Compare Nifedipine vs. Lopressor

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Procardia
(Nifedipine)

Lopressor
(Metoprolol Tartrate)

Lowers blood pressure and controls heart rate. Nifedipine works well to lower blood pressure and prevent chest pain, but you have to be okay with avoiding grapefruit. You can't miss doses, and you might get persistent swelling.Lowers blood pressure and controls heart rate. Lopressor (Metoprolol Tartrate) is good for controlling chest pain and treating heart failure and heart attack. You have to take it with food, and you can't miss doses.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
3.6Nifedipine
Reviews for Procardia (Nifedipine)
40%
of people say Procardia (Nifedipine) is worth it
28%
say it works well
48%
say it's a big hassle
Reviews for Lopressor (Metoprolol Tartrate)
61%
+21% vs. Procardia (Nifedipine)
46%
+18% vs. Procardia (Nifedipine)
15%
+33% vs. Procardia (Nifedipine)
Side effects
NifedipineLopressor
  • Leg or ankle swelling 19%
  • Flushing 17%
  • Dizziness, lightheadedness, giddiness 12%
  • Muscle cramps, tremor 5%
  • Nervousness, mood changes 3%
  • Headache 3%
  • Dyspnea, cough, wheezing 3%
  • Nausea, heartburn 3%
  • Heart pounding or racing sensation 2%
  • Dizziness 2%
More Nifedipine side effects »
  • Abnormally slow heartbeat 9%
  • Low blood pressure 4%
  • First-degree heart block 3%
More Lopressor side effects »
How it works
NifedipineLopressor
Nifedipine is a calcium channel blocker. It lowers blood pressure by slowing your heart rate and relaxing your blood vessels. Your heart gets more oxygen and doesn't have to work as hard to pump, which can relieve chest pain.Lopressor (Metoprolol Tartrate) is a beta blocker. It lowers blood pressure by slowing heart rate, relaxing blood vessels, and lowering the body's fight-or-flight response.
Type of medication
NifedipineLopressor
Antihypertensive
Calcium channel blocker
Prescription only
Antihypertensive
Beta blocker
Prescription only
Available as
NifedipineLopressor
  • Pill
  • Extended release
  • Pill
Used for (click to learn more)
NifedipineLopressor
Risk factors for serious side effects
NifedipineLopressor
  • Taking anti-inflammatories, acid reducers in the stomach, anticholinergics, laxatives, levothyroxine
  • History of intestinal surgery
  • Taking beta-blockers
  • Severe coronary artery disease.
  • History of cirrhosis
    • History of tight aortic stenosis
    • Taking beta-blockers
    • Obstructive coronary artery disease
    Detailed Procardia (Nifedipine) risks & warnings »
    • Diabetes
      • Coronary artery disease
      • Heart failure
      • Major surgery requiring anesthesia
      • History of asthma
      Detailed Lopressor (Metoprolol Tartrate) risks & warnings »
      Pregnancy category
      NifedipineLopressor
      CFDA pregnancy category (Weigh risks vs. benefits)

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      See the FDA package insert
      CFDA pregnancy category (Weigh risks vs. benefits)

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      See the FDA package insert
      Alcohol
      No specific alcohol-related info.No specific alcohol-related info.
      Food
      No specific food-related info.
      • Metoprolol tartrate is the immediate release version of Toprol XL. You have to take Metoprolol tartrate with food for it to work best. (On the other hand, you can take Toprol XL any time.)
      • Take it with food.
      Kidneys and liver
      No specific kidneys and liver-related info.No specific kidneys and liver-related info.
      Sex
      No specific sex-related info.No specific sex-related info.
      Sleep
      No specific sleep-related info.No specific sleep-related info.
      Weight
      No specific weight-related info.No specific weight-related info.
      Upsides and benefits
      NifedipineLopressor
      • A first-choice blood pressure treatment for many people.
      • Calcium channel blockers work especially well for African Americans to lower blood pressure.
      • You can take it alone or with other medicines to help lower blood pressure.
      • Lowers the risk of heart attack and stroke.
      • Prevents heart-related chest pain (angina) if you take it regularly.
      • Treats certain abnormal heart rhythms.
      • A first-choice treatment to prevent chest pain (angina). Makes pain attacks less frequent and makes it easier to be active without having chest pain.
      • A first-choice treatment for heart failure. May prevent long-term heart damage.
      • A first-choice treatment for heart attack. Lowers the risk of death during and after a heart attack.
      Downsides and risks
      NifedipineLopressor
      • Calcium channel blockers can cause swelling in your limbs. If this happens for you, it probably won't get better over time, so talk to your doctor about alternatives if it bothers you.
      • Women are more likely to have side effects (especially swelling) from Nifedipine than men.
      • You can't miss doses. Stopping Nifedipine suddenly can cause your blood pressure to go up suddenly, which raises the risk of heart attack and stroke.
      • Not a good medication for you if you love grapefruit. It can make Nifedipine have a stronger effect on your blood pressure.
      • Metoprolol tartrate is the immediate release version of Toprol XL. You have to take Metoprolol tartrate with food for it to work best. (On the other hand, you can take Toprol XL any time.)
      • Taking a beta blocker might make you feel more tired or out of breath during exercise or normal daily routines. This gets better for most people, but for some might not go away.
      • Not a first-choice treatment for high blood pressure according to the latest guidelines, except if you have heart failure or heart disease. As a second choice, your doctor might add it to medicines you're already taking if your blood pressure is still too high.
      • Can hide symptoms of low blood sugar if you're diabetic.
      • You can't miss doses. Stopping Metoprolol tartrate suddenly can cause your blood pressure to go up suddenly, which raises the risk of heart attack and stroke.
      Tips from our pharmacists for people taking the medication
      NifedipineLopressor
      • Can cause dizziness or headaches in the first few days.
      • Can cause face flushing and ankle or foot swelling.
      • Avoid grapefruit while taking this medicine.
      • Your doctor might do routine blood tests to check your liver function.
      • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
      • Take it with food.
      • Can cause dizziness in the first few days.
      • Can cause fatigue and headache.
      • Can hide symptoms of low blood sugar. Be careful if you're diabetic.
      • Don't stop taking this medicine suddenly.
      • This is the immediate release version. It also comes as an extended release form: Toprol XL (metoprolol succinate).
      • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
      Learn more
      More about NifedipineSide effectsReviews & ratingsAlternativesFDA package insert
      More about LopressorSide effectsReviews & ratingsAlternativesFDA package insert