Compare Niaspan vs. Trilipix

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Niaspan
(niacin)

Trilipix
(fenofibric acid)

Lowers cholesterol. Niaspan (Niacin) lowers triglycerides, but isn't as good as statins for improving cholesterol levels.Lowers cholesterol. Trilipix is good for lowering triglycerides (fats), but it's not as good as statins for improving cholesterol and cardiovascular disease risk.
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Prices and coupon for 30 (500mg) tablets of niacin
Coupons for
Prices and coupon for 30 (105mg) tablets of fenofibric acid
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.23Niaspan
Reviews for Niaspan (niacin)
43%
of people (All ages) say Niaspan (niacin) is worth it
31%
say it works well
19%
say it's a big hassle
380 reviews
Have you used Niaspan (niacin)?
Worth itNot sureNot worth it
Reviews for Trilipix (fenofibric acid)
50%
+7% better vs. Niaspan (niacin)
22%
-9% worse vs. Niaspan (niacin)
25%
-6% worse vs. Niaspan (niacin)
Have you used Trilipix (fenofibric acid)?
Worth itNot sureNot worth it
Side effects
NiaspanTrilipix
  • Flushing 49%
  • Itching 6%
  • Rash 5%
More Niaspan side effects »
  • Headache 13%
  • Back pain 6%
  • Pain in extremity 5%
  • Ear, nose, or throat infection 5%
  • Nausea 4%
  • Common cold 4%
  • Diarrhea 4%
  • Joint pain 4%
  • Pain 4%
  • Dizziness 4%
More Trilipix side effects »
How it works
NiaspanTrilipix
Niaspan (Niacin) is a cholesterol-lowering medicine. Researchers don't know exactly how it works, but it seems to lower the amount of "bad" cholesterol (LDL) made by the liver.Trilipix is a cholesterol-lowering medicine. It removes triglycerides from your body and makes it easier to process "bad" cholesterol (LDL). This also increases "good" cholesterol (HDL).
Type of medication
NiaspanTrilipix
Prescription only
Prescription only
Available as
NiaspanTrilipix
  • Pill
  • Extended release
  • Pill
  • Extended release
Used for
NiaspanTrilipix
Risk factors for serious side effects
NiaspanTrilipix
  • Taking Niaspan (Niacin) with statins
  • Heavy alcohol use
  • Past history of liver disease
  • Diabetes
  • Taking Niaspan (Niacin) with anticoagulants
  • Gout
Detailed Niaspan (niacin) risks & warnings »
  • Taking Trilipix (Fenofibric Acid) with statins
  • Past history of liver disease
    • Taking Trilipix (Fenofibric Acid) with anticoagulants
              Detailed Trilipix (fenofibric acid) risks & warnings »
              Pregnancy

              Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

              Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

              Interactions
              NiaspanTrilipix
              • Niaspan (Niacin) can interact with blood thinners and make you more likely to bleed. Your doctor may have you do regular blood tests and change your medication doses.
              No interactions related info.
              Alcohol
              NiaspanTrilipix
              • Don't have alcohol, spicy foods, or hot beverages right before you take this medicine.
              No alcohol related info.
              Food
              NiaspanTrilipix
              • You need to take it before bedtime with a low-fat snack.
              • Don't have alcohol, spicy foods, or hot beverages right before you take this medicine.
              • Niaspan (Niacin) can interact with blood thinners and make you more likely to bleed. Your doctor may have you do regular blood tests and change your medication doses.
              No food related info.
              Kidneys and liver
              NiaspanTrilipix
              No kidneys and liver related info.
              • Reports of liver damage have been reported in people who take Trilipix (Fenofibric Acid), especially in people with a history of liver disease. Your doctor may monitor your liver with blood tests on a regular basis.
              Pain
              NiaspanTrilipix
              • It can cause flushing and stomach pain or discomfort.
              No pain related info.
              Upsides and benefits
              NiaspanTrilipix
              • Lowers "bad" cholesterol (LDL) and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
              • Good for lowering triglycerides (fats).
              • Lowers "bad" cholesterol (LDL) and triglycerides (fats) and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
              • Good medicine for lowering triglycerides.
              Downsides and risks
              NiaspanTrilipix
              • By itself, Niaspan (Niacin) isn't as effective as statins for improving cholesterol levels.
              • It can cause flushing and stomach pain or discomfort.
              • You need to take it before bedtime with a low-fat snack.
              • If you miss doses often, you may need to re-start taking the medicine more regularly at a lower dose.
              • In clinical studies, Trilipix hasn't lowered cholesterol or the risk of heart attack and stroke better than statins.
              • Different forms and strengths of this medication can't be substituted for each other.
              Tips from our pharmacists for people taking the medication
              NiaspanTrilipix
              • Take Niaspan (Niacin) at bedtime with a low-fat snack.
              • Don't have alcohol, spicy foods, or hot beverages right before you take this medicine.
              • Can cause make your skin feel hot and change color. Your doctor may tell you to take an aspirin 30 minutes before you take Niaspan (Niacin) to reduce the flushing.
              • Call your doctor if you feel unexplained muscle pain.
              • Niaspan (Niacin) works differently from other medicines you can buy over-the-counter. Don't switch it with other medicines unless your doctor agrees.
              • Can be used with other medications to help lower cholesterol.
              • Lowers triglycerides.
              • Can raise your chance of getting colds and flu.
              • Call your doctor if you develop muscle or abdominal pain.
              • Also taking Welchol or Questran? Take this medicine at least 2 hours before or 4 hours after.
              Learn more
              More about NiaspanSide effectsReviews & ratingsAlternativesFDA package insert
              Have you used Niaspan (niacin)?
              Worth itNot sureNot worth it
              More about TrilipixSide effectsReviews & ratingsAlternativesFDA package insert
              Have you used Trilipix (fenofibric acid)?
              Worth itNot sureNot worth it