Compare Niaspan vs. Vytorin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Niaspan
(niacin)

Vytorin
(ezetimibe / simvastatin)

Lowers cholesterol. Niaspan (Niacin) lowers triglycerides, but isn't as good as statins for improving cholesterol levels.Lowers cholesterol. Vytorin is expensive and is no more effective than simvastatin by itself.
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Coupons for Niaspan
Best available price for 30 (500mg) tablets of niacin
Coupons for Vytorin
Best available price for 30 (10mg/40mg) tablets of ezetimibe / simvastatin
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.23Niaspan
Reviews for Niaspan (niacin)
43%
of people (All ages) say Niaspan (niacin) is worth it
31%
say it works well
19%
say it's a big hassle
380 reviews
Have you used Niaspan (niacin)?
Worth itNot sureNot worth it
Reviews for Vytorin (ezetimibe / simvastatin)
53%
+10% better vs. Niaspan (niacin)
36%
+5% better vs. Niaspan (niacin)
19%
Same vs. Niaspan (niacin)
Have you used Vytorin (ezetimibe / simvastatin)?
Worth itNot sureNot worth it
Side effects
NiaspanVytorin
  • Flushing 49%
  • Itching 6%
  • Rash 5%
More Niaspan side effects »
  • Headache 1%
  • Any side effect 3%
  • Muscle pain 4%
  • Ear, nose, or throat infection 4%
  • Increased alt 4%
  • Diarrhea 3%
  • Flu 1%
  • Pain in extremity 1%
  • Unexplained muscle pain or weakness 1%
More Vytorin side effects »
How it works
NiaspanVytorin
Niaspan (Niacin) is a cholesterol-lowering medicine. Researchers don't know exactly how it works, but it seems to lower the amount of "bad" cholesterol (LDL) made by the liver.Vytorin is a combination cholesterol-lowering medicine. Simvastatin prevents your body from making "bad" cholesterol (LDL) while raising "good" cholesterol (HDL). Ezetimibe prevents cholesterol absorption in your intestines.
Type of medication
NiaspanVytorin
Prescription only
Prescription only
Available as
NiaspanVytorin
  • Pill
  • Extended release
  • Pill
Used for
NiaspanVytorin
Risk factors for serious side effects
NiaspanVytorin
  • Taking Niaspan (Niacin) with statins
  • Heavy alcohol use
  • Past history of liver disease
  • Diabetes
  • Taking Niaspan (Niacin) with anticoagulants
Detailed Niaspan (niacin) risks & warnings »
  • Asian patients taking high-dose niacin
  • Past history of liver disease
  • heavy alcohol use
  • Diabetes
  • Pregnancy
Detailed Vytorin (ezetimibe / simvastatin) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

Interactions
NiaspanVytorin
  • Niaspan (Niacin) can interact with blood thinners and make you more likely to bleed. Your doctor may have you do regular blood tests and change your medication doses.
No interactions related info.
Alcohol
NiaspanVytorin
  • Don't have alcohol, spicy foods, or hot beverages right before you take this medicine.
No alcohol related info.
Food
NiaspanVytorin
  • You need to take it before bedtime with a low-fat snack.
  • Don't have alcohol, spicy foods, or hot beverages right before you take this medicine.
  • Niaspan (Niacin) can interact with blood thinners and make you more likely to bleed. Your doctor may have you do regular blood tests and change your medication doses.
No food related info.
Kidneys and liver
NiaspanVytorin
No kidneys and liver related info.
  • People on Vytorin (Ezetimibe / Simvastatin) have reported muscle pain which may lead to muscle breakdown and kidney damage, especially in people of Asian ancestry who are also taking niacin. This has been very rare. Talk to your doctor if you suddenly develop muscle pain and a fever and you don't know why.
Pain
NiaspanVytorin
  • It can cause flushing and stomach pain or discomfort.
No pain related info.
Upsides and benefits
NiaspanVytorin
  • Lowers "bad" cholesterol (LDL) and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
  • Good for lowering triglycerides (fats).
  • A 2-in-1 cholesterol-lowering combination medicine.
  • Lowers "bad" cholesterol (LDL) and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
Downsides and risks
NiaspanVytorin
  • By itself, Niaspan (Niacin) isn't as effective as statins for improving cholesterol levels.
  • It can cause flushing and stomach pain or discomfort.
  • You need to take it before bedtime with a low-fat snack.
  • If you miss doses often, you may need to re-start taking the medicine more regularly at a lower dose.
  • In clinical studies, simvastatin/ezetimibe hasn't controlled cholesterol better than simvastatin alone.
  • There's no generic available, so it can be expensive.
Tips from our pharmacists for people taking the medication
NiaspanVytorin
  • Take Niaspan (Niacin) at bedtime with a low-fat snack.
  • Don't have alcohol, spicy foods, or hot beverages right before you take this medicine.
  • Can cause make your skin feel hot and change color. Your doctor may tell you to take an aspirin 30 minutes before you take Niaspan (Niacin) to reduce the flushing.
  • Call your doctor if you feel unexplained muscle pain.
  • Niaspan (Niacin) works differently from other medicines you can buy over-the-counter. Don't switch it with other medicines unless your doctor agrees.
  • Take it in the evening.
  • Avoid grapefruit and grapefruit juice while taking this medicine.
  • Can cause headaches or diarrhea.
  • Call your doctor if you develop muscle pain.
  • Also taking Welchol or Questran? Take this medicine at least 2 hours before or 4 hours after.
Learn more
More about NiaspanSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Niaspan (niacin)?
Worth itNot sureNot worth it
More about VytorinSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Vytorin (ezetimibe / simvastatin)?
Worth itNot sureNot worth it