to-day side effects.
  • Nexium (esomeprazole) lasts longer than other types of antacids (like Zantac, Pepcid, or Tums), and you only need to take it once a day.
  • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need quicker relief.
  • Nexium (esomeprazole) is inexpensive, with over-the-counter and generic options.
  • Coupons are available for the brand name - speak to your doctor or pharmacist.
  • The packet form is a good option if you have trouble swallowing pills.They can be mixed with water for easier swallowing.
  • Most people can take Prevacid (lansoprazole) without any noticeable day-to-day side effects.
  • Comes in a dissolving tablet to be placed on the tongue if you cannot or do not like to swallow pills.
  • Prevacid (lansoprazole) lasts longer than other types of antacids (like Zantac, Pepcid, or Tums), and you only need to take it once a day.
  • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
  • Prevacid (lansoprazole) is available over-the-counter and as inexpensive, generic options.
Downsides and risks
NexiumPrevacid
  • Doesn't start working right away like antacids (Tums, Rolaids, or Maalox).
  • It can take several days or weeks to start feeling benefits.
  • May not be the best choice for patients 65 years of age and older due to risk of bone fractures and severe diarrhea.
  • Doesn't start working right away like some other acid reducers (Tums, Rolaids, or Maalox).
  • May not be the best choice for patients 65 years of age and older due to risk of bone fractures and C. diff infection (bacterial).
  • Is used if you have frequent heartburns that occur more than 2 days per week. Speak to your doctor or pharmacist if you only have occasional heartburn.
Tips from our pharmacists for people taking the medication
NexiumPrevacid
  • Take Nexium (esomeprazole) with a full glass of water 1 hour before eating.
  • Starts working in as little as an hour.
  • It can take 1 to 4 days to take full effect.
  • Since some prescription drugs can interact with Nexium (esomeprazole), talk to your doctor about all the medicines that you're taking.
  • Do not take Nexium (esomeprazole) for more than 14 days, unless directed by your doctor. Speak to your doctor if your symptoms don't go away after 2 weeks.
  • Nexium (esomeprazole) capsules can be opened and sprinkled on 1 tablespoon of applesauce, cottage cheese, or yogurt. Swallow immediately after.
  • Take Prevacid (lansoprazole) with a full glass of water before eating.
  • Starts working in 1 to 3 hours. It can take 1 to 4 days to take full effect.
  • Some prescription drugs can interact with Prevacid (lansoprazole), so talk to your doctor or pharmacist about the medicines you are taking.
  • Do not take for more than 14 days, unless directed by your doctor. Speak to your doctor if your symptoms don't go away after 2 weeks.
  • Prevacid (lansoprazole) capsules can be opened and sprinkled on 1 tablespoon of applesauce, cottage cheese, or yogurt. Swallow immediately after. The dissolving tablets shouldn't be swallowed, broken, or chewed.
Learn more
More about NexiumSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Nexium (esomeprazole)?
Worth itNot sureNot worth it
More about PrevacidSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Prevacid (lansoprazole)?
Worth itNot sureNot worth it