Compare Niaspan vs. Trilipix

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Niaspan
(Niacin)

Trilipix
(Fenofibric Acid)

Lowers cholesterol. niacin is good for lowering triglycerides (fats), but it's not as good as statins for improving cholesterol.Lowers cholesterol. Trilipix is good for lowering triglycerides (fats), but it's not as good as statins for improving cholesterol and cardiovascular disease risk.
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Reviews & ratings
Button Group. All currently active
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4.226315789473684Niaspan
Reviews for Niaspan (Niacin)
43%
of people say Niaspan (Niacin) is worth it
31%
say it works well
19%
say it's a big hassle
Reviews for Trilipix (Fenofibric Acid)
49%
+6% vs. Niaspan (Niacin)
22%
9% vs. Niaspan (Niacin)
25%
6% vs. Niaspan (Niacin)
Side effects
NiaspanTrilipix
  • Flushing 50%
  • Itching 6%
  • Vomiting 5%
  • Nausea 4%
  • Cough increased 2%
  • Diarrhea 1%
More Niaspan side effects »
  • Abnormal liver tests 7%
  • Increased creatine phosphokinase 2%
  • Abdominal pain 1%
  • Inflammation inside the nose 1%
  • Decreased liver function 1%
More Trilipix side effects »
How it works
NiaspanTrilipix
niacin is a cholesterol-lowering medicine. Researchers don't know exactly how it works, but it seems to lower the amount of "bad" cholesterol (LDL) made by the liver. It may also help your body process cholesterol.Trilipix is a cholesterol-lowering medicine. It removes triglycerides from your body and makes it easier to process "bad" cholesterol (LDL). This also increases "good" cholesterol (HDL).
Type of medication
NiaspanTrilipix
Cholesterol-lowering
Nicotinic acid
Prescription only
Cholesterol-lowering
Fibric acid
Prescription only
Available as
NiaspanTrilipix
  • Pill
  • Extended release
  • Pill
  • Extended release
Used for (click to learn more)
NiaspanTrilipix
Risk factors for serious side effects
NiaspanTrilipix
  • Taking Niaspan (Niacin) with statins
  • Heavy alcohol use
  • Past history of liver disease
  • Diabetes
  • Taking Niaspan (Niacin) with anticoagulants
Detailed Niaspan (Niacin) risks & warnings »
  • Taking Trilipix (Fenofibric Acid) with statins
  • Past history of liver disease
    • Taking Trilipix (Fenofibric Acid) with anticoagulants
              Detailed Trilipix (Fenofibric Acid) risks & warnings »
              Pregnancy category
              NiaspanTrilipix
              CFDA pregnancy category (Weigh risks vs. benefits)

              Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

              See the FDA package insert
              CFDA pregnancy category (Weigh risks vs. benefits)

              Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

              See the FDA package insert
              Alcohol
              • Avoid alcohol, spicy foods, and hot beverages right before you take this medicine.
              • People who take Niaspan (Niacin) have reported liver damage, especially if taken with statins or if you drink large amounts of alcohol. This has been rare. Talk to your doctor if you've ever had liver disease as they may discuss alternatives, or they may monitor your liver with blood tests.
              No specific alcohol-related info.
              Food
              • You have to take it before bedtime with a low-fat snack.
              • Take it at bedtime with a low-fat snack.
              • Avoid alcohol, spicy foods, and hot beverages right before you take this medicine.
              No specific food-related info.
              Kidneys and liver
              • People on Niaspan (Niacin) while taking statins have reported muscle pain which may lead to muscle and kidney damage. This has been very rare. Talk to your doctor if you develop sudden muscle pain or weakness or fever and you don't know why.
              • People on Trilipix (Fenofibric Acid) while taking statins have reported muscle pain which may lead to muscle and kidney damage. This has been very rare. Talk to your doctor if you develop sudden muscle pain or weakness or fever and you don't know why.
              Sex
              No specific sex-related info.No specific sex-related info.
              Sleep
              No specific sleep-related info.No specific sleep-related info.
              Weight
              No specific weight-related info.No specific weight-related info.
              Upsides and benefits
              NiaspanTrilipix
              • Lowers "bad" cholesterol (LDL) and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
              • Lowers the risk of a second heart attack.
              • Good for lowering triglycerides (fats).
              • Lowers "bad" cholesterol (LDL) and triglycerides (fats) and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
              • Good medicine for lowering triglycerides.
              Downsides and risks
              NiaspanTrilipix
              • By itself, niacin is not as effective as statins for improving cholesterol.
              • Can cause flushing and stomach pain or discomfort.
              • You have to take it before bedtime with a low-fat snack.
              • If you don't take it regularly, you might have to re-start the medicine at a lower dose.
              • In clinical studies, Trilipix hasn't lowered cholesterol or the risk of heart attack and stroke better than statins.
              • Different forms and strengths of this medication can't be substituted for each other.
              Tips from our pharmacists for people taking the medication
              NiaspanTrilipix
              • Take it at bedtime with a low-fat snack.
              • Avoid alcohol, spicy foods, and hot beverages right before you take this medicine.
              • Can cause flushing.
              • Call your doctor if you develop muscle pain.
              • Don't stop taking this medicine suddenly.
              • Can be used with other medications to help lower cholesterol.
              • Lowers triglycerides.
              • Can raise your chance of getting colds and flu.
              • Call your doctor if you develop muscle or abdominal pain.
              • Also taking Welchol or Questran? Take this medicine at least 2 hours before or 4 hours after.
              Learn more
              More about NiaspanSide effectsReviews & ratingsAlternativesFDA package insert
              More about TrilipixSide effectsReviews & ratingsAlternativesFDA package insert