Compare Nifedipine vs. Hydrochlorothiazide

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Procardia
(Nifedipine)

Microzide
(Hydrochlorothiazide )

Lowers blood pressure and controls heart rate. Nifedipine works well to lower blood pressure and prevent chest pain, but you have to be okay with avoiding grapefruit. You can't miss doses, and you might get persistent swelling.Lowers blood pressure. Removes extra water from your body. Microzide (Hydrochlorothiazide (Hctz)) is a well-tolerated water pill that's often the first-choice treatment for mild high blood pressure.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
3.6Nifedipine
Reviews for Procardia (Nifedipine)
40%
of people say Procardia (Nifedipine) is worth it
28%
say it works well
48%
say it's a big hassle
Reviews for Microzide (Hydrochlorothiazide (Hctz))
47%
+7% vs. Procardia (Nifedipine)
31%
+3% vs. Procardia (Nifedipine)
15%
+33% vs. Procardia (Nifedipine)
Side effects
NifedipineHydrochlorothiazide
  • Leg or ankle swelling 19%
  • Flushing 17%
  • Dizziness, lightheadedness, giddiness 12%
  • Muscle cramps, tremor 5%
  • Nervousness, mood changes 3%
  • Headache 3%
  • Dyspnea, cough, wheezing 3%
  • Nausea, heartburn 3%
  • Heart pounding or racing sensation 2%
  • Dizziness 2%
More Nifedipine side effects »

The Hydrochlorothiazide FDA package insert doesn’t have numbers about how common side effects are.

More about Hydrochlorothiazide side effects »
How it works
NifedipineHydrochlorothiazide
Nifedipine is a calcium channel blocker. It lowers blood pressure by slowing your heart rate and relaxing your blood vessels. Your heart gets more oxygen and doesn't have to work as hard to pump, which can relieve chest pain.Microzide (Hydrochlorothiazide (Hctz)) is a thiazide diuretic (water pill). It works in the kidneys to make you urinate more, which removes extra water and certain electrolytes. This lowers blood pressure and swelling.
Type of medication
NifedipineHydrochlorothiazide
Antihypertensive
Calcium channel blocker
Prescription only
Antihypertensive
Diuretic
Prescription only
Available as
NifedipineHydrochlorothiazide
  • Pill
  • Extended release
  • Pill
Used for (click to learn more)
NifedipineHydrochlorothiazide
Risk factors for serious side effects
NifedipineHydrochlorothiazide
  • Taking anti-inflammatories, acid reducers in the stomach, anticholinergics, laxatives, levothyroxine
  • History of intestinal surgery
  • Taking beta-blockers
  • Severe coronary artery disease.
  • History of cirrhosis
    • History of tight aortic stenosis
    • Taking beta-blockers
    • Obstructive coronary artery disease
    Detailed Procardia (Nifedipine) risks & warnings »
    • Current electrolyte imbalance
    • History of sulfa allergies
    • History of gout
    • Current kidney problems
      Detailed Microzide (Hydrochlorothiazide (Hctz)) risks & warnings »
      Pregnancy category
      NifedipineHydrochlorothiazide
      CFDA pregnancy category (Weigh risks vs. benefits)

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      See the FDA package insert
      BFDA pregnancy category (Probably safe)

      Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

      See the FDA package insert
      Alcohol
      No specific alcohol-related info.No specific alcohol-related info.
      Food
      No specific food-related info.No specific food-related info.
      Kidneys and liver
      No specific kidneys and liver-related info.
      • Doesn't work well in people with severe kidney problems.
      • Requires routine blood tests to check kidney function.
      Sex
      No specific sex-related info.No specific sex-related info.
      Sleep
      No specific sleep-related info.No specific sleep-related info.
      Weight
      No specific weight-related info.No specific weight-related info.
      Upsides and benefits
      NifedipineHydrochlorothiazide
      • A first-choice blood pressure treatment for many people.
      • Calcium channel blockers work especially well for African Americans to lower blood pressure.
      • You can take it alone or with other medicines to help lower blood pressure.
      • Prevents heart-related chest pain (angina) if you take it regularly.
      • Treats certain abnormal heart rhythms.
      • Lowers the risk of heart attack and stroke.
      • Works well to get rid of extra fluids in your body through urination.
      • A first-choice blood pressure treatment for many people. Works especially well for African Americans.
      • Good option if you have both high blood pressure and heart failure.
      • Raises calcium levels in the body, so it can be good for people with osteoporosis to slow down bone loss and even help with new bone formation.
      • Most people have very few side effects.
      • Lowers the risk of heart attack and stroke.
      Downsides and risks
      NifedipineHydrochlorothiazide
      • Calcium channel blockers can cause swelling in your limbs. If this happens for you, it probably won't get better over time, so talk to your doctor about alternatives if it bothers you.
      • Women are more likely to have side effects (especially swelling) from Nifedipine than men.
      • You can't miss doses. Stopping Nifedipine suddenly can cause your blood pressure to go up suddenly, which raises the risk of heart attack and stroke.
      • Not a good medication for you if you love grapefruit. It can make Nifedipine have a stronger effect on your blood pressure.
      • Makes you urinate more often.
      • Doesn't work well in people with severe kidney problems.
      Tips from our pharmacists for people taking the medication
      NifedipineHydrochlorothiazide
      • Can cause dizziness or headaches in the first few days.
      • Can cause face flushing and ankle or foot swelling.
      • Avoid grapefruit while taking this medicine.
      • Your doctor might do routine blood tests to check your liver function.
      • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
      • Starts working in about 2 hours.
      • Makes you urinate more often, so avoid taking it at bedtime.
      • Can cause dizziness in the first few days.
      • Tell your doctor about any dizziness, fatigue, or muscle weakness that doesn't go away.
      • Requires routine blood tests to check kidney function.
      • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
      Learn more
      More about NifedipineSide effectsReviews & ratingsAlternativesFDA package insert
      More about HydrochlorothiazideSide effectsReviews & ratingsAlternativesFDA package insert