Compare Niaspan vs. Lopid

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Niaspan (Niacin)

Prescription only

Lopid (Gemfibrozil)

Prescription only
Lowers cholesterol.

Niaspan (Niacin) lowers triglycerides, but isn't as good as statins for improving cholesterol levels.

4.2/ 7 average rating with 380 reviewsforNiaspan
Lowers triglyceride levels.

Lopid (Gemfibrozil) is a generically available medication that can lower triglyceride levels by up to 50%.

  • Lowers "bad" cholesterol (LDL) and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
  • Good for lowering triglycerides (fats).
  • Considered as a first choice medication for lowering triglyceride levels in the blood. Studies have shown it can reduce triglycerides by up to 50%.
  • Available as a generic.
  • Can be used with other medications, such as fish oil, to lower bad cholesterol and increase good cholesterol.
  • By itself, Niaspan (Niacin) isn't as effective as statins for improving cholesterol levels.
  • It can cause flushing and stomach pain or discomfort.
  • You need to take it before bedtime with a low-fat snack.
  • If you miss doses often, you may need to re-start taking the medicine more regularly at a lower dose.
  • While Lopid (Gemfibrozil) has been shown to lower triglycerides, it has not been shown by itself to reduce the number of deaths caused by high cholesterol.
  • Can't be used with statins to lower cholesterol because of the risk of muscle and kidney damage.
Used for
Dosage forms
  • Pill
  • Extended release
  • Pill
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Side effects
6possible side effects
  • Flushing
  • Itching
  • Diarrhea
  • Nausea
  • Rash
  • Cough increased
See more detailed side effects
The Lopid (Gemfibrozil) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Muscle pain

    Taking Niaspan (Niacin) with statins

  • Liver damage

    Heavy alcohol use

    ...and 1 more risk factors

  • High blood sugar


  • Low platelets

    Taking Niaspan (Niacin) with anticoagulants

  • Gout


See more detailed risks and warnings
  • Muscle pain

    Taking Lopid (Gemfibrozil) with statins

  • Liver damage

    Past history of liver disease

  • Increased bleeding risk

    Taking Lopid (Gemfibrozil) with anticoagulants

See more detailed risks and warnings