Compare Nifedipine vs. Lisinopril

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Procardia
(Nifedipine)

Zestril
(Lisinopril)

Lowers blood pressure and controls heart rate. Nifedipine works well to lower blood pressure and prevent chest pain, but you have to be okay with avoiding grapefruit. You can't miss doses, and you might get persistent swelling.Lowers blood pressure. Zestril (Lisinopril) is a good blood pressure-lowering medicine that protects kidney function.
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Reviews & ratings
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Have you used Procardia (Nifedipine)?
Worth itNot sureNot worth it
Reviews for Zestril (Lisinopril)
61%
+19% better vs. Procardia (Nifedipine)
51%
+20% better vs. Procardia (Nifedipine)
14%
+32% better vs. Procardia (Nifedipine)
687 reviews
Have you used Zestril (Lisinopril)?
Worth itNot sureNot worth it
Side effects
NifedipineLisinopril
  • Dizziness, lightheadedness, giddiness 12%
  • Flushing 17%
  • Headache 3%
  • Weakness 2%
  • Nausea, heartburn 3%
  • Muscle cramps, tremor 5%
  • Leg or ankle swelling 6%
  • Nervousness, mood changes 3%
  • Heart pounding or racing sensation 2%
  • Dyspnea, cough, wheezing 3%
More Nifedipine side effects »
  • Headache 4%
  • Dizziness 3%
  • Cough 3%
  • Diarrhea 1%
  • Fatigue 2%
  • Infection 2%
  • Low blood pressure 4%
  • Chest pain 2%
More Lisinopril side effects »
How it works
NifedipineLisinopril
Nifedipine is a calcium channel blocker. It lowers blood pressure by slowing your heart rate and relaxing your blood vessels. Your heart gets more oxygen and doesn't have to work as hard to pump, which can relieve chest pain.Zestril (Lisinopril) is an angiotensin converting enzyme (ACE) inhibitor. It blocks a chemical that tightens blood vessels. This makes blood vessels relax, which lowers blood pressure and allows more blood and oxygen to get to your heart and other organs.
Type of medication
NifedipineLisinopril
Prescription only
Prescription only
Available as
NifedipineLisinopril
  • Pill
  • Extended release
  • Pill
Used for
NifedipineLisinopril
Risk factors for serious side effects
NifedipineLisinopril
  • Taking anti-inflammatories, acid reducers in the stomach, anticholinergics, laxatives, levothyroxine
  • History of intestinal surgery
  • Taking beta-blockers
  • Severe coronary artery disease.
  • History of cirrhosis
    • History of tight aortic stenosis
    • Taking beta-blockers
    • Obstructive coronary artery disease
    Detailed Procardia (Nifedipine) risks & warnings »
    • Women of childbearing age
      • African descent
      • Current kidney problems
      • Medicine that increase potassium
      • Use of salt substitute
      Detailed Zestril (Lisinopril) risks & warnings »
      Pregnancy

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Kidneys and liver
      NifedipineLisinopril
      • Reports of liver damage have occurred while on this medication, especially if you have had cirrhosis. Your doctor will monitor your liver on a regular basis. Tell your doctor if you or your caregivers/family notice your skin or the whites of your eyes are becoming yellower, pain in your abdomen, or sudden confusion.
      • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
      • Requires routine blood tests to check kidney function.
      Upsides and benefits
      NifedipineLisinopril
      • A first-choice blood pressure treatment for many people.
      • Calcium channel blockers work especially well for African Americans to lower blood pressure.
      • You can take it alone or with other medicines to help lower blood pressure.
      • Lowers the risk of heart attack and stroke.
      • Prevents heart-related chest pain (angina) if you take it regularly.
      • Treats certain abnormal heart rhythms.
      • A first-choice blood pressure treatment for many people.
      • Lowers the risk of heart attack and stroke.
      • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
      • Recommended for anyone with heart failure since it lowers the risk of death and further damage to your heart.
      Downsides and risks
      NifedipineLisinopril
      • Calcium channel blockers can cause swelling in your limbs. If this happens for you, it probably won't get better over time, so talk to your doctor about alternatives if it bothers you.
      • Women are more likely to have side effects (especially swelling) from Nifedipine than men.
      • You can't miss doses. Stopping Nifedipine suddenly can cause your blood pressure to go up suddenly, which raises the risk of heart attack and stroke.
      • Not a good medication for you if you love grapefruit. It can make Nifedipine have a stronger effect on your blood pressure.
      • Up to 1 in 10 people can get a dry cough with this medicine. It ranges from a mild tickle in the throat to a persistent hacking cough.
      • Requires a yearly blood test to see how the medicine is affecting your body.
      • Not safe to use if you're pregnant.
      Tips from our pharmacists for people taking the medication
      NifedipineLisinopril
      • Can cause dizziness or headaches in the first few days.
      • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
      • Can cause face flushing and ankle or foot swelling.
      • Avoid grapefruit while taking this medicine.
      • Your doctor might do routine blood tests to check your liver function.
      • Can cause dizziness in the first few days.
      • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
      • Tell your doctor about any dizziness, fatigue, cough, or throat irritation that doesn't go away.
      • Requires routine blood tests to check kidney function.
      • Don't take it if you're pregnant.
      Learn more
      More about NifedipineSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Procardia (Nifedipine)?
      Worth itNot sureNot worth it
      More about LisinoprilSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Zestril (Lisinopril)?
      Worth itNot sureNot worth it