Compare Niaspan vs. Trilipix

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Niaspan
(Niacin)

Trilipix
(Fenofibric Acid)

Lowers cholesterol. niacin is good for lowering triglycerides (fats), but it's not as good as statins for improving cholesterol.Lowers cholesterol. Trilipix is good for lowering triglycerides (fats), but it's not as good as statins for improving cholesterol and cardiovascular disease risk.
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.23Niaspan
Reviews for Niaspan (Niacin)
43%
of people (All ages) say Niaspan (Niacin) is worth it
31%
say it works well
19%
say it's a big hassle
380 reviews
Have you used Niaspan (Niacin)?
Worth itNot sureNot worth it
Reviews for Trilipix (Fenofibric Acid)
50%
+7% vs. Niaspan (Niacin)
22%
9% vs. Niaspan (Niacin)
25%
6% vs. Niaspan (Niacin)
Have you used Trilipix (Fenofibric Acid)?
Worth itNot sureNot worth it
Side effects
NiaspanTrilipix
  • Flushing 50%
  • Itching 6%
  • Vomiting 5%
  • Nausea 4%
  • Cough increased 2%
  • Diarrhea 1%
More Niaspan side effects »
  • Abnormal liver tests 7%
  • Increased creatine phosphokinase 2%
  • Abdominal pain 1%
  • Inflammation inside the nose 1%
More Trilipix side effects »
How it works
NiaspanTrilipix
niacin is a cholesterol-lowering medicine. Researchers don't know exactly how it works, but it seems to lower the amount of "bad" cholesterol (LDL) made by the liver. It may also help your body process cholesterol.Trilipix is a cholesterol-lowering medicine. It removes triglycerides from your body and makes it easier to process "bad" cholesterol (LDL). This also increases "good" cholesterol (HDL).
Type of medication
NiaspanTrilipix
Cholesterol-lowering
Nicotinic acid
Prescription only
Cholesterol-lowering
Fibric acid
Prescription only
Available as
NiaspanTrilipix
  • Pill
  • Extended release
  • Pill
  • Extended release
Used for (click to learn more)
NiaspanTrilipix
Risk factors for serious side effects
NiaspanTrilipix
  • Taking Niaspan (Niacin) with statins
  • Heavy alcohol use
  • Past history of liver disease
  • Diabetes
  • Taking Niaspan (Niacin) with anticoagulants
Detailed risks & warnings »
  • Taking Trilipix (Fenofibric Acid) with statins
  • Past history of liver disease
  • Taking Trilipix (Fenofibric Acid) with anticoagulants
Detailed risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Alcohol
NiaspanTrilipix
  • Avoid alcohol, spicy foods, and hot beverages right before you take this medicine.
No alcohol related info.
Food
NiaspanTrilipix
  • You have to take it before bedtime with a low-fat snack.
  • Take it at bedtime with a low-fat snack.
  • Avoid alcohol, spicy foods, and hot beverages right before you take this medicine.
No food related info.
Kidneys and liver
NiaspanTrilipix
No kidneys and liver related info.
  • Reports of liver damage have been reported in people who take Trilipix (Fenofibric Acid), especially in people with a history of liver disease. Your doctor may monitor your liver with blood tests on a regular basis.
Pain
NiaspanTrilipix
  • Can cause flushing and stomach pain or discomfort.
No pain related info.
Upsides and benefits
NiaspanTrilipix
  • Lowers "bad" cholesterol (LDL) and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
  • Lowers the risk of a second heart attack.
  • Good for lowering triglycerides (fats).
  • Lowers "bad" cholesterol (LDL) and triglycerides (fats) and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
  • Good medicine for lowering triglycerides.
Downsides and risks
NiaspanTrilipix
  • By itself, niacin is not as effective as statins for improving cholesterol.
  • Can cause flushing and stomach pain or discomfort.
  • You have to take it before bedtime with a low-fat snack.
  • If you don't take it regularly, you might have to re-start the medicine at a lower dose.
  • In clinical studies, Trilipix hasn't lowered cholesterol or the risk of heart attack and stroke better than statins.
  • Different forms and strengths of this medication can't be substituted for each other.
Tips from our pharmacists for people taking the medication
NiaspanTrilipix
  • Take it at bedtime with a low-fat snack.
  • Avoid alcohol, spicy foods, and hot beverages right before you take this medicine.
  • Can cause flushing.
  • Call your doctor if you develop muscle pain.
  • Don't stop taking this medicine suddenly.
  • Can be used with other medications to help lower cholesterol.
  • Lowers triglycerides.
  • Can raise your chance of getting colds and flu.
  • Call your doctor if you develop muscle or abdominal pain.
  • Also taking Welchol or Questran? Take this medicine at least 2 hours before or 4 hours after.
Learn more
More about NiaspanSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Niaspan (Niacin)?
Worth itNot sureNot worth it
More about TrilipixSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Trilipix (Fenofibric Acid)?
Worth itNot sureNot worth it