Compare Nifedipine vs. hydrochlorothiazide

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Lowers blood pressure and controls heart rate.

Nifedipine works well to lower blood pressure and prevent chest pain, but you have to be okay with avoiding grapefruit. You can't miss doses, and you might get persistent swelling.

2.8/ 5 average rating with 26 reviewsforNifedipine
Removes water from the body, which lowers blood pressure.

Microzide (hydrochlorothiazide (HCTZ)) is a well-tolerated water pill that's often the first-choice treatment for mild high blood pressure.

3.3/ 5 average rating with 139 reviewsforhydrochlorothiazide
Upsides
  • A first-choice blood pressure treatment for many people.
  • Calcium channel blockers work especially well for African Americans to lower blood pressure.
  • You can take it alone or with other medicines to help lower blood pressure.
  • Lowers the risk of heart attack and stroke.
  • Prevents heart-related chest pain (angina) if you take it regularly.
  • Treats certain abnormal heart rhythms.
  • Does a good job getting rid of extra fluids in your body by making you urinate more.
  • A first-choice blood pressure treatment. Works especially well for people of African descent.
  • Lowers the risk of heart attack and stroke.
  • Good option if you have high blood pressure and heart failure.
  • Most people have very few side effects from Microzide (hydrochlorothiazide (HCTZ)).
  • Can be good for patients with osteoporosis since it raises the body's level of calcium.
Downsides
  • Calcium channel blockers can cause swelling in your limbs. If this happens for you, it probably won't get better over time, so talk to your doctor about alternatives if it bothers you.
  • Women are more likely to have side effects (especially swelling) from Nifedipine than men.
  • You can't miss doses. Stopping Nifedipine suddenly can cause your blood pressure to go up suddenly, which raises the risk of heart attack and stroke.
  • Not a good medication for you if you love grapefruit. It can make Nifedipine have a stronger effect on your blood pressure.
  • Makes you urinate more often.
  • Microzide (hydrochlorothiazide (HCTZ)) doesn't work well in people with severe kidney problems.
  • It can increase the risk of gout attacks in people with poor kidney function or a history of gout.
  • People with a sulfa allergy may be allergic to Microzide (hydrochlorothiazide (HCTZ)).
Used for
Dosage forms
  • Pill
  • Extended release
  • Pill
Price
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Reviews
26 reviews so far
42%
saidit'sworth it
31%
saiditworked well
46%
saidit'sa big hassle

Have you used Procardia (Nifedipine)?

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139 reviews so far
47%
saidit'sworth it
31%
saiditworked well
16%
saidit'sa big hassle

Have you used Microzide (hydrochlorothiazide (HCTZ))?

Leave a review
Side effects
11possible side effects
  • Dizziness, lightheadedness, giddiness
    27%
  • Flushing
    25%
  • Headache
    23%
  • Weakness
    12%
  • Nausea, heartburn
    11%
  • Muscle cramps, tremor
    8%
  • Peripheral edema
    7%
  • Nervousness, mood changes
    7%
  • Palpitation
    7%
  • Dyspnea, cough, wheezing
    6%
  • Nasal congestion, sore throat
    6%
See more detailed side effects
The Microzide (hydrochlorothiazide (HCTZ)) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Intestinal blockage
    • Taking anti-inflammatories, acid reducers in the stomach, anticholinergics, laxatives, levothyroxine
    • History of intestinal surgery
  • Chest pain
    • Taking beta-blockers
    • Severe coronary artery disease.
  • Liver damage/jaundice
    • History of cirrhosis
  • Low blood pressure
  • Congestive heart failure
    • History of tight aortic stenosis
    • Taking beta-blockers
  • Heart attack or increased chest pain
    • Obstructive coronary artery disease
See more detailed risks and warnings
  • Dehydration and electrolyte imbalance
    • Current electrolyte imbalance
    • Lower kidney function
    • Dehydration
  • Severe allergic reactions
    • History of sulfa allergies
  • Gout
    • History of gout
    • Current kidney problems
  • Vision problems
    • History of sulfa or penicillin allergies
  • Higher blood sugars
    • Diabetes
See more detailed risks and warnings
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Disclaimer: We don't provide medical advice. If you think you might have a medical emergency, call your doctor or 911 immediately.